{"product_id":"prohealth-sirtuin-6-activator-60-capsules-ph664","title":"Sirtuin 6 Activator - 60 capsules","description":"\u003cdiv class=\"product-benefits-copy\"\u003e\n\u003cp\u003e\u003cstrong style=\"font-size: 1.1em;\"\u003eSirtuin 6 Activator: Inspired by the Blue Zones \u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eActivates sirtuin 6 (SIRT6)\u003csup\u003e1,4,6,7*\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003cli\u003eProvides “Blue Zone” bioactives*\u003csup\u003e5,6 \u003c\/sup\u003e\n\u003c\/li\u003e\n\u003cli\u003eSupports multiple longevity pathways*\u003csup\u003e5 \u003c\/sup\u003e\n\u003c\/li\u003e\n\u003cli\u003eNeutralizes free radicals*\u003csup\u003e5,12\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003cli\u003eSupports a healthy immune system \u0026amp; inflammatory response* \u003csup\u003e8,5,9-11\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cspan style=\"color: #0000ff;\"\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0507\/7588\/3936\/files\/PH664_-_COA_Qalitex_LOT_A24L017_2025-02-11.pdf?v=1743025431\" rel=\"noopener noreferrer\" style=\"color: #0000ff;\" target=\"_blank\"\u003eView Certificate of Analysis \u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eNot all fucoidan is created equal. After three years of extensive research and testing, we've finally sourced an authentic \u003cem\u003eFucus vesiculosus\u003c\/em\u003e—a special type of seaweed renowned for its powerful fucoidan content and abundant marine polyphenols. This premium seaweed extract sets a new benchmark in longevity science.* \u003csup\u003e2,5,8,13,21,22,25\u003c\/sup\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong style=\"font-size: 1.1em;\"\u003eWhat Makes Ours Better?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eFucoidan-Rich Seaweed:\u003c\/strong\u003e We deliver pure, concentrated seaweed—not synthetic compounds or low-quality extracts—packed with fucoidan, a potent SIRT6 activator.*\u003csup\u003e21,22\u003c\/sup\u003e \u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLongevity Boost:\u003c\/strong\u003e Each serving provides a full 400mg dose of fucoidan, the scientifically-backed compound for healthy aging.*\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFull Spectrum Support:\u003c\/strong\u003e Our formula blends whole-plant seaweed powder with high-potency extracts, offering a more complete range of bioactive compounds to amplify fucoidan’s anti-aging potential.*\u003csup\u003e12,15\u003c\/sup\u003e\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMaximized Bioactivity:\u003c\/strong\u003e Unlike many seaweed extracts that lose potency through harsh processing, our fucoidan is gently extracted using a specialized water-based method, preserving its full molecular structure for optimal effectiveness.*\u003csup\u003e5\u003c\/sup\u003e\u003cbr\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong style=\"font-size: 1.1em;\"\u003eWhy Choose ProHealth?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eDoctor-Formulated:\u003c\/strong\u003e Developed by our in-house science team in collaboration with leading wellness experts to address the root causes of aging.*\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTriple Lab Tested:\u003c\/strong\u003e Subjected to three rounds of independent third-party lab testing to ensure unmatched potency and purity.\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFull Transparency:\u003c\/strong\u003e In an industry full of misleading claims, we publish our third-party lab results—so you always know exactly what’s in every bottle.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eManufactured in the USA:\u003c\/strong\u003e Made in FDA-regulated, GMP-certified facilities, adhering to the highest quality and safety standards.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003e100-Day Risk-Free Guarantee:\u003c\/strong\u003e We’re confident you’ll love our product. If you’re not satisfied, contact our Santa Barbara, CA office for a full refund within 100 days—no hassle, no questions asked.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong style=\"font-size: 1.1em;\"\u003eNot all fucoidan is created equal. \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eFor centuries, Japan—home to one of the world’s longest-living populations—has relied on seaweed as a dietary staple, prized for its powerful antioxidants and cellular-protective compounds. Research consistently links regular seaweed consumption to enhanced health and longevity, reinforcing its vital role in healthy aging.*\u003csup\u003e15\u003c\/sup\u003e\u003c\/p\u003e\nBuilding on this tradition, \u003cstrong\u003eSirtuin 6 Activator\u003c\/strong\u003e delivers fucoidan, one of seaweed’s most potent bioactive compounds. Naturally found in the cell walls of brown seaweed, fucoidan is clinically recognized for its ability to activate SIRT6, a key enzyme that supports healthy aging at the cellular level.*\u003csup\u003e1\u003c\/sup\u003e\n\u003cp\u003eBy activating SIRT6, this fucoidan-rich formula goes beyond simple antioxidant support to revitalize cellular health at its core. Research shows that increased SIRT6 activity can aid in DNA repair, boost genomic stability, and support a healthy systemic inflammatory response—processes linked to longevity in Blue Zone populations.*\u003csup\u003e5,8,9,12,14,16\u003c\/sup\u003e\u003c\/p\u003e\nEmerging studies further suggest that higher SIRT6 activity correlates with longer lifespans in multiple animal species. Scientists are now exploring its potential for brain aging, heart health, and overall longevity, with human trials underway to further uncover its impact on healthy aging.*\u003csup\u003e20,26-28\u003c\/sup\u003e\n\u003cp\u003e\u003cstrong style=\"font-size: 1.1em;\"\u003e\u003cbr\u003eSirtuin 6 Activator: Inspired by the Blue Zones \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eAging is associated with cellular changes, including DNA damage, inflammation, and metabolic shifts, all of which have been studied in relation to SIRT6’s biological functions. Research suggests that SIRT6 plays a role in key cellular processes that support overall health.*\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eSupports DNA Repair\u003c\/strong\u003e – SIRT6 stabilizes the genome by repairing double-strand breaks and maintaining telomere integrity, reducing genetic instability, a major hallmark of aging.*\u003csup\u003e6\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eInfluences Metabolic Balance\u003c\/strong\u003e – SIRT6 shifts cells away from inefficient sugar metabolism and toward fat oxidation, mimicking the anti-aging effects of caloric restriction.*\u003csup\u003e17\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eClears Senescent Cells\u003c\/strong\u003e – Fucoidan acts as a potential senolytic, helping the body remove dysfunctional cells that drive aging.*\u003csup\u003e4,13,19\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eProtects Mitochondria\u003c\/strong\u003e – SIRT6 supports healthy cellular energy production, safeguarding from oxidative stress so cells can generate energy efficiently.*\u003csup\u003e5\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong style=\"font-size: 1.1em;\"\u003eNeutralizes Free Radicals* \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eOxidative stress occurs when free radicals accumulate and damage cells, proteins, and DNA—a primary driver of aging. ProHealth Sirtuin 6 Activator combats oxidative damage through multiple pathways:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eDirectly Scavenges Free Radicals\u003c\/strong\u003e – Fucoidan’s unique sulfated polysaccharide structure binds to and neutralizes reactive oxygen species (ROS) before they can harm cells.*\u003csup\u003e12\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eProvides Antioxidant Support\u003c\/strong\u003e – This formula combines fucoidan with polyphloroglucinols, marine polyphenols that strengthen cellular defenses against oxidative damage.*\u003csup\u003e5\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eEnhances Cellular Antioxidant Pathways\u003c\/strong\u003e – By enhancing glutathione and superoxide dismutase (SOD) levels, SIRT6 supports the body’s natural ability to maintain oxidative homeostasis.*\u003csup\u003e12\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong style=\"font-size: 1.1em;\"\u003eSupports a Healthy Immune System \u0026amp; Inflammatory Response* \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eHealthy immune system and inflammatory responses are essential for long-term health and longevity. Research suggests that fucoidan and SIRT6 may help support immune function and inflammation balance through multiple pathways:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eSupports Immune Cell Activity\u003c\/strong\u003e – Fucoidan supports the activity of macrophages, natural killer (NK) cells, and lymphocytes, helping to maintain a robust immune system and clear damaged cells.*\u003csup\u003e5,8,10\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHelps Maintain a Healthy Inflammatory Response\u003c\/strong\u003e – SIRT6 influences cytokine activity and inflammatory response mechanisms, helping to support healthy inflammation for optimal aging.* \u003csup\u003e5,8,9\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eEnhances Gut-Immune Function\u003c\/strong\u003e – Fucoidan supports a healthy gut microbiome, which is closely linked to immune and inflammatory balance.*\u003csup\u003e11\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eOrder now and join the 200,000+ people who trust ProHealth Sirtuin 6 Activator for their cellular health!\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong style=\"font-size: 1.1em;\"\u003eIngredients:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eBrown Seaweed\u003c\/strong\u003e \u003cem\u003e(Fucus vesiculosus)\u003c\/em\u003e: A rich source of fucoidan, a bioactive polysaccharide recognized for supporting cellular health and activating SIRT6, the longevity enzyme.*\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eReferences:\u003c\/strong\u003e\u003c\/p\u003e\n\u003col\u003e\n\u003cli\u003eRahnasto-Rilla M et al. \u003cem\u003eMar Drugs.\u003c\/em\u003e 2017;15(6):190.\u003c\/li\u003e\n\u003cli\u003eKawaguchi T et al. \u003cem\u003eInt J Oncol\u003c\/em\u003e. 2015;46(5):2216-2222.\u003c\/li\u003e\n\u003cli\u003eYu W et al. Mol Nutr Food Res. 2017;61(10):1700136.\u003c\/li\u003e\n\u003cli\u003eCao L et al. \u003cem\u003eMar Drugs\u003c\/em\u003e. 2020;18(11):564.\u003c\/li\u003e\n\u003cli\u003eLi B et al. \u003cem\u003eMolecules\u003c\/em\u003e. 2008;13(8):1671-1695.\u003c\/li\u003e\n\u003cli\u003eLópez-Otín C et al. \u003cem\u003eCell\u003c\/em\u003e. 2023;186(2):243-278.\u003c\/li\u003e\n\u003cli\u003eIso H and Kubota Y. \u003cem\u003eAsian Pac J Cancer Prev\u003c\/em\u003e. 2007;8 Suppl:35-80.\u003c\/li\u003e\n\u003cli\u003eJayawardena TU et al. \u003cem\u003eMar Drugs\u003c\/em\u003e. 2022;20(12):755.\u003c\/li\u003e\n\u003cli\u003eApostolova E et al. \u003cem\u003ePolymers\u003c\/em\u003e. 2020;12(10):2338.\u003c\/li\u003e\n\u003cli\u003eBogolitsyn K et al. \u003cem\u003ePlant Foods Hum Nutr\u003c\/em\u003e. 2024;79(2):511-517.\u003c\/li\u003e\n\u003cli\u003eLuthuli S et al. \u003cem\u003eMar Drugs\u003c\/em\u003e. 2019;17(9):487.\u003c\/li\u003e\n\u003cli\u003eCatarino MD et al. \u003cem\u003eMar Drugs\u003c\/em\u003e. 2018;16(8):249.\u003c\/li\u003e\n\u003cli\u003eZhang L et al. \u003cem\u003eInnov Aging\u003c\/em\u003e. 2022;6(Suppl 1):130.\u003c\/li\u003e\n\u003cli\u003eMyers S et al. \u003cem\u003eBiol Targets Ther\u003c\/em\u003e. 2011;45.\u003c\/li\u003e\n\u003cli\u003eMyers S. \u003cem\u003eBiol Targets Ther\u003c\/em\u003e. 2010;33.\u003c\/li\u003e\n\u003cli\u003eLi X et al. \u003cem\u003eFront Cell Dev Biol\u003c\/em\u003e. 2021;9:641315.\u003c\/li\u003e\n\u003cli\u003eZhang N et al. \u003cem\u003eCell Cycle.\u003c\/em\u003e 2016;15(7):1009-1018.\u003c\/li\u003e\n\u003cli\u003eChilton WL et al. \u003cem\u003ePLoS ONE\u003c\/em\u003e. 2014;9(4):e92088.\u003c\/li\u003e\n\u003cli\u003eAkter R et al. \u003cem\u003eInt J Mol Sci\u003c\/em\u003e. 2021;22(8):4180.\u003c\/li\u003e\n\u003cli\u003eZhang L et al. \u003cem\u003eInnov Aging\u003c\/em\u003e. 2022;6(Suppl 1):130.\u003c\/li\u003e\n\u003cli\u003eGorbunova V. \u003cem\u003eInnov Aging\u003c\/em\u003e. 2019;3(Suppl 1):S8.\u003c\/li\u003e\n\u003cli\u003eKawamura A et al. \u003cem\u003eMar Drugs\u003c\/em\u003e. 2021;19(8):452.\u003c\/li\u003e\n\u003cli\u003eWillcox DC et al. \u003cem\u003eAnn NY Acad Sci\u003c\/em\u003e. 2009;1173:126-138.\u003c\/li\u003e\n\u003cli\u003eBuettner D. \u003cem\u003eNatl Geogr Books\u003c\/em\u003e. 2015.\u003c\/li\u003e\n\u003cli\u003eKorotkov A et al. \u003cem\u003eTrends Cell Biol\u003c\/em\u003e. 2021;31(12):994-1006.\u003c\/li\u003e\n\u003cli\u003eZhang L et al. \u003cem\u003eOxid Med Cell Longev\u003c\/em\u003e. 2019;2019:8918914.\u003c\/li\u003e\n\u003cli\u003eYang J et al. \u003cem\u003eInt J Biol Macromol.\u003c\/em\u003e 2024;277(Pt 3):134397.\u003c\/li\u003e\n\u003cli\u003eWang K et al. \u003cem\u003eTher Adv Chronic Dis\u003c\/em\u003e. 2022;13:20406223221076891.\u003c\/li\u003e\n\u003c\/ol\u003e\n\n\u003c\/div\u003e\n\u003cdiv class=\"product-label-copy\"\u003e\n\u003ctable width=\"100%\" cellspacing=\"2\" cellpadding=\"0\" border=\"0\" style=\"height: 243.333px;\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 29.9667px;\"\u003e\n\u003cth style=\"font-size: 11pt; font-weight: bold; height: 29.9667px;\" colspan=\"3\" align=\"left\"\u003eSupplement Facts\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 29.0333px;\"\u003e\n\u003ctd class=\"smalltext\" colspan=\"3\" style=\"height: 29.0333px;\"\u003eServing Size: 1 Capsule\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 29.0333px;\"\u003e\n\u003ctd class=\"smalltext\" colspan=\"3\" style=\"height: 29.0333px;\"\u003eServings Per Container: 60\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 29.0333px;\"\u003e\n\u003ctd style=\"font-weight: bold; height: 29.0333px;\" class=\"smalltext\" colspan=\"2\"\u003eAmount Per Serving\u003c\/td\u003e\n\u003ctd style=\"white-space: nowrap; height: 29.0333px;\" class=\"smalltext\" align=\"right\"\u003e\u003cstrong\u003e%DV\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 48.6333px;\"\u003e\n\u003ctd class=\"smalltext\" style=\"height: 48.6333px;\"\u003eFucoidan (from Bladderwrack [\u003cem\u003eFucus vesiculosus\u003c\/em\u003e] Whole Plant Extract and Brown Seaweed [\u003cem\u003eUndaria pinnatifida\u003c\/em\u003e] Whole Plant Extract)\u003c\/td\u003e\n\u003ctd style=\"white-space: nowrap; height: 48.6333px;\" class=\"smalltext\" align=\"right\"\u003e400 mg\u003c\/td\u003e\n\u003ctd style=\"white-space: nowrap; height: 48.6333px;\" class=\"smalltext\" align=\"right\"\u003e†\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 48.6333px;\"\u003e\n\u003ctd class=\"smalltext\" style=\"height: 48.6333px;\"\u003eBladderwrack (\u003cem\u003eFucus vesiculosus\u003c\/em\u003e) Whole Plant Powder\u003c\/td\u003e\n\u003ctd style=\"white-space: nowrap; height: 48.6333px;\" class=\"smalltext\" align=\"right\"\u003e100 mg\u003c\/td\u003e\n\u003ctd style=\"white-space: nowrap; height: 48.6333px;\" class=\"smalltext\" align=\"right\"\u003e†\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 29px;\"\u003e\n\u003ctd class=\"smalltext\" colspan=\"3\" style=\"height: 29px;\"\u003e† Daily Value (DV) not established\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\nREV.10.24\u003cbr\u003e\u003cbr\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eOTHER INGREDIENTS: \u003c\/strong\u003eVegetable cellulose (capsule), microcrystalline cellulose, bamboo silica.\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eMay contain\u003c\/strong\u003e traces of fish and\/or shellfish residue.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSUGGESTED DAILY USE: \u003c\/strong\u003eTake one (1) capsule daily, or as directed by your healthcare professional.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAUTION: \u003c\/strong\u003eFor use by healthy adults only. Please consult your physician before use if you are pregnant or nursing, under the age of 18, or are undergoing treatment for a medical condition. Do not exceed the suggested use. \u003cstrong\u003eKEEP OUT OF REACH OF CHILDREN.\u003c\/strong\u003e Store in a cool and dry place after opening.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e","brand":"ProHealth Wholesale","offers":[{"title":"Default Title","offer_id":52292644536480,"sku":"PH664","price":79.95,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0507\/7588\/3936\/files\/PH664_100CC_FRNT_600x600-Rev1024.png?v=1740437705","url":"https:\/\/wholesale.prohealth.com\/products\/prohealth-sirtuin-6-activator-60-capsules-ph664","provider":"ProHealth Wholesale","version":"1.0","type":"link"}