{"product_id":"prohealth-calcium-akg-longevity-500-mg-60-capsules-ph591","title":"Calcium AKG Longevity - 1,000 mg per serving, 60 capsules","description":"\u003cdiv class=\"product-benefits-copy\"\u003e\n\u003ch3\u003eSupport Energy Production, Bone Strength, and Metabolic Function With Age\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eSupports healthy aging processes\u003c\/li\u003e\n\u003cli\u003eSupports heart, bone, and metabolic health\u003c\/li\u003e\n\u003cli\u003eSupports cognitive vitality\u003c\/li\u003e\n\u003cli\u003eHelps to boost antioxidant levels inside cells\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cspan style=\"color: #0000ff;\"\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0507\/7588\/3936\/files\/PH591_-_COA_Brighton_LOT_2605063_2026.10.21_2.pdf?v=1792700481\" rel=\"noopener noreferrer\" style=\"color: #0000ff;\" target=\"_blank\"\u003eView Certificate of Analysis \u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003ch3\u003eResearch-Supported Benefits:\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003ePromotes Metabolic Function and Longevity:\u003c\/strong\u003e Alpha-ketoglutarate (AKG) is a compound that is created naturally in the body but tends to diminish with age. In supplement form, AKG can be attached to a calcium salt (Ca-AKG), which has been studied for its role in supporting metabolic function and longevity. (1)\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eStimulates Autophagy:\u003c\/strong\u003e Autophagy, our internal recycling process that removes dysfunctional cells, decreases with age. Ca-AKG has been found to support this process. (2)\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eAides in Bone and Muscle Health:\u003c\/strong\u003e Ca-AKG is involved in stimulating protein synthesis and energy production in the body, as it is a vital component of the Krebs cycle - the process that creates ATP (energy) from food. Ca-AKG is also a source of the essential amino acids needed to make collagen, which is a protein that helps to support bone and muscle health. (3)\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSupports Blood Sugar Regulation:\u003c\/strong\u003e As we age, our bodies become less efficient at regulating blood sugar. Research shows that Ca-AKG can help to support healthy blood sugar levels. (3)\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSupports Cellular Health:\u003c\/strong\u003e The mitochondria, our cells’ main energy hub decreases with age leading to aging and numerous age-related health concerns. Ca-AKG has been found to activate AMPK a pathway that helps maintain cellular energy and support cellular function. (3)\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eImproves Antioxidant Levels:\u003c\/strong\u003e Ca-AKG has also been shown to boost cellular antioxidant levels in aged mice, which helped support the mice’s blood vessel elasticity - a measure of good cardiovascular health. (4)\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eReferences:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e1. Asadi Shahmirzadi A, Edgar D, Liao CY, et al. Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice. Cell Metab. 2020;32(3):447-456.e6. doi:10.1016\/j.cmet.2020.08.004 \u003cbr\u003e\u003cbr\u003e2. Chin R, Fu X, Pai M., et al. The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR. Nature. 2014;510:397–40. https:\/\/doi.org\/10.1038\/nature13264 \u003cbr\u003e\u003cbr\u003e3. Wu N, Yang M, Gaur U, Xu H, Yao Y, Li D. Alpha-Ketoglutarate: Physiological Functions and Applications. Biomol Ther (Seoul). 2016;24(1):1-8. doi:10.4062\/biomolther.2015.078 \u003cbr\u003e\u003cbr\u003e4. Niemiec T, Sikorska J, Harrison A, et al. Alpha-ketoglutarate stabilizes redox homeostasis and improves arterial elasticity in aged mice. J Physiol Pharmacol. 2011;62(1):37-43. \u003cbr\u003e\u003cbr\u003e5. Demidenko O, Barardo D, Budovskii V, et al. Rejuvant®, a potential life-extending compound formulation with alpha-ketoglutarate and vitamins, conferred an average 8 year reduction in biological aging, after an average of 7 months of use, in the TruAge DNA methylation test. Aging (Albany NY). 2021;13(22):24485-24499. doi:10.18632\/aging.203736 \u003cbr\u003e\u003cbr\u003e6. Wu N, Yang M, Gaur U, Xu H, Yao Y, Li D. Alpha-Ketoglutarate: Physiological Functions and Applications. Biomol Ther (Seoul). 2016;24(1):1-8. doi:10.4062\/biomolther.2015.078 \u003cbr\u003e\u003cbr\u003e7. Wang Y, Deng P, Liu Y, et al. Alpha-ketoglutarate ameliorates age-related osteoporosis via regulating histone methylations. Nat Commun. 2020;11(1):5596. Published 2020 Nov 5. doi:10.1038\/s41467-020-19360- \u003cbr\u003e\u003cbr\u003e8. Niemiec T, Sikorska J, Harrison A, et al. Alpha-ketoglutarate stabilizes redox homeostasis and improves arterial elasticity in aged mice. J Physiol Pharmacol. 2011;62(1):37-43. \u003cbr\u003e\u003cbr\u003e9. Wu N, Yang M, Gaur U, Xu H, Yao Y, Li D. Alpha-Ketoglutarate: Physiological Functions and Applications. Biomol Ther (Seoul). 2016;24(1):1-8. doi:10.4062\/biomolther.2015.078 \u003cbr\u003e\u003cbr\u003e10. Asadi Shahmirzadi A, Edgar D, Liao CY, et al. Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice. Cell Metab. 2020;32(3):447-456.e6. doi:10.1016\/j.cmet.2020.08.004 \u003cbr\u003e\u003cbr\u003e11. Chin R, Fu X, Pai M., et al. The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR. Nature. 2014;510:397–40. https:\/\/doi.org\/10.1038\/nature13264\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"product-label-copy\"\u003e\n\u003ctable style=\"height: 158.733px;\" width=\"100%\" cellspacing=\"2\" cellpadding=\"0\" border=\"0\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 20.5333px;\"\u003e\n\u003cth style=\"font-size: 11pt; font-weight: bold; height: 20.5333px;\" colspan=\"3\" align=\"left\"\u003eSupplement Facts\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 18.15px;\"\u003e\n\u003ctd style=\"height: 18.15px;\" class=\"smalltext\" colspan=\"3\"\u003eServing Size: 2 Capsules\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 17.15px;\"\u003e\n\u003ctd style=\"height: 17.15px;\" class=\"smalltext\" colspan=\"3\"\u003eServings Per Container: 30\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 17.15px;\"\u003e\n\u003ctd style=\"font-weight: bold; height: 17.15px;\" class=\"smalltext\" colspan=\"2\"\u003eAmount Per Serving\u003c\/td\u003e\n\u003ctd style=\"white-space: nowrap; height: 17.15px;\" class=\"smalltext\" align=\"right\"\u003e\u003cstrong\u003e%DV\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 34.3px;\"\u003e\n\u003ctd style=\"height: 34.3px;\" class=\"smalltext\"\u003eCalcium\u003cbr\u003e  (as Alpha Ketoglutarate)\u003c\/td\u003e\n\u003ctd style=\"white-space: nowrap; height: 34.3px;\" class=\"smalltext\" align=\"right\"\u003e180 mg\u003c\/td\u003e\n\u003ctd style=\"white-space: nowrap; height: 34.3px;\" class=\"smalltext\" align=\"right\"\u003e14%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 34.3px;\"\u003e\n\u003ctd style=\"height: 34.3px;\" class=\"smalltext\"\u003eCalcium Alpha Ketoglutarate)\u003c\/td\u003e\n\u003ctd style=\"white-space: nowrap; height: 34.3px;\" class=\"smalltext\" align=\"right\"\u003e1000 mg\u003c\/td\u003e\n\u003ctd style=\"white-space: nowrap; height: 34.3px;\" class=\"smalltext\" align=\"right\"\u003e†\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 17.15px;\"\u003e\n\u003ctd style=\"height: 17.15px;\" class=\"smalltext\" colspan=\"3\"\u003e† Daily Value (DV) not established.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\nREV.10.25 \u003cbr\u003e\u003cbr\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eOTHER INGREDIENTS:\u003c\/strong\u003e Hypromellose (capsule), rice flour.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSUGGESTED DAILY USE:\u003c\/strong\u003e Take two (2) capsules in the morning, with or without food, for daily energy\u003cbr\u003esupport. Or take four (4) capsules 30-60 minutes before exercise for athletic support.*\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAUTION:\u003c\/strong\u003e Please consult your physician before use if you are pregnant or nursing, under the age of 18, or are undergoing treatment for a medical condition. Do not exceed the suggested use. \u003cstrong\u003eKEEP OUT OF REACH OF CHILDREN\u003c\/strong\u003e. Store in a cool and dry place.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"product-how-it-work-copy\"\u003e\n\u003cul\u003e\n\u003cli\u003eAlpha-ketoglutarate (AKG) is a compound that is created naturally in the body but tends to diminish with age. In supplement form, AKG can be attached to a calcium salt (Ca-AKG), which has been studied for its role in supporting metabolic function and longevity. \u003csup\u003e6\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003cli\u003eCa-AKG is involved in stimulating protein synthesis and energy production in the body, as it is a vital component of the Krebs cycle - the process that creates ATP (energy) from food. Ca-AKG is also a source of the essential amino acids needed to make collagen, which is a protein that helps to support bone and muscle health.\u003c\/li\u003e\n\u003cli\u003eCa-AKG facilitates our internal recycling process known as autophagy, which removes dysfunctional cells, cell parts and proteins from the body. Autophagy tends to decrease with age, so Ca-AKG may be able to help support this process.\u003c\/li\u003e\n\u003cli\u003eAdding calcium to AKG helps to slow the absorption of AKG allowing it to work longer in the body.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"summary-copy\"\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eBetter Absorption.\u003c\/strong\u003e Compared to other products that commonly use unbound AKG or AKG bound to arginine, our AKG is bound to calcium. This combination has been shown to promote extended lifespan and health span in mice, even when administered late in life. It also helps to slow the absorption allowing it to work longer in the body.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eResearch-Supported.\u003c\/strong\u003e Calcium AKG Longevity is formulated using 1,000 mg of calcium alpha ketoglutarate, which has been shown in clinical research to promote longevity by reversing biological age (measured by biological age tests), improve markers of heart health and decrease risk of age-related decline in bone health.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eQuality Manufacturing Practices.\u003c\/strong\u003e All of our products are manufactured in an FDA-registered, GMP-certified facility.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eThird-Party Tested in the USA.\u003c\/strong\u003e Every batch is third-party tested in US laboratories to ensure the highest quality, purity and potency. Certificates of Analysis are available.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e","brand":"ProHealth Wholesale","offers":[{"title":"Default Title","offer_id":42860943016096,"sku":"PH591","price":25.25,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0507\/7588\/3936\/files\/PH591_FRNT_175ML_600x600_d69eba00-2fa4-413d-b522-4349d16052df.png?v=1770390977","url":"https:\/\/wholesale.prohealth.com\/products\/prohealth-calcium-akg-longevity-500-mg-60-capsules-ph591","provider":"ProHealth Wholesale","version":"1.0","type":"link"}