{"product_id":"prohealth-full-spectrum-apigenin-plus-60-capsules-ph695","title":"Full Spectrum Apigenin Plus - 250 mg, 60 capsules","description":"\u003cdiv class=\"product-benefits-copy\"\u003e\n\u003cp\u003e\u003cstrong style=\"font-size: 1.1em;\"\u003eHarness the Power of Apigenin for Healthy Aging \u003cbr\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eHelps maintain healthy NAD+ levels*\u003csup\u003e1-3\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003cli\u003eProvides antioxidant support to combat oxidative stress*\u003csup\u003e4-7\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003cli\u003eSupports relaxation and sleep quality*\u003csup\u003e8-13\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003cli\u003eTargets key pathways of healthy aging at the cellular level*\u003csup\u003e14-29\u003c\/sup\u003e*\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eApigenin is a potent flavonoid commonly found in chamomile, parsley, and celery that plays a key role in cellular health, relaxation, and longevity. By targeting CD38, a major NAD+-consuming enzyme, apigenin helps sustain optimal NAD+ levels—essential for energy production and healthy aging.*\u003csup\u003e1-3\u003c\/sup\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"color: #0000ff;\"\u003e\u003cbr\u003e\u003ca style=\"color: #0000ff;\" rel=\"noopener noreferrer\" href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0507\/7588\/3936\/files\/PH695_-_COA_Brighton_LOT_2602026_2026.05.13_2.pdf?v=1792426644\" target=\"_blank\"\u003eView Certificate of Analysis\u003c\/a\u003e\u003cbr\u003e\u003cbr\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eUltra-Pure Extract:\u003c\/strong\u003e Apigenin derived from celery (Apium graveolens) seed, delivering exceptional purity and potency, rooted in centuries of traditional use.*\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eClinically Backed Strength:\u003c\/strong\u003e Each capsule provides a potent 250mg dose of apigenin, among the highest available on the market.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFull Spectrum Ingredients:\u003c\/strong\u003e Unlike synthetic apigenin, this blend combines pure plant-derived apigenin with organic parsley powder to deliver a wide spectrum of phytonutrients and co-factors that support optimal activity.*\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eEnhanced Absorption:\u003c\/strong\u003e Features BioPerine® black pepper extract to boost absorption and bioavailability.*\u003csup\u003e30\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong style=\"font-size: 1.1em;\"\u003eWhat Makes Ours Better?\u003cbr\u003e\u003cbr\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eDoctor-Formulated:\u003c\/strong\u003e Developed by our in-house science team in collaboration with leading wellness experts to address the root causes of aging.* \u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTriple Lab Tested:\u003c\/strong\u003e Subjected to three rounds of independent third-party lab testing to ensure unmatched potency and purity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFull Transparency:\u003c\/strong\u003e In an industry full of misleading claims, we publish our third-party lab results—so you always know exactly what’s in every bottle.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eUSA Manufacturing Excellence:\u003c\/strong\u003e Made in FDA-regulated, GMP-certified facilities in the USA for the highest quality and safety standards.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003e100-Day Risk-Free Guarantee:\u003c\/strong\u003e We're confident you’ll love our product. If you're not satisfied, contact our Santa Barbara, CA office for a full refund within 100 days—no hassle, no questions asked. \u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eApigenin is a naturally occurring flavonoid found in a variety of fruits, vegetables, and herbs. Its therapeutic potential is highlighted by human clinical studies on chamomile extract, which contains apigenin as a key active ingredient. Recognized for its broad-spectrum benefits, apigenin has gained attention for its role in supporting relaxation and sleep quality. It interacts with GABA receptors in the brain, helping to foster a calm state of mind and support healthy sleep patterns—critical factors for long-term health and cognitive function.*\u003csup\u003e31\u003cbr\u003e\u003cbr\u003e\u003c\/sup\u003eOne of apigenin's key mechanisms involves targeting CD38, an enzyme responsible for depleting NAD+, a vital molecule for energy production and cellular repair. By balancing CD38 activity, apigenin helps maintain healthy NAD+ levels, supporting mitochondrial function, DNA integrity, and overall cellular resilience as the body ages. Additionally, apigenin offers powerful antioxidant effects, neutralizing free radicals and reducing oxidative stress—both major contributors to aging and age-related decline.*\u003csup\u003e1-3\u003cbr\u003e\u003cbr\u003e\u003c\/sup\u003eBy addressing several hallmarks of aging and supporting the core pillars of health, apigenin emerges as a powerful compound for those aiming to optimize their health and longevity.*\u003cbr\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong style=\"font-size: 1.1em;\"\u003eFeel the Difference with Full Spectrum Apigenin\u003cbr\u003e\u003cbr\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eHelps maintain healthy NAD+ levels*\u003cbr\u003e\u003c\/strong\u003eApigenin indirectly boosts NAD+ levels by targeting CD38, a glycoprotein that consumes NAD+ during cellular processes. Research shows that mice either lacking CD38 or supplemented with apigenin have approximately 50% higher NAD+ levels, underscoring apigenin’s role in NAD+ metabolism. As CD38 activity naturally increases with age, accelerating NAD+ decline, apigenin offers a unique way to counteract this process. When paired with NAD+ precursors like NR or NMN, apigenin further optimizes NAD+ metabolism, providing additional support for cellular health and vitality.*\u003csup\u003e1-3\u003cbr\u003e\u003cbr\u003e\u003c\/sup\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eProvides antioxidant support to combat oxidative stress*\u003c\/strong\u003e\u003cbr\u003eApigenin, like other powerful flavonoids such as quercetin, rutin, luteolin, and EGCG, offers robust antioxidant protection, helping plants combat UV radiation, environmental stress, and free radicals. In the human body, apigenin’s electron-rich flavonoid structure performs a similar protective function—neutralizing free radicals and boosting antioxidant pathways. This support helps promote cellular health, longevity, and overall resilience against oxidative damage.*\u003csup\u003e4-7\u003cbr\u003e\u003cbr\u003e\u003c\/sup\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSupports relaxation and sleep quality*\u003c\/strong\u003e\u003cbr\u003eApigenin is well-known for its ability to support relaxation and sleep quality. Research shows that higher dietary apigenin intake is linked to better sleep quality. It works by activating chloride ion channels and modulating GABAergic pathways in the brain, helping to calm neuronal activity and induce a deeper state of relaxation. Additionally, apigenin plays a role in supporting healthy cortisol levels, reducing the impact of stress and encouraging balanced, restorative sleep patterns.*\u003csup\u003e8-13\u003cbr\u003e\u003cbr\u003e\u003c\/sup\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eTargets key pathways of healthy aging at the cellular level*\u003c\/strong\u003e\u003cbr\u003eBeyond its role in maintaining NAD+ levels—and its downstream activation of sirtuins and PARPs—apigenin plays a crucial part in cellular renewal. It helps activate autophagy, the body's natural cellular repair process that maintains healthy cell function. Additionally, apigenin has been shown to combat cellular senescence by acting as a senolytic agent, aiding in the clearance of senescent cells while buffering the effects of senescence-associated secretory phenotype (SASP) factors.*\u003csup\u003e14,15\u003cbr\u003e\u003cbr\u003e\u003c\/sup\u003e\u003c\/p\u003e\n\u003cp\u003eBeyond these core actions, apigenin influences numerous other longevity pathways, including AMPK, PPARα\/γ, SIRT-1, mTOR, IGF-1, immune signaling, and NF-κB, helping to optimize cellular health across multiple systems.*\u003csup\u003e16-29\u003cbr\u003e\u003cbr\u003e\u003c\/sup\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eNew and noteworthy\u003c\/strong\u003e\u003cbr\u003eApigenin is highly active in the body, with emerging research highlighting its potential to provide a range of benefits, including neuroprotection, cardiovascular support, and metabolic health. Scientists are actively exploring its full therapeutic profile.*\u003csup\u003e1,17,20,28,32-36\u003cbr\u003e\u003cbr\u003e\u003c\/sup\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong style=\"font-size: 1.1em;\"\u003eExperience nature's calming bioflavonoid—the perfect stack to elevate your wellness routine.* \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eOrder now and join the thousands of people who trust ProHealth for their longevity journey!\u003cbr\u003e\u003cbr\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong style=\"font-size: 1.1em;\"\u003eIngredients:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eApigenin:\u003c\/strong\u003e A powerful bioflavonoid compound found in chamomile, known for its ability to support relaxation and boost NAD+.*\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eOrganic Parsley:\u003c\/strong\u003e A source of complementary phytonutrients that amplify the full-spectrum benefits of the formula.*\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBioPerine® Black Pepper:\u003c\/strong\u003e A patented extract that boosts the absorption and bioavailability of key ingredients.*\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eReferences:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003csup\u003e1 \u003c\/sup\u003eEscande C et al. \u003cem\u003eDiabetes\u003c\/em\u003e. 2013;62(4):1084-1093. \u003cbr\u003e\u003csup\u003e2 \u003c\/sup\u003eOgura Y et al. \u003cem\u003eAging\u003c\/em\u003e.12(12), 11325–11336.\u003cbr\u003e\u003csup\u003e3 \u003c\/sup\u003eKellenberger E et al. \u003cem\u003eBioorg Med Chem Lett\u003c\/em\u003e. 2011;21(13):3939-3942. \u003cbr\u003e\u003csup\u003e4 \u003c\/sup\u003eAhmad A et al. \u003cem\u003eFood Chem Toxicol\u003c\/em\u003e. 2019;127:218-227.\u003cbr\u003e\u003csup\u003e5 \u003c\/sup\u003eAbid R et al. \u003cem\u003eMolecules\u003c\/em\u003e. 2022;27(13):4304. \u003cbr\u003e\u003csup\u003e6 \u003c\/sup\u003eKashyap P et al. \u003cem\u003eJ Food Biochem\u003c\/em\u003e. 2022;46(4). \u003cbr\u003e\u003csup\u003e7 \u003c\/sup\u003eSingh A et al. \u003cem\u003eCrit Rev Food Sci Nutr\u003c\/em\u003e. 2024;8(17):1-37.\u003cbr\u003e\u003csup\u003e8 \u003c\/sup\u003eKim J et al. \u003cem\u003eArchives of Pharmacal Research\u003c\/em\u003e. 35(2), 367–373. \u003cbr\u003e\u003csup\u003e9 \u003c\/sup\u003eAmsterdam JD et al. \u003cem\u003eJ Clin Psychopharmacol\u003c\/em\u003e. 2009;29(4):378-382. \u003cbr\u003e\u003csup\u003e10 \u003c\/sup\u003eGodos J et al. \u003cem\u003eNutrients.\u003c\/em\u003e 2020;12(5):1226. \u003cbr\u003e\u003csup\u003e11 \u003c\/sup\u003eViola H et al. \u003cem\u003ePlanta Med\u003c\/em\u003e. 1995;61(3):213-216.\u003cbr\u003e\u003csup\u003e12 \u003c\/sup\u003eOhno S et al. \u003cem\u003eJ Steroid Biochem Mol Biol.\u003c\/em\u003e 2002;80(3):355-363. \u003cbr\u003e\u003csup\u003e13 \u003c\/sup\u003eCheng LC et al. \u003cem\u003eToxicol Appl Pharmacol.\u003c\/em\u003e 2012;258(3):343-350.\u003cbr\u003e\u003csup\u003e14 \u003c\/sup\u003eLu J et al. \u003cem\u003eFood Funct\u003c\/em\u003e. 2020;11(10):9208-9215.\u003cbr\u003e\u003csup\u003e15 \u003c\/sup\u003eFan X et al. \u003cem\u003eInt J Mol Sci\u003c\/em\u003e. 2022;23(4):2176.\u003cbr\u003e\u003csup\u003e16 \u003c\/sup\u003eChoi WH et al. \u003cem\u003eMol Nutr Food Res\u003c\/em\u003e. 2017;61.\u003cbr\u003e\u003csup\u003e17 \u003c\/sup\u003eWong TY et al. Biomed Pharmacother. 2017;96:1000–1007.\u003cbr\u003e\u003csup\u003e18 \u003c\/sup\u003eOno K et al. \u003cem\u003eJ Agric Food Chem\u003c\/em\u003e. 2011;59:13346–13352. \u003cbr\u003e\u003csup\u003e19 \u003c\/sup\u003eWei X et al. \u003cem\u003eClin Sci\u003c\/em\u003e. 2017;131:567–581. \u003cbr\u003e\u003csup\u003e20 \u003c\/sup\u003eMahajan UB et al. \u003cem\u003eInt J Mol Sci\u003c\/em\u003e. 2017;18.\u003cbr\u003e\u003csup\u003e21 \u003c\/sup\u003eWang F et al. \u003cem\u003eChem Biol Interact.\u003c\/em\u003e 2017;275:171–177. \u003cbr\u003e\u003csup\u003e22 \u003c\/sup\u003eYu W et al. \u003cem\u003eEvid Based Complement Alternat Med.\u003c\/em\u003e 2017;2017:2590676.\u003cbr\u003e\u003csup\u003e23 \u003c\/sup\u003eTong X et al. \u003cem\u003eMol Carcinog.\u003c\/em\u003e 2012;51:268–279. \u003cbr\u003e\u003csup\u003e24 \u003c\/sup\u003eBridgeman BB et al. \u003cem\u003eCell Signal\u003c\/em\u003e. 2016;28:460–468. \u003cbr\u003e\u003csup\u003e25 \u003c\/sup\u003eBabcook MA et al. \u003cem\u003eCurr. Drug Targets.\u003c\/em\u003e 2012.\u003cbr\u003e\u003csup\u003e26 \u003c\/sup\u003eShukla S et al. \u003cem\u003ePharm Res.\u003c\/em\u003e 2012;29:1506–1517.  \u003cbr\u003e\u003csup\u003e27 \u003c\/sup\u003eCardenas H et al. \u003cem\u003eInt J Mol Sci\u003c\/em\u003e. 2016;17:323. \u003cbr\u003e\u003csup\u003e28 \u003c\/sup\u003eRen B et al. \u003cem\u003eEur J Pharmacol\u003c\/em\u003e. 2016;773:13–23.\u003cbr\u003e\u003csup\u003e29 \u003c\/sup\u003eKim A et al. \u003cem\u003eArch Pharmacol\u003c\/em\u003e. 2018;391:271–283.\u003cbr\u003e\u003csup\u003e30 \u003c\/sup\u003eDudhatra GB et al. \u003cem\u003eScientific World Journal\u003c\/em\u003e. 2012;2012:637953. \u003cbr\u003e\u003csup\u003e31 \u003c\/sup\u003eKramer DJ et al. \u003cem\u003eFront Nutr\u003c\/em\u003e. 2024;11:1359176. \u003cbr\u003e\u003csup\u003e32 \u003c\/sup\u003eNabavi SF et al. \u003cem\u003ePharmacol Res\u003c\/em\u003e. 2018;128:359-365. \u003cbr\u003e\u003csup\u003e33 \u003c\/sup\u003eHan Y et al. J. \u003cem\u003eClin. Neurosci.\u003c\/em\u003e 2017;40:157–162.\u003cbr\u003e\u003csup\u003e34 \u003c\/sup\u003eZhang F et al. \u003cem\u003eNeurol Sci.\u003c\/em\u003e 2014;35:583–588. \u003cbr\u003e\u003csup\u003e35 \u003c\/sup\u003eZhao L et al. \u003cem\u003eMolecules.\u003c\/em\u003e 2013;18:9949–9965.  \u003cbr\u003e\u003csup\u003e36 \u003c\/sup\u003eJung UJ et al. \u003cem\u003eNutrients.\u003c\/em\u003e 2016;8(5):305. \u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"product-label-copy\"\u003e\n\u003ctable style=\"height: 275.333px;\" border=\"0\" cellpadding=\"0\" cellspacing=\"2\" width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 20.5333px;\"\u003e\n\u003cth align=\"left\" colspan=\"3\" style=\"font-size: 11pt; font-weight: bold; height: 20.5333px;\"\u003eSupplement Facts\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.6px;\"\u003e\n\u003ctd style=\"height: 19.6px;\" colspan=\"3\" class=\"smalltext\"\u003eServing Size: 1 Capsule\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.6px;\"\u003e\n\u003ctd style=\"height: 19.6px;\" colspan=\"3\" class=\"smalltext\"\u003eServings Per Container: 60\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.6px;\"\u003e\n\u003ctd colspan=\"2\" class=\"smalltext\" style=\"font-weight: bold; height: 19.6px;\"\u003eAmount Per Serving\u003c\/td\u003e\n\u003ctd align=\"right\" class=\"smalltext\" style=\"white-space: nowrap; height: 19.6px;\"\u003e\u003cstrong\u003e%DV\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.6px;\"\u003e\n\u003ctd style=\"height: 19.6px;\" class=\"smalltext\"\u003eOrganic Parsley Powder (\u003cem\u003ePetroselinum crispum\u003c\/em\u003e)\u003c\/td\u003e\n\u003ctd align=\"right\" class=\"smalltext\" style=\"white-space: nowrap; height: 19.6px;\"\u003e350 mg\u003c\/td\u003e\n\u003ctd align=\"right\" class=\"smalltext\" style=\"white-space: nowrap; height: 19.6px;\"\u003e†\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.6px;\"\u003e\n\u003ctd style=\"height: 19.6px;\" class=\"smalltext\"\u003eNatural Apigenin (\u003cem\u003eApium graveolens\u003c\/em\u003e extract 98%)\u003c\/td\u003e\n\u003ctd align=\"right\" class=\"smalltext\" style=\"white-space: nowrap; height: 19.6px;\"\u003e250 mg\u003c\/td\u003e\n\u003ctd align=\"right\" class=\"smalltext\" style=\"white-space: nowrap; height: 19.6px;\"\u003e†\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.6px;\"\u003e\n\u003ctd style=\"height: 19.6px;\" class=\"smalltext\"\u003eBlack Pepper (piperine) (\u003cem\u003ePiper nigrum\u003c\/em\u003e extract 95%)\u003c\/td\u003e\n\u003ctd align=\"right\" class=\"smalltext\" style=\"white-space: nowrap; height: 19.6px;\"\u003e3.5 mg\u003c\/td\u003e\n\u003ctd align=\"right\" class=\"smalltext\" style=\"white-space: nowrap; height: 19.6px;\"\u003e†\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.6px;\"\u003e\n\u003ctd style=\"height: 19.6px;\" colspan=\"3\" class=\"smalltext\"\u003e†Daily Value (DV) not established\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\nREV.10.24\u003cbr\u003e\u003cbr\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eSUGGESTED DAILY USE: \u003c\/strong\u003eTake one (1) capsule daily with food, or as recommended by your healthcare professional.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eOTHER INGREDIENTS\u003c\/strong\u003e:\u003cstrong\u003e \u003c\/strong\u003eVegetable cellulose (capsule). \u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eDOES NOT CONTAIN\u003c\/strong\u003e:\u003cstrong\u003e \u003c\/strong\u003eDairy, egg, soy, wheat, gluten, corn, fish, shellfish, tree nuts, peanuts.\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAUTION: \u003c\/strong\u003eFor use by healthy adults only. Please consult your physician before use if you are pregnant or nursing, under the age of 18, or are undergoing treatment for a medical condition. Do not exceed the suggested use. \u003cstrong\u003eKEEP OUT OF REACH OF CHILDREN\u003c\/strong\u003e. Store in a cool and dry place after opening.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e","brand":"ProHealth Wholesale","offers":[{"title":"Default Title","offer_id":52287374655648,"sku":"PH695","price":45.74,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0507\/7588\/3936\/files\/PH695_175CC_FRNT_600x600-REV-1024.png?v=1740179948","url":"https:\/\/wholesale.prohealth.com\/products\/prohealth-full-spectrum-apigenin-plus-60-capsules-ph695","provider":"ProHealth Wholesale","version":"1.0","type":"link"}