{"product_id":"prohealth-sirtuin-1-activator-60-capsules-ph665","title":"Sirtuin 1 Activator - 60 capsules","description":"\u003cdiv class=\"product-benefits-copy\"\u003e\n\u003cp\u003e\u003cstrong style=\"font-size: 1.1em;\"\u003eSwitch On the Longevity Gene\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eActivates and supports SIRT1*\u003csup\u003e1-7\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003cli\u003ePromotes healthy aging at the cellular level*\u003csup\u003e2,3,8-11\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003cli\u003eStrengthens the body’s antioxidant network*\u003csup\u003e12\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003cli\u003eHelps maintain metabolic and inflammatory health*\u003csup\u003e13\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003cli\u003eBoosts mitochondrial biogenesis and energy output*\u003csup\u003e1,3\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cspan style=\"color: #0000ff;\"\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0507\/7588\/3936\/files\/PH665_-_COA_Brighton_LOT_26058_2025-11-11_2.pdf?v=1764179037\" rel=\"noopener noreferrer\" style=\"color: #0000ff;\" target=\"_blank\"\u003eView Certificate of Analysis\u003c\/a\u003e\u003cbr\u003e\u003cbr\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong style=\"font-size: 1.1em;\"\u003eThe Science of SIRT1 \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cbr\u003eInside every cell is a guardian protein called sirtuin 1 (SIRT1), short for Silent Information Regulator. It helps decide which parts of your DNA stay quiet and which stay active, helping cells adapt to stress, maintain energy efficiency, and resist the effects of aging.\u003cbr\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003eCommonly known as the \"longevity switch,\" SIRT1 is involved in DNA repair, the removal of damaged cellular components, and the optimization of energy use. As we age, SIRT1 activity naturally declines due to factors such as oxidative stress, poor diet, disrupted sleep, and environmental challenges. This reduction is linked to diminished cellular resilience and many of the classic signs of aging.\u003cbr\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003eThe good news is that certain food compounds can help support SIRT1 function. Plant-derived polyphenols such as resveratrol (from red grapes) and pterostilbene (from blueberries) are among the best-studied for their ability to activate SIRT1 and promote healthy cellular aging. These compounds mimic calorie restriction at the molecular level, helping to reactivate SIRT1 and restore youthful gene expression patterns. By boosting SIRT1 activity, they help shift cells into a protective, repair-focused state, supporting the body’s natural defenses as we age.*\u003csup\u003e1-7\u003cbr\u003e\u003cbr\u003e\u003c\/sup\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong style=\"font-size: 1.1em;\"\u003eWhy Resveratrol + Pterostilbene Work Better Togethe\u003cbr\u003e\u003cbr\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eResveratrol is well-known for supporting SIRT1, but the body clears it fast. The liver converts most of it into inactive metabolites within minutes. Blood levels fall quickly, so only a limited amount reaches cells. The effect on SIRT1 is meaningful, yet short-lived.*\u003csup\u003e1-3,5-7\u003cbr\u003e\u003cbr\u003e\u003c\/sup\u003e\u003c\/p\u003e\n\u003cp\u003ePterostilbene shifts the profile. It is a close relative of resveratrol with two methyl groups that improve its performance.\u003cbr\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eUp to 4× higher oral bioavailability*\u003c\/li\u003e\n\u003cli\u003eGreater lipophilicity for superior cellular penetration*\u003c\/li\u003e\n\u003cli\u003eSignificantly longer half-life in the body (up to 7× longer than resveratrol)*\u003csup\u003e4,14-16\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eWhen used together in a balanced ratio, the two ingredients work in sequence. Resveratrol supports a fast SIRT1 response. Pterostilbene keeps that response active for a longer period due to its greater stability. This provides steadier sirtuin pathway support than resveratrol alone.*\u003csup\u003e1-7,14-16\u003cbr\u003e\u003cbr\u003e\u003c\/sup\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong style=\"font-size: 1.1em;\"\u003eWhat Makes Ours Better?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003e4:1 Polyphenol Complex:\u003c\/strong\u003e Balanced to reflect bioavailability differences between resveratrol and pterostilbene.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eClinically Studied Forms:\u003c\/strong\u003e Includes the active trans form of resveratrol and pterostilbene for consistency and purity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLongevity Pathway Support:\u003c\/strong\u003e Engages SIRT1, AMPK and PGC-1α pathways linked to mitochondrial function and cellular upkeep.*\u003csup\u003e1-7\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMinimalist Formula:\u003c\/strong\u003e Uses only active polyphenols for a straightforward, clean profile.*\u003cbr\u003e\u003cbr\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong style=\"font-size: 1.1em;\"\u003eThe ProHealth Difference\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eDoctor-Formulated:\u003c\/strong\u003e Developed by our in-house science team in collaboration with leading wellness experts.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTriple Lab Tested:\u003c\/strong\u003e Verified three times by independent labs for purity and potency.\u003c\/li\u003e\n\u003cli\u003e \u003cstrong\u003eFull Transparency:\u003c\/strong\u003e Third-party test results published online for complete confidence.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eUSA Manufactured:\u003c\/strong\u003e Proudly manufactured in the USA in FDA-registered, GMP-certified facilities since 1988.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003e100-Day Risk-Free Guarantee:\u003c\/strong\u003e If you’re not fully satisfied, we’ll refund your purchase in full.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong style=\"font-size: 1.1em;\"\u003eA Word from our Chief Science Officer\u003cbr\u003e\u003cbr\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\"Resveratrol brought SIRT1 into the spotlight, but bioavailability has always limited its potential. By combining it with pterostilbene, we’re matching kinetics with biology — ensuring both rapid activation and sustained support of this key longevity pathway.\"\u003cbr\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong style=\"font-size: 1.1em;\"\u003eIngredient Info\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eTrans-Resveratrol:\u003c\/strong\u003e The active, naturally occurring form of resveratrol that supports key cellular pathways involved in healthy aging.*\u003cbr\u003e\u003cstrong\u003eTrans-Pterostilbene:\u003c\/strong\u003e A lipophilic stilbene that engages the SIRT1 pathway and complements resveratrol for steady cellular support.*\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eReferences:\u003c\/strong\u003e\u003c\/p\u003e\n\u003col\u003e\n\u003cli\u003eDella Vedova L et al. \u003cem\u003ePharmaceuticals (Basel)\u003c\/em\u003e. 2025;18(2):138.\u003c\/li\u003e\n\u003cli\u003eZhou DD et al. \u003cem\u003eSubcell Biochem\u003c\/em\u003e. 2024;107:183-203.\u003c\/li\u003e\n\u003cli\u003eLi YR et al. \u003cem\u003eBiofactors\u003c\/em\u003e. 2018;44(1):69-82.\u003c\/li\u003e\n\u003cli\u003eWood JG et al. \u003cem\u003eNature\u003c\/em\u003e. 2004;430(7000):686-689.\u003c\/li\u003e\n\u003cli\u003eKuršvietienė L et al. \u003cem\u003eMedicina\u003c\/em\u003e. 2016;52(3),148-155.\u003c\/li\u003e\n\u003cli\u003eLakshminarasimhan M et al. \u003cem\u003eAging (Albany NY)\u003c\/em\u003e. 2013;5(3),151.\u003c\/li\u003e\n\u003cli\u003eBorra MT et al. \u003cem\u003eJ Biol Chem\u003c\/em\u003e. 2005;280(17),17187-17195.\u003c\/li\u003e\n\u003cli\u003eThaung Zaw JJ et al. \u003cem\u003eClin Nutr\u003c\/em\u003e. 2021;40(3):820-829.\u003c\/li\u003e\n\u003cli\u003eThaung Zaw JJ et al. \u003cem\u003eMenopause.\u003c\/em\u003e 2021;28(1):40-49.\u003c\/li\u003e\n\u003cli\u003eWong RH et al. \u003cem\u003eJ Bone Miner Res\u003c\/em\u003e. 2020;35(11):2121-2131.\u003c\/li\u003e\n\u003cli\u003eThaung Zaw JJ et al. \u003cem\u003eNutrients\u003c\/em\u003e. 2020;12(3):828.\u003c\/li\u003e\n\u003cli\u003eChan EWC et al. \u003cem\u003eJ Appl Pharm Sci.\u003c\/em\u003e 2019;9(7):124-129.\u003c\/li\u003e\n\u003cli\u003eDella Vedova L et a. \u003cem\u003ePharmaceuticals (Basel)\u003c\/em\u003e. 2025;18(2):138.\u003c\/li\u003e\n\u003cli\u003eWang P, Sang S. \u003cem\u003eBiofactors.\u003c\/em\u003e 2018;44(1):16-25.\u003c\/li\u003e\n\u003cli\u003eRiche DM et al.  \u003cem\u003eJ Toxicol\u003c\/em\u003e. 2013;2013:463595.\u003c\/li\u003e\n\u003cli\u003eKapetanovic IM et al. \u003cem\u003eCancer Chemother Pharmacol.\u003c\/em\u003e 2011;68(3):593-601.\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"product-label-copy\"\u003e\n\u003ctable border=\"0\" cellpadding=\"0\" cellspacing=\"2\" width=\"100%\" style=\"height: 275.333px;\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 20.5333px;\"\u003e\n\u003cth align=\"left\" style=\"font-size: 11pt; font-weight: bold; height: 20.5333px;\" colspan=\"3\"\u003eSupplement Facts\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.6px;\"\u003e\n\u003ctd class=\"smalltext\" colspan=\"3\" style=\"height: 19.6px;\"\u003eServing Size: 1 Capsule\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.6px;\"\u003e\n\u003ctd class=\"smalltext\" colspan=\"3\" style=\"height: 19.6px;\"\u003eServings Per Container: 60\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.6px;\"\u003e\n\u003ctd style=\"font-weight: bold; height: 19.6px;\" class=\"smalltext\" colspan=\"2\"\u003eAmount Per Serving\u003c\/td\u003e\n\u003ctd align=\"right\" class=\"smalltext\" style=\"white-space: nowrap; height: 19.6px;\"\u003e\u003cstrong\u003e%DV\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.6px;\"\u003e\n\u003ctd class=\"smalltext\" style=\"height: 19.6px;\"\u003eVeri-te® Trans-Resveratrol\u003c\/td\u003e\n\u003ctd align=\"right\" style=\"white-space: nowrap; height: 19.6px;\" class=\"smalltext\"\u003e200 mg\u003c\/td\u003e\n\u003ctd align=\"right\" style=\"white-space: nowrap; height: 19.6px;\" class=\"smalltext\"\u003e†\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.6px;\"\u003e\n\u003ctd class=\"smalltext\" style=\"height: 19.6px;\"\u003eTrans-Pterostilbene\u003c\/td\u003e\n\u003ctd align=\"right\" style=\"white-space: nowrap; height: 19.6px;\" class=\"smalltext\"\u003e50 mg\u003c\/td\u003e\n\u003ctd align=\"right\" style=\"white-space: nowrap; height: 19.6px;\" class=\"smalltext\"\u003e†\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 39.2px;\"\u003e\n\u003ctd class=\"smalltext\" colspan=\"3\" style=\"height: 39.2px;\"\u003e† Percent Daily Values (DV) not established\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cbr\u003e\n\u003cp\u003eREV.10.25\u003c\/p\u003e\nVeri-te® is a registered trademark of the Lallemand group.\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eOTHER INGREDIENTS: \u003c\/strong\u003eRice flour, hypromellose (capsule).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSUGGESTED DAILY USE: \u003c\/strong\u003eTake one (1) capsule per day with food.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAUTION: \u003c\/strong\u003eFor use by healthy adults only. Please consult your physician before use if you are pregnant or nursing, under the age of 18, or are undergoing treatment for a medical condition. Do not exceed the suggested use. \u003cstrong\u003eKEEP OUT OF REACH OF CHILDREN\u003c\/strong\u003e. Store in a cool and dry place after opening.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e","brand":"ProHealth Wholesale","offers":[{"title":"Default Title","offer_id":53047126982816,"sku":"PH665","price":39.95,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0507\/7588\/3936\/files\/PH665_175CC_FRNT_600x600-REV-1025.png?v=1763681455","url":"https:\/\/wholesale.prohealth.com\/products\/prohealth-sirtuin-1-activator-60-capsules-ph665","provider":"ProHealth Wholesale","version":"1.0","type":"link"}