{"title":"Sirtuin Activation","description":"","products":[{"product_id":"prohealth-pure-trans-resveratrol-powder-1000-mg-30-grams-ph576","title":"Pure Trans-Resveratrol Powder - 30 grams","description":"\u003cdiv class=\"product-benefits-copy\"\u003e\n\n\u003ch2\u003eSupports brain, cardiovascular, cellular and joint health\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eSupports brain health and cognitive function \u003c\/li\u003e\n\u003cli\u003eSupports cellular and DNA health \u003c\/li\u003e\n\u003cli\u003eSupports healthy aging \u003c\/li\u003e\n\u003cli\u003eSupports heart and metabolic health \u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cspan style=\"color: #0000ff;\"\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0507\/7588\/3936\/files\/PH576_-_COA_Brighton_LOT_26387_2026.07.20_2.pdf?v=1792705748\" rel=\"noopener noreferrer\" style=\"color: #0000ff;\" target=\"_blank\"\u003eView Certificate of Analysis \u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003ch3\u003eResearch-Supported Benefits:\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eSupports Brain Health.\u003c\/strong\u003e Research shows that resveratrol, a molecule found in red grapes and wine, may protect the brain from symptoms of brain aging, including improving memory and delaying cognitive decline. The neuroprotective effects of resveratrol come from its sirtuin-activating, inflammation-regulating, mitochondrial-supporting and antioxidant activity.\u003csup\u003e1-3\u003c\/sup\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSupports Cellular and DNA Health.\u003c\/strong\u003e Resveratrol acts as a potent antioxidant, which reduces harmful oxidative stress. It also activates genes called sirtuins. Healthy sirtuin activity helps to fight cellular senescence, support DNA repair, boost mitochondrial function and generate cellular energy through ATP production.\u003csup\u003e3,4\u003c\/sup\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSupports Healthy Aging.\u003c\/strong\u003e Resveratrol activates SIRT1, often referred to as the \"longevity gene.\" Healthy older adults tend to have higher levels of SIRT1 activity, and SIRT1 overexpression can increase lifespan in worms and animals. In humans, SIRT1 supports healthy aging and longevity.\u003csup\u003e5,6\u003c\/sup\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSupports Joint Health.\u003c\/strong\u003e Due to its role in supporting healthier inflammatory responses and modulating oxidative stress, resveratrol has exhibited joint-protective effects.\u003csup\u003e7 \u003c\/sup\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSupports Heart Health.\u003c\/strong\u003e Resveratrol is well-known for its link to supporting cardiovascular health. Research has found that resveratrol benefits endothelial function, blood vessel health and blood pressure by boosting SIRT1 activity, reducing oxidative stress and increasing nitric oxide production.\u003csup\u003e8,9\u003c\/sup\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSupports Metabolic Health.\u003c\/strong\u003e Resveratrol activates SIRT1, which has been studied for its role in supporting healthier glucose metabolism. People with reduced SIRT1 expression tend to have higher blood sugar, poor glucose control and metabolic disorders.\u003csup\u003e10\u003c\/sup\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eReferences:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e1. Salehi B, Mishra AP, Nigam M, et al. Resveratrol: A Double-Edged Sword in Health Benefits. Biomedicines. 2018;6(3):91. Published 2018 Sep 9.\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6164842\/\" style=\"color: #0000ff;\" target=\"_blank\"\u003edoi:10.3390\/biomedicines6030091 \u003c\/a\u003e\u003cbr\u003e\u003cbr\u003e2. Bastianetto S, Ménard C, Quirion R. Neuroprotective action of resveratrol. Biochim Biophys Acta. 2015;1852(6):1195-1201. doi:10.1016\/j.bbadis.2014.09.011 \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25281824\/\" style=\"color: #0000ff;\" target=\"_blank\"\u003edoi:10.1016\/j.bbadis.2014.09.011 \u003c\/a\u003e\u003cbr\u003e\u003cbr\u003e3. Moraes DS, Moreira DC, Andrade JMO, Santos SHS. Sirtuins, brain and cognition: A review of resveratrol effects. IBRO Rep. 2020;9:46-51. Published 2020 Jun 26. \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7733131\/?report=reader\" style=\"color: #0000ff;\" target=\"_blank\"\u003edoi:10.1016\/j.ibror.2020.06.004 \u003c\/a\u003e\u003cbr\u003e\u003cbr\u003e4. Borra MT, Smith BC, Denu JM. Mechanism of human SIRT1 activation by resveratrol. J Biol Chem. 2005;280(17):17187-17195. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/15749705\/\" style=\"color: #0000ff;\" target=\"_blank\"\u003edoi:10.1074\/jbc.M501250200 \u003c\/a\u003e\u003cbr\u003e\u003cbr\u003e5. Kilic U, Gok O, Erenberk U, et al. A remarkable age-related increase in SIRT1 protein expression against oxidative stress in elderly: SIRT1 gene variants and longevity in human. PLoS One. 2015;10(3):e0117954. Published 2015 Mar 18. \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4365019\/\" style=\"color: #0000ff;\" target=\"_blank\"\u003edoi:10.1371\/journal.pone.0117954 \u003c\/a\u003e\u003cbr\u003e\u003cbr\u003e6. Salminen A, Kaarniranta K. SIRT1: regulation of longevity via autophagy. Cell Signal. 2009;21(9):1356-1360. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/19249351\/\" style=\"color: #0000ff;\" target=\"_blank\"\u003edoi:10.1016\/j.cellsig.2009.02.014 \u003c\/a\u003e\u003cbr\u003e\u003cbr\u003e7. Nguyen C, Savouret JF, Widerak M, Corvol MT, Rannou F. Resveratrol, Potential Therapeutic Interest in Joint Disorders: A Critical Narrative Review. Nutrients. 2017;9(1):45. Published 2017 Jan 6. \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5295089\/?report=classic\" style=\"color: #0000ff;\" target=\"_blank\"\u003edoi:10.3390\/nu9010045 \u003c\/a\u003e\u003cbr\u003e\u003cbr\u003e8. Marques BCAA, Trindade M, Aquino JCF, et al. Beneficial effects of acute trans-resveratrol supplementation in treated hypertensive patients with endothelial dysfunction. Clin Exp Hypertens. 2018;40(3):218-223. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29431520\/\" style=\"color: #0000ff;\" target=\"_blank\"\u003edoi:10.1080\/10641963.2017.1288741 \u003c\/a\u003e\u003cbr\u003e\u003cbr\u003e9. Bonnefont-Rousselot D. Resveratrol and Cardiovascular Diseases. Nutrients. 2016;8(5):250. Published 2016 May 2. \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4882663\/\" style=\"color: #0000ff;\" target=\"_blank\"\u003edoi:10.3390\/ijms20030535 \u003c\/a\u003e\u003cbr\u003e\u003cbr\u003eHou CY, Tain YL, Yu HR, Huang LT. The Effects of Resveratrol in the Treatment of Metabolic Syndrome. Int J Mol Sci. 2019;20(3):535. Published 2019 Jan 28. \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6387422\/\" style=\"color: #0000ff;\" target=\"_blank\"\u003edoi:10.3390\/ijms20030535 \u003c\/a\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"product-how-it-work-copy\"\u003e\n\u003cul\u003e\n\u003cli\u003eResveratrol is a naturally occurring polyphenol that works by activating longevity genes called sirtuins, acting as an antioxidant, regulating inflammatory responses and supporting mitochondrial health.  \u003c\/li\u003e\n\u003cli\u003eTrans-resveratrol is the most bioavailable form of resveratrol.  \u003c\/li\u003e\n\u003cli\u003eProHealth's Micronized Trans-Resveratrol powder delivers 1000 mg of pharmaceutical grade, 98% pure, natural trans-resveratrol per serving. \u003c\/li\u003e\n\u003cli\u003eThe particles are micronized to provide superior absorption. \u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"product-label-copy\"\u003e\n\u003ctable border=\"0\" cellpadding=\"0\" cellspacing=\"2\" width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003cth align=\"left\" colspan=\"3\" style=\"font-size: 11pt; font-weight: bold;\"\u003eSupplement Facts\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd colspan=\"3\" class=\"smalltext\"\u003eServing Size: 1 Scoop\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd colspan=\"3\" class=\"smalltext\"\u003eServings Per Container: 30\u003cbr\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd colspan=\"2\" class=\"smalltext\" style=\"font-weight: bold;\"\u003eAmount Per Serving\u003c\/td\u003e\n\u003ctd align=\"right\" style=\"white-space: nowrap;\" class=\"smalltext\"\u003e\u003cstrong\u003e%DV\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"smalltext\"\u003eVeri-te® Pure \u003cem\u003eTrans\u003c\/em\u003e-Resveratrol\u003c\/td\u003e\n\u003ctd align=\"right\" class=\"smalltext\" style=\"white-space: nowrap;\"\u003e1000 mg\u003c\/td\u003e\n\u003ctd align=\"right\" class=\"smalltext\" style=\"white-space: nowrap;\"\u003e†\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd colspan=\"3\" class=\"smalltext\"\u003e† Daily Value (DV) not established\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\nREV.01.25 \u003cbr\u003e\u003cbr\u003eVeri-te® is a registered trademark of the Lallemand group.\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eSUGGESTED DAILY USE: \u003c\/strong\u003eTake one (1) scoop daily with food, or as directed by your\u003cbr\u003ehealthcare professional.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNOTE:\u003c\/strong\u003e Store in a cool, dry place. Protect from light, heat and humidity. Do not use if tamper-evident packaging is broken. Package filled by weight, not volume.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAUTION:\u003c\/strong\u003e For use by healthy adults only. Please consult your physician before use if you are pregnant or nursing, under the age of 18, or are undergoing treatment for a medical condition. Do not exceed the suggested use. \u003cstrong\u003eKEEP OUT OF REACH OF CHILDREN.\u003c\/strong\u003e Store in a cool and dry place after opening.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cem\u003eThis product is sold by weight, not volume. Contents may settle during shipping and handling. Each leveled scoop contains approximately 1,000 mg. A milligram scale is recommended for an exact dose.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"summary-copy\"\u003e\n\u003cp\u003e\u003cstrong\u003eBest Form of Resveratrol.\u003c\/strong\u003e Other resveratrol supplements are typically composed of 50% trans-resveratrol and 50% cis-resveratrol. ProHealth uses trans-resveratrol because it has a higher biological availability.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSuperior Absorption.\u003c\/strong\u003e The particles are micronized to provide superior absorption and the 100 gram container is perfect for people wanting to buy in bulk.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eNatural Source.\u003c\/strong\u003e ProHealth’s trans-resveratrol is pure and natural for the highest quality.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eHigher Dose.\u003c\/strong\u003e Each serving contains 1000 mg pure and natural trans-resveratrol.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eQuality Manufacturing Practices.\u003c\/strong\u003e All of our products are manufactured in an FDA-registered, GMP-certified facility.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eThird-Party Tested in the USA.\u003c\/strong\u003e Every batch is third-party tested in US laboratories to ensure the highest quality, purity and potency. Certificates of Analysis are available.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eAdditional Certifications.\u003c\/strong\u003e Non-GMO, Vegan and Gluten-Free\u003c\/p\u003e\n\u003c\/div\u003e","brand":"ProHealth Wholesale","offers":[{"title":"Default Title","offer_id":42864174858400,"sku":"PH576","price":35.1,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0507\/7588\/3936\/files\/PH576_FRNT_120ML_Jar-600x600_REV1026.png?v=1791991774"},{"product_id":"prohealth-nmn-pro-complete-1000-mg-75-grams-ph578","title":"NMN Pro™ Complete - Uthever® NMN, Trans-Resveratrol, TMG - 75 grams","description":"\u003cdiv class=\"product-benefits-copy\"\u003e\n\u003ch2\u003eHelps combat aging, improves heart health and promotes muscle strength\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eNMN supplementation has been found to improve various parameters of health, including physical endurance and muscle strength, neurological function, heart health, body weight and gene expression.\u003c\/li\u003e\n\u003cli\u003eNicotinamide mononucleotide (NMN) is a derivative of the B-vitamin niacin that dramatically improves health and longevity by serving as a precursor to NAD+.\u003c\/li\u003e\n\u003cli\u003eTrans-Resveratrol boosts the effectiveness of NMN, supports healthy aging, and promotes a balanced immune response.\u003c\/li\u003e\n\u003cli\u003eTMG is a methyl donor that complements NMN supplementation by helping replenish the body's methyl pool.\u003c\/li\u003e\n\u003cli\u003eNMN Pro Complete is the first and only perfectly balanced combination of NMN, Trans-Resveratrol and TMG on the market. Instead of having to take three separate supplements each day, you can now get the ideal balance of all three in one convenient serving.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cspan style=\"color: #0000ff;\"\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0507\/7588\/3936\/files\/PH578-COA-2025-12-16_Shopify.jpg?v=1767825863\" rel=\"noopener noreferrer\" style=\"color: #0000ff;\" target=\"_blank\"\u003eView Certificate of Analysis \u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cbr\u003e\n\u003ch3\u003eResearch Supported Benefits:\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003e Supports Longevity.\u003c\/strong\u003e Studies have shown that boosting NAD+ synthesis in the body extends the lifespan of yeast, worms and flies. (1)\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eProtects Heart and Muscle Health.\u003c\/strong\u003e Studies have shown that the combination of NMN and resveratrol is uniquely able to increase NAD+ concentrations even more than NMN alone. In heart tissue, NAD+ concentrations were shown to be 1.6 times greater, and in skeletal muscle, NAD+ concentrations were 1.7 times greater than when supplementing only with NMN. (13)\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e Blood Sugar Regulation.\u003c\/strong\u003e As we age, we have more trouble processing glucose, leading to higher blood sugar. Supplemental NMN is shown to improve several markers of skeletal muscle glucose metabolism that are commonly dysregulated in people with metabolic disorders. (2)\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e Supports Metabolism and Healthy Weight.\u003c\/strong\u003e Although excessive body weight can develop at any age, adults over age 40 are particularly susceptible to age-related weight gain as metabolism slows down and body composition is altered to favor fat over lean muscle. As obese individuals have reductions in both NAD+ levels and ATP (energy) production, replenishing NAD+ through NMN can help to reverse this while improving metabolic pathways to maintain a healthy weight. (3,4,5)\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e Supports Healthy Cognition:\u003c\/strong\u003e Declining cognitive function with age is related to a reduced NAD+ levels that impair mitochondrial function. Replenishing NAD+ stores through NMN may be able to prevent this dysfunction. (6,7)\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e Supports Healthy Skin:\u003c\/strong\u003e In our 30s and 40s, the appearance of our skin can start to show signs of age. Several studies have examined how boosting NAD+ levels in the skin prevents premature skin aging or supports a healthier external appearance. (8,9)\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eReferences:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e1. Fang EF, Kassahun H, Croteau DL, et al. NAD+ Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair. Cell Metab. 2016;24(4):566-581. doi:10.1016\/j.cmet.2016.09.004 \u003cbr\u003e\u003cbr\u003e2. Feng Z, Qin Y, Huo F, et al. NMN recruits GSH to enhance GPX4-mediated ferroptosis defense in UV irradiation induced skin injury. Biochim Biophys Acta Mol Basis Dis. 2022;1868(1):166287. doi:10.1016\/j.bbadis.2021.166287 \u003cbr\u003e\u003cbr\u003e3. Gopi S, Balakrishnan P. Evaluation and clinical comparison studies on liposomal and non-liposomal ascorbic acid (vitamin C) and their enhanced bioavailability. J Liposome Res. 2021;31(4):356-364. doi:10.1080\/08982104.2020.1820521 \u003cbr\u003e\u003cbr\u003e4. Katayoshi T, Nakajo T, Tsuji-Naito K. Restoring NAD+ by NAMPT is essential for the SIRT1\/p53-mediated survival of UVA- and UVB-irradiated epidermal keratinocytes. J Photochem Photobiol B. 2021;221:112238. doi:10.1016\/j.jphotobiol.2021.112238 \u003cbr\u003e\u003cbr\u003e5. Kim M, Seol J, Sato T, Fukamizu Y, Sakurai T, Okura T. Effect of 12-Week Intake of Nicotinamide Mononucleotide on Sleep Quality, Fatigue, and Physical Performance in Older Japanese Adults: A Randomized, Double-Blind Placebo-Controlled Study. Nutrients. 2022;14(4):755. Published 2022 Feb 11. doi:10.3390\/nu14040755 \u003cbr\u003e\u003cbr\u003e6. Kiss T, Nyúl-Tóth Á, Balasubramanian P, et al. Nicotinamide mononucleotide (NMN) supplementation promotes neurovascular rejuvenation in aged mice: transcriptional footprint of SIRT1 activation, mitochondrial protection, anti-inflammatory, and anti-apoptotic effects. Geroscience. 2020;42(2):527-546. doi:10.1007\/s11357-020-00165-5 \u003cbr\u003e\u003cbr\u003e7. Liao B, Zhao Y, Wang D, Zhang X, Hao X, Hu M. Nicotinamide mononucleotide supplementation enhances aerobic capacity in amateur runners: a randomized, double-blind study. J Int Soc Sports Nutr. 2021;18(1):54. Published 2021 Jul 8. doi:10.1186\/s12970-021-00442- \u003cbr\u003e\u003cbr\u003e8. Mills KF, Yoshida S, Stein LR, et al. Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice. Cell Metab. 2016;24(6):795-806. doi:10.1016\/j.cmet.2016.09.013 \u003cbr\u003e\u003cbr\u003e9. Tarantini S, Valcarcel-Ares MN, Toth P, et al. Nicotinamide mononucleotide (NMN) supplementation rescues cerebromicrovascular endothelial function and neurovascular coupling responses and improves cognitive function in aged mice. Redox Biol. 2019;24:101192. doi:10.1016\/j.redox.2019.101192 \u003cbr\u003e\u003cbr\u003e10. Wang X, Hu X, Yang Y, Takata T, Sakurai T. Nicotinamide mononucleotide protects against β-amyloid oligomer-induced cognitive impairment and neuronal death. Brain Res. 2016;1643:1-9. doi:10.1016\/j.brainres.2016.04.060 \u003cbr\u003e\u003cbr\u003e11. Yoshino J, Mills KF, Yoon MJ, Imai S. Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice. Cell Metab. 2011;14(4):528-536. doi:10.1016\/j.cmet.2011.08.014 \u003cbr\u003e\u003cbr\u003e12. Yoshino M, Yoshino J, Kayser BD, et al. Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women. Science. 2021;372(6547):1224-1229. doi:10.1126\/science.abe9985 \u003cbr\u003e\u003cbr\u003e13. Bai L, Yau L, Tong T, Chan W, Zhang W, Jiang Z. Improvement of tissue‐specific distribution and biotransformation potential of nicotinamide mononucleotide in combination with ginsenosides or resveratrol. Pharmacol Res Perspect. 2022;10(4):e00986. doi:10.1002\/prp2.986\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"product-how-it-work-copy\"\u003e\n\u003cul\u003e\n\u003cli\u003eNicotinamide mononucleotide (NMN) is a derivative of the B-vitamin niacin that dramatically improves health and longevity by serving as a precursor to NAD+, a compound that plays a crucial role in energy production, metabolism and gene expression in the body. When we boost NMN levels in the body, we can enhance the biosynthesis of NAD+ and alleviate symptoms associated with depletion of this crucial nutrient. NMN supplementation has been found to improve various parameters of health, including physical endurance and muscle strength, brain health, heart health, body weight and gene expression.\u003c\/li\u003e\n\u003cli\u003eNMN and trans-resveratrol work synergistically, which is why longevity experts recommend taking them together for the greatest effectiveness. This dynamic duo has been likened to the operation of a car, with NMN as the fuel and trans-resveratrol as the accelerator pedal.\u003c\/li\u003e\n\u003cli\u003eRegular resveratrol is composed of 50% trans-resveratrol and 50% cis-resveratrol. Because research suggests that only the trans-form has valuable biological activity, NMN Pro Complete contains pure, natural, pharmaceutical grade trans-resveratrol.\u003c\/li\u003e\n\u003cli\u003eTMG, also known as betaine anhydrous, is an amino acid that supports the body's methylation processes. These processes are known to decline with age and may also be affected by common gene mutations. Also, NMN supplementation may require the use of methyl groups to help facilitate the conversion of NAD+ in your cells, thereby activating sirtuin genes and promoting longevity.*\u003c\/li\u003e\n\u003cli\u003eMany top anti-aging experts suggest that safeguarding against methyl depletion may be a wise proactive step to augment your NMN intake. TMG, the choice of many of those experts, is an excellent way to help support your body's ability to maintain an adequate methyl pool.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"summary-copy\"\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eOnly Clincially-Proven NMN.\u003c\/strong\u003e ProHealth’s NMN is the only clinically-proven NMN to boost NAD+ levels in a peer-reviewed, double-blind, placebo-controlled, published, clinical study. Results of the study indicated a 38% increase in NAD+ levels and 12-year reversal in biological age.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eUnique Formula.\u003c\/strong\u003e NMN Pro Complete is the first and only perfectly balanced combination of NMN, Trans-Resveratrol and TMG on the market. Instead of having to take three separate supplements each day, you can now get the ideal balance of all three in one convenient serving. A single scoop of NMN Pro Complete will provide you with 1,000 mg of NMN, 1,000 mg of trans-resveratrol, and 500 mg of TMG – the daily dosage most often recommended by the world's leading longevity experts.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMicronized.\u003c\/strong\u003e Micronized for superior absorption and bioavailability.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSolvent-Free.\u003c\/strong\u003e Compared to other NMN products, ours is made without any chemical solvents.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eQuality Manufacturing Practices.\u003c\/strong\u003e All of our products are manufactured in an FDA-registered, GMP-certified facility.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eThird-Party Tested in the USA.\u003c\/strong\u003e Every batch is third-party tested in US laboratories to ensure the highest quality, purity and potency. Certificates of Analysis are available.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cstrong\u003eBe Aware of Fake NMN:\u003c\/strong\u003e Fraudulent companies are always attempting to out-price competitors by using NMN fake ingredients to gain market share, which is not fair to you, the consumer, or the reputable companies, like ProHealth that spends time and resources to ensure a safe and pure NMN product.\u003c\/div\u003e\n\u003cdiv class=\"product-label-copy\"\u003e\n\u003ctable width=\"100%\" cellspacing=\"2\" cellpadding=\"0\" border=\"0\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003cth style=\"font-size: 11pt; font-weight: bold;\" colspan=\"3\" align=\"left\"\u003eSupplement Facts\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"smalltext\" colspan=\"3\"\u003eServing Size: 1 Scoop (2.5 g)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"smalltext\" colspan=\"3\"\u003eServings Per Container: 30\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"font-weight: bold;\" class=\"smalltext\" colspan=\"2\"\u003eAmount Per Serving\u003c\/td\u003e\n\u003ctd class=\"smalltext\" style=\"white-space: nowrap;\" align=\"right\"\u003e\u003cstrong\u003e%DV\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"smalltext\"\u003eUthever® β-Nicotinamide Mononucleotide (NMN)\u003cbr\u003e\n\u003c\/td\u003e\n\u003ctd style=\"white-space: nowrap;\" class=\"smalltext\" align=\"right\"\u003e1000 mg\u003c\/td\u003e\n\u003ctd style=\"white-space: nowrap;\" class=\"smalltext\" align=\"right\"\u003e†\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"smalltext\"\u003eVeri-te® Trans-Resveratrol\u003c\/td\u003e\n\u003ctd style=\"white-space: nowrap;\" class=\"smalltext\" align=\"right\"\u003e1000 mg\u003c\/td\u003e\n\u003ctd style=\"white-space: nowrap;\" class=\"smalltext\" align=\"right\"\u003e†\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"smalltext\"\u003eTrimethylglycine (TMG)\u003c\/td\u003e\n\u003ctd style=\"white-space: nowrap;\" class=\"smalltext\" align=\"right\"\u003e500 mg\u003c\/td\u003e\n\u003ctd style=\"white-space: nowrap;\" class=\"smalltext\" align=\"right\"\u003e†\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"smalltext\" colspan=\"3\"\u003e† Daily Value (DV) not established\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\nREV.09.25\u003cbr\u003e\u003cbr\u003eUthever® is a registered trademark of Effepharm (Shanghai) Co., Ltd. Veri-te® is a registered *These statements have not been evaluated by the Food trademark of the Lallemand group.\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eOTHER INGREDIENTS: \u003c\/strong\u003eNone.\u003cstrong\u003e\u003c\/strong\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSUGGESTED DAILY USE:\u003c\/strong\u003e Add one (1) scoop to 8-12 oz of liquid per day, mix thoroughly and drink, preferably in the morning.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAUTION:\u003c\/strong\u003e Please consult your physician before use if you are pregnant or nursing, under the age of 18, or are undergoing treatment for a medical condition. Do not exceed the suggested use. \u003cstrong\u003eKEEP OUT OF REACH OF CHILDREN\u003c\/strong\u003e. Store in a cool and dry place.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e","brand":"ProHealth Wholesale","offers":[{"title":"Default Title","offer_id":42864416981152,"sku":"PH578","price":82.95,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0507\/7588\/3936\/files\/PH578_FRNT_250ML_Jar_600x600_REV0925.png?v=1775506129"},{"product_id":"prohealth-longevity-fisetin-pro-longevity-60-capsules-ph590","title":"Fisetin Pro Longevity - 60 capsules","description":"\u003cdiv class=\"product-benefits-copy\"\u003e\n\u003ch2\u003eSupport and Maintain Healthy Brain Function\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eSupports longevity\u003c\/li\u003e\n\u003cli\u003ePromotes brain health\u003c\/li\u003e\n\u003cli\u003eEnhances cellular health\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cspan style=\"color: #0000ff;\"\u003e\u003ca style=\"color: #0000ff;\" href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0507\/7588\/3936\/files\/PH590_-_COA_Brighton_LOT_26038_2025-12-01-1_2.pdf?v=1765471227\" target=\"_blank\"\u003eView Certificate of Analysis »\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003ch3\u003eResearch-Supported Benefits:\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eSupports Longevity\u003c\/strong\u003e. Fisetin supports longevity by aiding in the removal of senescent cells from the body. (1) Senescent cells, also known as zombie cells, accumulate as we age and contribute to oxidative stress, inflammation and accelerated cellular aging. Research shows that removing senescent cells extends lifespan in animals. (1)\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePromotes Brain Health\u003c\/strong\u003e. Research shows that fisetin supplementation may reduce symptoms of age-related brain health decline. (2) Functioning as an antioxidant to reduce neuroinflammation, fisetin has been shown to enhance learning and memory. (2) Additionally, fisetin may prevent brain cell death associated with brain aging. (2)\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eEnhances Cellular Health\u003c\/strong\u003e. Oxidative stress contributes to cellular damage and accelerated cellular aging. While inflammation and oxidative stress are natural, high levels of oxidative stress and inflammation dramatically reduce longevity. Research shows that fisetin supplementation may reduce oxidative stress and inflammation due to its antioxidant effects, thus promoting longevity. (3)\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eReferences:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e1. Yousefzadeh MJ, Zhu Y, McGowan SJ, et al. Fisetin is a senotherapeutic that extends health and lifespan. EBioMedicine. 2018;36:18-28. doi:10.1016\/j.ebiom.2018.09.015 \u003cbr\u003e\u003cbr\u003e2. Nabavi SF, Braidy N, Habtemariam S, Sureda A, Manayi A, Nabavi SM. Neuroprotective Effects of Fisetin in Alzheimer's and Parkinson's Diseases: From Chemistry to Medicine. Curr Top Med Chem. 2016;16(17):1910-1915. doi:10.2174\/1568026616666160204121725 \u003cbr\u003e\u003cbr\u003e3. Jiang K, Yang J, Xue G, Dai A, Wu H. Fisetin Ameliorates the Inflammation and Oxidative Stress in Lipopolysaccharide-Induced Endometritis. J Inflamm Res. 2021;14:2963-2978. Published 2021 Jul 5. doi:10.2147\/JIR.S314130\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"product-label-copy\"\u003e\n\u003ctable width=\"100%\" cellspacing=\"2\" cellpadding=\"0\" border=\"0\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003cth colspan=\"3\" style=\"font-size: 11pt; font-weight: bold;\" align=\"left\"\u003eSupplement Facts\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd colspan=\"3\" class=\"smalltext\"\u003eServing Size: 1 Capsule\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd colspan=\"3\" class=\"smalltext\"\u003eServings Per Container: 60\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd colspan=\"2\" class=\"smalltext\" style=\"font-weight: bold;\"\u003eAmount Per Serving\u003c\/td\u003e\n\u003ctd class=\"smalltext\" style=\"white-space: nowrap;\" align=\"right\"\u003e\u003cstrong\u003e%DV\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"smalltext\"\u003e\n\u003cstrong\u003eProprietary Lifespan Absorption Blend™\u003c\/strong\u003e \u003cbr\u003e  Glucomannan (from Konjac Root), Marshmallow Root Powder, Green\u003cbr\u003e  Tea Leaf Extract (45% EGCG), Long Pepper Fruit Extract (20:1), Quercetin\u003cbr\u003e  (from \u003cem\u003eSophora japonica\u003c\/em\u003e Flower Extract), Turmeric Root Extract (95% Curcuminoids)s \u003cbr\u003e\n\u003c\/td\u003e\n\u003ctd class=\"smalltext\" style=\"white-space: nowrap;\" align=\"right\"\u003e350 mg\u003c\/td\u003e\n\u003ctd class=\"smalltext\" style=\"white-space: nowrap;\" align=\"right\"\u003e†\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"smalltext\"\u003eFisetin (from \u003cem\u003eRhus succedanea\u003c\/em\u003e \u003cbr\u003e  Stem Extract)\u003c\/td\u003e\n\u003ctd class=\"smalltext\" style=\"white-space: nowrap;\" align=\"right\"\u003e125 mg\u003c\/td\u003e\n\u003ctd class=\"smalltext\" style=\"white-space: nowrap;\" align=\"right\"\u003e†\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"smalltext\"\u003eMedium-Chain Triglycerides (MCT) Oil\u003cbr\u003e  Powder (from Coconut)\u003c\/td\u003e\n\u003ctd class=\"smalltext\" style=\"white-space: nowrap;\" align=\"right\"\u003e25 mg\u003c\/td\u003e\n\u003ctd class=\"smalltext\" style=\"white-space: nowrap;\" align=\"right\"\u003e†\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd colspan=\"3\" class=\"smalltext\"\u003e† Daily Value (DV) not established\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\nREV.07.25\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eOTHER INGREDIENTS:\u003c\/strong\u003e Vegetable cellulose (capsule), brown rice flour. \u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSUGGESTED DAILY USE:\u003c\/strong\u003e Take on (1) or two (2) capsules per day. \u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAUTION:\u003c\/strong\u003e For use by healthy adults only. Please consult your physician before use if you are pregnant or nursing, under the age of 18, or are undergoing treatment for a medical condition. Do not exceed the suggested use. \u003cstrong\u003eKEEP OUT OF REACH OF CHILDREN\u003c\/strong\u003e. Store in a cool and dry place after opening.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"product-how-it-work-copy\"\u003e\n\u003cul\u003e\n\u003cli\u003eFisetin is one of the most potent senolytic compounds in existence. Senolytics are defined as nutrients that aid in the removal of senescent cells from the body. As senescent cells accumulate, oxidative stress and longevity decrease.\u003c\/li\u003e\n\u003cli\u003eDNA damage accelerates cellular aging. Fisetin may protect against DNA damage and promote DNA repair.\u003c\/li\u003e\n\u003cli\u003eFisetin exhibits powerful antioxidant effects, reducing oxidative stress and inflammation.\u003c\/li\u003e\n\u003cli\u003eAs we age, our brain cells degrade due to oxidative stress—the buildup of inflammatory compounds called reactive oxygen species. As an antioxidant, fisetin fights off oxidative stress that damages our cells, including neurons. Fisetin also has exhibited beneficial effects on age-related changes in the brain by triggering signaling pathways that promote brain cell growth and neuronal integrity.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"summary-copy\"\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eUnique Formulation.\u003c\/strong\u003e The majority of fisetin products have poor absorption. To help, we added a Proprietary Lifespan Absorption Blend™ to dramatically enhance bioavailability and efficacy and support various aspects of health.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eIncreased Absorption.\u003c\/strong\u003e To further enhance absorption, we included MCT Oil Powder. Adding a fat to the product helps increases the body’s ability to utilize fisetin.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSupported for Daily Use.\u003c\/strong\u003e Compared to other fisetin products that are intended to be used 1-2 times per week, our formula is safe enough to be used daily.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eQuality Manufacturing Practices.\u003c\/strong\u003e All of our products are manufactured in an FDA-registered, GMP-certified facility.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eThird-Party Tested in the USA.\u003c\/strong\u003e Every batch is third-party tested in US laboratories to ensure the highest quality, purity and potency. Certificates of Analysis are available.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e","brand":"ProHealth Wholesale","offers":[{"title":"Default Title","offer_id":45096779546784,"sku":"PH590","price":37.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0507\/7588\/3936\/files\/PH590_FRNT_250CC-600x600-REV0725.png?v=1788991462"},{"product_id":"prohealth-bulk-trans-resveratrol-500-grams-ph573","title":"Pure Trans-Resveratrol Powder - 500 grams","description":"\u003cdiv class=\"product-benefits-copy\"\u003e\n\u003ch2\u003eSupports brain, cardiovascular, cellular and joint health\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eSupports brain health and cognitive function\u003c\/li\u003e\n\u003cli\u003eSupports cellular and DNA health\u003c\/li\u003e\n\u003cli\u003eSupports healthy aging\u003c\/li\u003e\n\u003cli\u003eSupports heart and metabolic health\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cspan style=\"color: #0000ff;\"\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0507\/7588\/3936\/files\/PH573_-_COA_Brighton_LOT_25339_2025.03.12_2.pdf?v=1742423811\" style=\"color: #0000ff;\" target=\"_blank\"\u003eView Certificate of Analysis »\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003ch3\u003eResearch-Supported Benefits:\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eSupports Brain Health\u003c\/strong\u003e. Research shows that resveratrol, a molecule found in red grapes and wine, may protect the brain from symptoms of brain aging, including improving memory and delaying cognitive decline. The neuroprotective effects of resveratrol come from its sirtuin-activating, inflammation-regulating, mitochondrial-supporting and antioxidant activity. (1-3)\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSupports Cellular and DNA Health\u003c\/strong\u003e. Resveratrol acts as a potent antioxidant, which reduces harmful oxidative stress. It also activates genes called sirtuins. Healthy sirtuin activity helps to fight cellular senescence, support DNA repair, boost mitochondrial function and generate cellular energy through ATP production. (3,4)\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSupports Healthy Aging\u003c\/strong\u003e. Resveratrol activates SIRT1, often referred to as the \"longevity gene.\" Healthy older adults tend to have higher levels of SIRT1 activity, and SIRT1 overexpression can increase lifespan in worms and animals. In humans, SIRT1 supports healthy aging and longevity. (5,6)\u003c\/p\u003e\n\u003cp\u003eSupports Joint Health. Due to its role in supporting healthier inflammatory responses and modulating oxidative stress, resveratrol has exhibited joint-protective effects. (7)\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSupports Heart Health\u003c\/strong\u003e. Resveratrol is well-known for its link to supporting cardiovascular health. Research has found that resveratrol benefits endothelial function, blood vessel health and blood pressure by boosting SIRT1 activity, reducing oxidative stress and increasing nitric oxide production. (8,9)\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSupports Metabolic Health\u003c\/strong\u003e. Resveratrol activates SIRT1, which has been studied for its role in supporting healthier glucose metabolism. People with reduced SIRT1 expression tend to have higher blood sugar, poor glucose control and metabolic disorders. (10)\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eReferences:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e1. Salehi B, Mishra AP, Nigam M, et al. Resveratrol: A Double-Edged Sword in Health Benefits. Biomedicines. 2018;6(3):91. Published 2018 Sep 9. \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6164842\/\" target=\"_blank\"\u003edoi:10.3390\/biomedicines6030091\u003c\/a\u003e \u003cbr\u003e\u003cbr\u003e2. Bastianetto S, Ménard C, Quirion R. Neuroprotective action of resveratrol. Biochim Biophys Acta. 2015;1852(6):1195-1201. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25281824\/\"\u003edoi:10.1016\/j.bbadis.2014.09.011\u003c\/a\u003e \u003cbr\u003e\u003cbr\u003e3. Moraes DS, Moreira DC, Andrade JMO, Santos SHS. Sirtuins, brain and cognition: A review of resveratrol effects. IBRO Rep. 2020;9:46-51. Published 2020 Jun 26. \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7733131\/?report=reader\"\u003edoi:10.1016\/j.ibror.2020.06.004\u003c\/a\u003e\u003cspan data-contrast=\"auto\" style=\"font-size: 11pt; line-height: 21.85px; font-family: Calibri, 'Calibri_EmbeddedFont', 'Calibri_MSFontService', sans-serif;\" class=\"TextRun SCXW41998961 BCX2\" lang=\"EN\"\u003e\u003cspan class=\"NormalTextRun SCXW41998961 BCX2\"\u003e\u003c\/span\u003e\u003c\/span\u003e \u003cbr\u003e\u003cbr\u003e4. Borra MT, Smith BC, Denu JM. Mechanism of human SIRT1 activation by resveratrol. J Biol Chem. 2005;280(17):17187-17195. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/15749705\/\"\u003edoi:10.1074\/jbc.M501250200 \u003c\/a\u003e\u003cbr\u003e\u003cbr\u003e5. Kilic U, Gok O, Erenberk U, et al. A remarkable age-related increase in SIRT1 protein expression against oxidative stress in elderly: SIRT1 gene variants and longevity in human. PLoS One. 2015;10(3):e0117954. Published 2015 Mar 18. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/15749705\/\"\u003edoi:10.1371\/journal.pone.0117954\u003c\/a\u003e \u003cbr\u003e\u003cbr\u003e6. Salminen A, Kaarniranta K. SIRT1: regulation of longevity via autophagy. Cell Signal. 2009;21(9):1356-1360. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/19249351\/\"\u003edoi:10.1016\/j.cellsig.2009.02.014 \u003c\/a\u003e\u003cbr\u003e\u003cbr\u003e7. Nguyen C, Savouret JF, Widerak M, Corvol MT, Rannou F. Resveratrol, Potential Therapeutic Interest in Joint Disorders: A Critical Narrative Review. Nutrients. 2017;9(1):45. Published 2017 Jan 6. \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5295089\/?report=classic\"\u003edoi:10.3390\/nu9010045\u003c\/a\u003e \u003cbr\u003e\u003cbr\u003e8. Marques BCAA, Trindade M, Aquino JCF, et al. Beneficial effects of acute trans-resveratrol supplementation in treated hypertensive patients with endothelial dysfunction. Clin Exp Hypertens. 2018;40(3):218-223. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29431520\/\"\u003edoi:10.1080\/10641963.2017.128874\u003c\/a\u003e1 \u003cbr\u003e\u003cbr\u003e9. Bonnefont-Rousselot D. Resveratrol and Cardiovascular Diseases. Nutrients. 2016;8(5):250. Published 2016 May 2. \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4882663\/\"\u003edoi:10.3390\/nu8050250\u003c\/a\u003e \u003cbr\u003e\u003cbr\u003e10. Hou CY, Tain YL, Yu HR, Huang LT. The Effects of Resveratrol in the Treatment of Metabolic Syndrome. Int J Mol Sci. 2019;20(3):535. Published 2019 Jan 28. \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6387422\/\"\u003edoi:10.3390\/ijms20030535 \u003c\/a\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"summary-copy\"\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eBest Form of Resveratrol.\u003c\/strong\u003e Other resveratrol supplements are typically composed of 50% trans-resveratrol and 50% cis-resveratrol. ProHealth uses trans-resveratrol because it has a higher biological availability.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSuperior Absorption.\u003c\/strong\u003e The particles are micronized to provide superior absorption and the 500 gram container is perfect for people wanting to buy in bulk.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNatural Source.\u003c\/strong\u003e ProHealth’s trans-resveratrol is pure and natural for the highest quality.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHigher Dose.\u003c\/strong\u003e Each serving contains 1000 mg pure and natural trans-resveratrol.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eQuality Manufacturing Practices.\u003c\/strong\u003e All of our products are manufactured in an FDA-registered, GMP-certified facility.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eThird-Party Tested in the USA.\u003c\/strong\u003e Every batch is third-party tested in US laboratories to ensure the highest quality, purity and potency. Certificates of Analysis are available.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAdditional Certifications.\u003c\/strong\u003e Non-GMO, Vegan and Gluten-Free\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"product-label-copy\"\u003e\n\u003ctable width=\"100%\" cellspacing=\"2\" cellpadding=\"0\" border=\"0\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003cth style=\"font-size: 11pt; font-weight: bold;\" colspan=\"3\" align=\"left\"\u003eSupplement Facts\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"smalltext\" colspan=\"3\"\u003eServing Size: 1 Scoop\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"smalltext\" colspan=\"3\"\u003eServings Per Container: 500\u003cbr\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"font-weight: bold;\" class=\"smalltext\" colspan=\"2\"\u003eAmount Per Serving\u003c\/td\u003e\n\u003ctd class=\"smalltext\" style=\"white-space: nowrap;\" align=\"right\"\u003e\u003cstrong\u003e%DV\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"smalltext\"\u003eVeri-te® Pure \u003cem\u003eTrans\u003c\/em\u003e-Resveratrol\u003cbr\u003e\n\u003c\/td\u003e\n\u003ctd style=\"white-space: nowrap;\" class=\"smalltext\" align=\"right\"\u003e1000 mg\u003c\/td\u003e\n\u003ctd style=\"white-space: nowrap;\" class=\"smalltext\" align=\"right\"\u003e†\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"smalltext\" colspan=\"3\"\u003e† Daily Value not established\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\nREV. 01.25 \u003cbr\u003e\u003cbr\u003e** Herbal products such as this are likely to have minor color variation from batch to batch because of the geographical and seasonal variations of the raw material.\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eSUGGESTED DAILY USE:\u003c\/strong\u003e Take one (1) scoop daily with food, or as recommended by your healthcare professional.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAUTION:\u003c\/strong\u003e For use by healthy adults only. Please consult your physician before use if you are pregnant or nursing, under the age of 18, or are undergoing treatment for a medical condition. Do not exceed the suggested use. \u003cstrong\u003eKEEP OUT OF REACH OF CHILDREN\u003c\/strong\u003e. Store in a cool and dry place after opening.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003cp\u003e\u003cem\u003eThis product is sold by weight, not volume. Contents may settle during shipping and handling. Each leveled scoop contains approximately 1,000 mg. A milligram scale is recommended for an exact dose.\u003c\/em\u003e\u003c\/p\u003e\n\u003cdiv class=\"product-how-it-work-copy\"\u003e\n\u003cul\u003e\n\u003cli\u003eResveratrol is a naturally occurring polyphenol that works by activating longevity genes called sirtuins, acting as an antioxidant, regulating inflammatory responses and supporting mitochondrial health.\u003c\/li\u003e\n\u003cli\u003eTrans-resveratrol is the most bioavailable form of resveratrol.\u003c\/li\u003e\n\u003cli\u003eProHealth's Micronized Trans-Resveratrol powder delivers 1000 mg of pharmaceutical grade, 98% pure, natural trans-resveratrol per serving.\u003c\/li\u003e\n\u003cli\u003eThe particles are micronized to provide superior absorption.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e","brand":"ProHealth Wholesale","offers":[{"title":"Default Title","offer_id":45096790294688,"sku":"PH573","price":343.24,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0507\/7588\/3936\/files\/PH573_FRNT_8.5x11_Bag-600x600-REV0125.png?v=1791993643"},{"product_id":"prohealth-bulk-micronized-trans-resveratrol-250-grams-ph572","title":"Pure Trans-Resveratrol Powder - 250 grams","description":"\u003cdiv class=\"product-benefits-copy\"\u003e\n\u003ch2\u003eSupports brain, cardiovascular, cellular and joint health\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eSupports brain health and cognitive function\u003c\/li\u003e\n\u003cli\u003eSupports cellular and DNA health\u003c\/li\u003e\n\u003cli\u003eSupports healthy aging\u003c\/li\u003e\n\u003cli\u003eSupports heart and metabolic health\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cspan style=\"color: #0000ff;\"\u003e\u003ca style=\"color: #0000ff;\" rel=\"noopener noreferrer\" href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0507\/7588\/3936\/files\/PH572_-_COA_Brighton_LOT_26090_2025-10-15.pdf?v=1761155625\" target=\"_blank\"\u003eView Certificate of Analysis \u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003ch3\u003eResearch-Supported Benefits:\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eSupports Brain Health\u003c\/strong\u003e. Research shows that resveratrol, a molecule found in red grapes and wine, may protect the brain from symptoms of brain aging, including improving memory and delaying cognitive decline. The neuroprotective effects of resveratrol come from its sirtuin-activating, inflammation-regulating, mitochondrial-supporting and antioxidant activity. (1-3)\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSupports Cellular and DNA Health\u003c\/strong\u003e. Resveratrol acts as a potent antioxidant, which reduces harmful oxidative stress. It also activates genes called sirtuins. Healthy sirtuin activity helps to fight cellular senescence, support DNA repair, boost mitochondrial function and generate cellular energy through ATP production. (3,4)\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSupports Healthy Aging\u003c\/strong\u003e. Resveratrol activates SIRT1, often referred to as the \"longevity gene.\" Healthy older adults tend to have higher levels of SIRT1 activity, and SIRT1 overexpression can increase lifespan in worms and animals. In humans, SIRT1 supports healthy aging and longevity. (5,6)\u003c\/p\u003e\n\u003cp\u003eSupports Joint Health. Due to its role in supporting healthier inflammatory responses and modulating oxidative stress, resveratrol has exhibited joint-protective effects. (7)\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSupports Heart Health\u003c\/strong\u003e. Resveratrol is well-known for its link to supporting cardiovascular health. Research has found that resveratrol benefits endothelial function, blood vessel health and blood pressure by boosting SIRT1 activity, reducing oxidative stress and increasing nitric oxide production. (8,9)\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSupports Metabolic Health\u003c\/strong\u003e. Resveratrol activates SIRT1, which has been studied for its role in supporting healthier glucose metabolism. People with reduced SIRT1 expression tend to have higher blood sugar, poor glucose control and metabolic disorders. (10)\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eReferences:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e1. Salehi B, Mishra AP, Nigam M, et al. Resveratrol: A Double-Edged Sword in Health Benefits. Biomedicines. 2018;6(3):91. Published 2018 Sep 9. \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6164842\/\" target=\"_blank\"\u003edoi:10.3390\/biomedicines6030091\u003c\/a\u003e \u003cbr\u003e\u003cbr\u003e2. Bastianetto S, Ménard C, Quirion R. Neuroprotective action of resveratrol. Biochim Biophys Acta. 2015;1852(6):1195-1201. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25281824\/\"\u003edoi:10.1016\/j.bbadis.2014.09.011\u003c\/a\u003e \u003cbr\u003e\u003cbr\u003e3. Moraes DS, Moreira DC, Andrade JMO, Santos SHS. Sirtuins, brain and cognition: A review of resveratrol effects. IBRO Rep. 2020;9:46-51. Published 2020 Jun 26. \u003cspan class=\"TextRun SCXW41998961 BCX2\" style=\"font-size: 11pt; line-height: 21.85px; font-family: Calibri, 'Calibri_EmbeddedFont', 'Calibri_MSFontService', sans-serif;\" lang=\"EN\"\u003e\u003cspan class=\"NormalTextRun SCXW41998961 BCX2\"\u003e\u003c\/span\u003e\u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7733131\/?report=reader\" style=\"text-decoration: none; color: inherit;\" class=\"Hyperlink SCXW41998961 BCX2\" target=\"_blank\"\u003e\u003cspan class=\"TextRun Underlined SCXW41998961 BCX2\" style=\"color: #1155cc; font-size: 11pt; text-decoration: underline; line-height: 21.85px; font-family: Calibri, 'Calibri_EmbeddedFont', 'Calibri_MSFontService', sans-serif;\" lang=\"EN\"\u003e\u003cspan class=\"NormalTextRun SCXW41998961 BCX2\"\u003edoi:10.1016\/j.ibror.2020.06.004\u003c\/span\u003e\u003c\/span\u003e\u003c\/a\u003e \u003cbr\u003e\u003cbr\u003e4. Borra MT, Smith BC, Denu JM. Mechanism of human SIRT1 activation by resveratrol. J Biol Chem. 2005;280(17):17187-17195. doi:10.1074\/jbc.M501250200 \u003cbr\u003e\u003cbr\u003e5. Kilic U, Gok O, Erenberk U, et al. A remarkable age-related increase in SIRT1 protein expression against oxidative stress in elderly: SIRT1 gene variants and longevity in human. PLoS One. 2015;10(3):e0117954. Published 2015 Mar 18. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/15749705\/\"\u003edoi:10.1371\/journal.pone.0117954\u003c\/a\u003e \u003cbr\u003e\u003cbr\u003e6. Salminen A, Kaarniranta K. SIRT1: regulation of longevity via autophagy. Cell Signal. 2009;21(9):1356-1360. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/19249351\/\"\u003edoi:10.1016\/j.cellsig.2009.02.014 \u003c\/a\u003e\u003cbr\u003e\u003cbr\u003e7. Nguyen C, Savouret JF, Widerak M, Corvol MT, Rannou F. Resveratrol, Potential Therapeutic Interest in Joint Disorders: A Critical Narrative Review. Nutrients. 2017;9(1):45. Published 2017 Jan 6. \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5295089\/?report=classic\"\u003edoi:10.3390\/nu9010045\u003c\/a\u003e \u003cbr\u003e\u003cbr\u003e8. Marques BCAA, Trindade M, Aquino JCF, et al. Beneficial effects of acute trans-resveratrol supplementation in treated hypertensive patients with endothelial dysfunction. Clin Exp Hypertens. 2018;40(3):218-223. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29431520\/\"\u003edoi:10.1080\/10641963.2017.128874\u003c\/a\u003e1 \u003cbr\u003e\u003cbr\u003e9. Bonnefont-Rousselot D. Resveratrol and Cardiovascular Diseases. Nutrients. 2016;8(5):250. Published 2016 May 2. \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4882663\/\"\u003edoi:10.3390\/nu8050250\u003c\/a\u003e \u003cbr\u003e\u003cbr\u003e10. Hou CY, Tain YL, Yu HR, Huang LT. The Effects of Resveratrol in the Treatment of Metabolic Syndrome. Int J Mol Sci. 2019;20(3):535. Published 2019 Jan 28. \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6387422\/\"\u003edoi:10.3390\/ijms20030535 \u003c\/a\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"summary-copy\"\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eBest Form of Resveratrol.\u003c\/strong\u003e Other resveratrol supplements are typically composed of 50% trans-resveratrol and 50% cis-resveratrol. ProHealth uses trans-resveratrol because it has a higher biological availability.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSuperior Absorption.\u003c\/strong\u003e The particles are micronized to provide superior absorption and the 250 gram container is perfect for people wanting to buy in bulk.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNatural Source.\u003c\/strong\u003e ProHealth’s trans-resveratrol is pure and natural for the highest quality.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHigher Dose.\u003c\/strong\u003e Each serving contains 1000 mg pure and natural trans-resveratrol.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eQuality Manufacturing Practices.\u003c\/strong\u003e All of our products are manufactured in an FDA-registered, GMP-certified facility.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eThird-Party Tested in the USA.\u003c\/strong\u003e Every batch is third-party tested in US laboratories to ensure the highest quality, purity and potency. Certificates of Analysis are available.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAdditional Certifications.\u003c\/strong\u003e Non-GMO, Vegan and Gluten-Free\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"product-label-copy\"\u003e\n\u003ctable width=\"100%\" cellspacing=\"2\" cellpadding=\"0\" border=\"0\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003cth colspan=\"3\" style=\"font-size: 11pt; font-weight: bold;\" align=\"left\"\u003eSupplement Facts\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd colspan=\"3\" class=\"smalltext\"\u003eServing Size: 1 Scoop (1000 mg)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd colspan=\"3\" class=\"smalltext\"\u003eServings Per Container: 250\u003cbr\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd colspan=\"2\" class=\"smalltext\" style=\"font-weight: bold;\"\u003eAmount Per Serving\u003c\/td\u003e\n\u003ctd style=\"white-space: nowrap;\" class=\"smalltext\" align=\"right\"\u003e\u003cstrong\u003e%DV\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"smalltext\"\u003eVeri-te® Pure \u003cem\u003eTrans\u003c\/em\u003e-Resveratrol\u003c\/td\u003e\n\u003ctd class=\"smalltext\" style=\"white-space: nowrap;\" align=\"right\"\u003e1000 mg\u003c\/td\u003e\n\u003ctd class=\"smalltext\" style=\"white-space: nowrap;\" align=\"right\"\u003e†\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd colspan=\"3\" class=\"smalltext\"\u003e† Daily Value (DV) not established\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\nREV.01.25 \u003cbr\u003e\u003cbr\u003eVeri-te® is a registered trademark of the Lallemand group. \u003cbr\u003e\u003cbr\u003e** Herbal products such as this are likely to have minor color variation from batch to batch because of the geographical and seasonal variations of the raw material.\u003cbr\u003e\u003cbr\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eSUGGESTED DAILY USE:\u003c\/strong\u003e Take one (1) scoop daily with food, or as recommended by your healthcare professional.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAUTION:\u003c\/strong\u003e Not intended for use by pregnant or nursing women. Not formulated for use in children. If you have a medical condition or are taking medications, consult with your healthcare professional before using this product. KEEP OUT OF REACH OF CHILDREN.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cem\u003eThis product is sold by weight, not volume. Contents may settle during shipping and handling. Each leveled scoop contains approximately 1,000 mg. A milligram scale is recommended for an exact dose.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"product-how-it-work-copy\"\u003e\n\u003cul\u003e\n\u003cli\u003eResveratrol is a naturally occurring polyphenol that works by activating longevity genes called sirtuins, acting as an antioxidant, regulating inflammatory responses and supporting mitochondrial health.\u003c\/li\u003e\n\u003cli\u003eTrans-resveratrol is the most bioavailable form of resveratrol.\u003c\/li\u003e\n\u003cli\u003eProHealth's Micronized Trans-Resveratrol powder delivers 1000 mg of pharmaceutical grade, 98% pure, natural trans-resveratrol per serving.\u003c\/li\u003e\n\u003cli\u003eThe particles are micronized to provide superior absorption.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e","brand":"ProHealth Wholesale","offers":[{"title":"Default Title","offer_id":45096791212192,"sku":"PH572","price":190.69,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0507\/7588\/3936\/files\/PH572_FRNT_6.5x10.5_Bag_600x600_REV1026-1.png?v=1791991289"},{"product_id":"prohealth-bulk-micronized-trans-resveratrol-100-grams-ph571","title":"Pure Trans-Resveratrol Micronized Powder - 100 grams","description":"\u003cdiv class=\"product-benefits-copy\"\u003e\n\u003ch2\u003eSupports brain, cardiovascular, cellular and joint health\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eSupports brain health and cognitive function\u003c\/li\u003e\n\u003cli\u003eSupports cellular and DNA health\u003c\/li\u003e\n\u003cli\u003eSupports healthy aging\u003c\/li\u003e\n\u003cli\u003eSupports heart and metabolic health\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cspan style=\"color: #0000ff;\"\u003e\u003ca style=\"color: #0000ff;\" rel=\"noopener noreferrer\" href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0507\/7588\/3936\/files\/PH571_Trans-Resveratrol_Pure_Powder_100g_26083-2.pdf?v=1792685017\" target=\"_blank\"\u003eView Certificate of Analysis \u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003ch3\u003eResearch-Supported Benefits:\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eSupports Brain Health\u003c\/strong\u003e. Research shows that resveratrol, a molecule found in red grapes and wine, may protect the brain from symptoms of brain aging, including improving memory and delaying cognitive decline. The neuroprotective effects of resveratrol come from its sirtuin-activating, inflammation-regulating, mitochondrial-supporting and antioxidant activity. (1-3)\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSupports Cellular and DNA Health\u003c\/strong\u003e. Resveratrol acts as a potent antioxidant, which reduces harmful oxidative stress. It also activates genes called sirtuins. Healthy sirtuin activity helps to fight cellular senescence, support DNA repair, boost mitochondrial function and generate cellular energy through ATP production. (3,4)\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSupports Healthy Aging\u003c\/strong\u003e. Resveratrol activates SIRT1, often referred to as the \"longevity gene.\" Healthy older adults tend to have higher levels of SIRT1 activity, and SIRT1 overexpression can increase lifespan in worms and animals. In humans, SIRT1 supports healthy aging and longevity. (5,6)\u003c\/p\u003e\n\u003cp\u003eSupports Joint Health. Due to its role in supporting healthier inflammatory responses and modulating oxidative stress, resveratrol has exhibited joint-protective effects. (7)\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSupports Heart Health\u003c\/strong\u003e. Resveratrol is well-known for its link to supporting cardiovascular health. Research has found that resveratrol benefits endothelial function, blood vessel health and blood pressure by boosting SIRT1 activity, reducing oxidative stress and increasing nitric oxide production. (8,9)\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSupports Metabolic Health\u003c\/strong\u003e. Resveratrol activates SIRT1, which has been studied for its role in supporting healthier glucose metabolism. People with reduced SIRT1 expression tend to have higher blood sugar, poor glucose control and metabolic disorders. (10)\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eReferences:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e1. Salehi B, Mishra AP, Nigam M, et al. Resveratrol: A Double-Edged Sword in Health Benefits. Biomedicines. 2018;6(3):91. Published 2018 Sep 9. \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6164842\/\" target=\"_blank\"\u003edoi:10.3390\/biomedicines6030091\u003c\/a\u003e \u003cbr\u003e\u003cbr\u003e2. Bastianetto S, Ménard C, Quirion R. Neuroprotective action of resveratrol. Biochim Biophys Acta. 2015;1852(6):1195-1201. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25281824\/\"\u003edoi:10.1016\/j.bbadis.2014.09.011\u003c\/a\u003e \u003cbr\u003e\u003cbr\u003e3. Moraes DS, Moreira DC, Andrade JMO, Santos SHS. Sirtuins, brain and cognition: A review of resveratrol effects. IBRO Rep. 2020;9:46-51. Published 2020 Jun 26. \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7733131\/?report=reader\"\u003edoi:10.1016\/j.ibror.2020.06.004\u003c\/a\u003e\u003cspan lang=\"EN\" data-contrast=\"auto\" style=\"font-size: 11pt; line-height: 21.85px; font-family: Calibri, 'Calibri_EmbeddedFont', 'Calibri_MSFontService', sans-serif;\" class=\"TextRun SCXW41998961 BCX2\"\u003e\u003cspan class=\"NormalTextRun SCXW41998961 BCX2\"\u003e\u003c\/span\u003e\u003c\/span\u003e \u003cbr\u003e\u003cbr\u003e4. Borra MT, Smith BC, Denu JM. Mechanism of human SIRT1 activation by resveratrol. J Biol Chem. 2005;280(17):17187-17195. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/15749705\/\"\u003edoi:10.1074\/jbc.M501250200 \u003c\/a\u003e\u003cbr\u003e\u003cbr\u003e5. Kilic U, Gok O, Erenberk U, et al. A remarkable age-related increase in SIRT1 protein expression against oxidative stress in elderly: SIRT1 gene variants and longevity in human. PLoS One. 2015;10(3):e0117954. Published 2015 Mar 18. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/15749705\/\"\u003edoi:10.1371\/journal.pone.0117954\u003c\/a\u003e \u003cbr\u003e\u003cbr\u003e6. Salminen A, Kaarniranta K. SIRT1: regulation of longevity via autophagy. Cell Signal. 2009;21(9):1356-1360. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/19249351\/\"\u003edoi:10.1016\/j.cellsig.2009.02.014 \u003c\/a\u003e\u003cbr\u003e\u003cbr\u003e7. Nguyen C, Savouret JF, Widerak M, Corvol MT, Rannou F. Resveratrol, Potential Therapeutic Interest in Joint Disorders: A Critical Narrative Review. Nutrients. 2017;9(1):45. Published 2017 Jan 6. \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5295089\/?report=classic\"\u003edoi:10.3390\/nu9010045\u003c\/a\u003e \u003cbr\u003e\u003cbr\u003e8. Marques BCAA, Trindade M, Aquino JCF, et al. Beneficial effects of acute trans-resveratrol supplementation in treated hypertensive patients with endothelial dysfunction. Clin Exp Hypertens. 2018;40(3):218-223. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29431520\/\"\u003edoi:10.1080\/10641963.2017.128874\u003c\/a\u003e1 \u003cbr\u003e\u003cbr\u003e9. Bonnefont-Rousselot D. Resveratrol and Cardiovascular Diseases. Nutrients. 2016;8(5):250. Published 2016 May 2. \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4882663\/\"\u003edoi:10.3390\/nu8050250\u003c\/a\u003e \u003cbr\u003e\u003cbr\u003e10. Hou CY, Tain YL, Yu HR, Huang LT. The Effects of Resveratrol in the Treatment of Metabolic Syndrome. Int J Mol Sci. 2019;20(3):535. Published 2019 Jan 28. \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6387422\/\"\u003edoi:10.3390\/ijms20030535 \u003c\/a\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"summary-copy\"\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eBest Form of Resveratrol.\u003c\/strong\u003e Other resveratrol supplements are typically composed of 50% trans-resveratrol and 50% cis-resveratrol. ProHealth uses trans-resveratrol because it has a higher biological availability.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSuperior Absorption.\u003c\/strong\u003e The particles are micronized to provide superior absorption and the 100 gram container is perfect for people wanting to buy in bulk.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNatural Source.\u003c\/strong\u003e ProHealth’s trans-resveratrol is pure and natural for the highest quality.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHigher Dose.\u003c\/strong\u003e Each serving contains 1000 mg pure and natural trans-resveratrol.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eQuality Manufacturing Practices.\u003c\/strong\u003e All of our products are manufactured in an FDA-registered, GMP-certified facility.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eThird-Party Tested in the USA.\u003c\/strong\u003e Every batch is third-party tested in US laboratories to ensure the highest quality, purity and potency. Certificates of Analysis are available.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAdditional Certifications.\u003c\/strong\u003e Non-GMO, Vegan and Gluten-Free\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cdiv class=\"product-label-copy\"\u003e\n\u003ctable width=\"100%\" cellspacing=\"2\" cellpadding=\"0\" border=\"0\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003cth colspan=\"3\" style=\"font-size: 11pt; font-weight: bold;\" align=\"left\"\u003eSupplement Facts\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd colspan=\"3\" class=\"smalltext\"\u003eServing Size: 1 Scoop\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd colspan=\"3\" class=\"smalltext\"\u003eServings Per Container: 100\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd colspan=\"2\" class=\"smalltext\" style=\"font-weight: bold;\"\u003eAmount Per Serving\u003c\/td\u003e\n\u003ctd style=\"white-space: nowrap;\" class=\"smalltext\" align=\"right\"\u003e\u003cstrong\u003e%DV\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"smalltext\"\u003eVeri-te® Trans-Resveratrol\u003c\/td\u003e\n\u003ctd class=\"smalltext\" style=\"white-space: nowrap;\" align=\"right\"\u003e1000 mg\u003c\/td\u003e\n\u003ctd class=\"smalltext\" style=\"white-space: nowrap;\" align=\"right\"\u003e†\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd colspan=\"3\" class=\"smalltext\"\u003e† Daily Value (DV) not established\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\nREV. 07.25\u003cbr\u003eVeri-te® is a registered trademark of the Lallemand group.\u003cbr\u003e\u003cbr\u003e** Herbal products such as this are likely to have minor color variation from batch to batch because of the geographical and seasonal variations of the raw material.\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eOTHER INGREDIENTS:\u003c\/strong\u003e None.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSUGGESTED DAILY USE:\u003c\/strong\u003e Add one (1) scoop to 8-12 oz of liquid per day, mix thoroughly and drink.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAUTION:\u003c\/strong\u003e For use by healthy adults only. Please consult your physician before use if you are pregnant or nursing, under the age of 18, or are undergoing treatment for a medical condition. Do not exceed the suggested use. \u003cstrong\u003eKEEP OUT OF REACH OF CHILDREN.\u003c\/strong\u003e Store in a cool and dry place after opening.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cem\u003eThis product is sold by weight, not volume. Contents may settle during shipping and handling. Each leveled scoop contains approximately 1,000 mg. A milligram scale is recommended for an exact dose.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\n\u003cdiv class=\"product-how-it-work-copy\"\u003e\n\u003cul\u003e\n\u003cli\u003eResveratrol is a naturally occurring polyphenol that works by activating longevity genes called sirtuins, acting as an antioxidant, regulating inflammatory responses and supporting mitochondrial health.\u003c\/li\u003e\n\u003cli\u003eTrans-resveratrol is the most bioavailable form of resveratrol.\u003c\/li\u003e\n\u003cli\u003eProHealth's Micronized Trans-Resveratrol powder delivers 1000 mg of pharmaceutical grade, 98% pure, natural trans-resveratrol per serving.\u003c\/li\u003e\n\u003cli\u003eThe particles are micronized to provide superior absorption.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e","brand":"ProHealth Wholesale","offers":[{"title":"Default Title","offer_id":45096792391840,"sku":"PH571","price":84.75,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0507\/7588\/3936\/files\/PH571_FRNT_6.5x10.5_Bag-600x600_REV0725.png?v=1784067068"},{"product_id":"prohealth-pterostilbene-pro-250-250-mg-60-capsules-ph577","title":"Pterostilbene Pro 250 - 250 mg, 60 capsules","description":"\u003cdiv class=\"product-benefits-copy\"\u003e\n\u003ch2\u003ePterostilbene is a powerful antioxidant that is similar to, but more bioavailable than resveratrol. Pterostilbene promotes longevity and improves markers associated with heart and brain health.\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eSupports cardiovascular health* \u003c\/li\u003e\n\u003cli\u003ePromotes brain cell health* \u003c\/li\u003e\n\u003cli\u003eActivates sirtuins to support healthy aging \u003c\/li\u003e\n\u003cli\u003eBoosts effectiveness of NMN \u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cspan style=\"color: #0000ff;\"\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0507\/7588\/3936\/files\/PH577_-_COA_Brighton_LOT_23338b_2025-07-17.pdf?v=1753713883\" rel=\"noopener noreferrer\" style=\"color: #0000ff;\" target=\"_blank\"\u003eView Certificate of Analysis \u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003ch3\u003eResearch-Supported Benefits:\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eSupports Longevity.\u003c\/strong\u003e Pterostilbene activates “longevity genes” known as sirtuins. Research shows that activating sirtuins promotes cellular health and extends lifespan of animals. \u003csup\u003e1 2\u003c\/sup\u003e Activating sirtuins aids in DNA repair, promoting cellular stress resistance, regulating autophagy (cellular detoxification) and inflammation. \u003csup\u003e3\u003cbr\u003e\u003cbr\u003e\u003c\/sup\u003e\u003cstrong\u003ePromotes Heart Health.\u003c\/strong\u003e Research shows that pterostilbene promotes heart health in a variety of ways, one of which is reducing oxidative stress of the heart. \u003csup\u003e4\u003c\/sup\u003e Oxidative stress contributes to inflammation and accelerated aging of heart cells. Reducing levels of oxidative stress reduces risk of age-related decline of heart health.\u003cbr\u003e\u003cbr\u003e\u003cstrong\u003eProtects the Aging Brain.\u003c\/strong\u003e Pterostilbene has been shown to reduce neuroinflammation (inflammation of brain cells), reducing oxidative-stress-related damage to brain cells 5. Research shows that neuroinflammation contributes to age-related brain decline symptoms such related to memory and information processing.\u003csup\u003e6\u003cbr\u003e\u003cbr\u003e\u003c\/sup\u003e\u003cstrong\u003eReferences:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e1. Cheng Y, Di S, Fan C, et al. SIRT1 activation by pterostilbene attenuates the skeletal muscle oxidative stress injury and mitochondrial dysfunction induced by ischemia reperfusion injury. Apoptosis. 2016;21(8):905-916. doi:10.1007\/s10495-016-1258-x \u003cbr\u003e\u003cbr\u003e2. Lee SH, Lee JH, Lee HY, Min KJ. Sirtuin signaling in cellular senescence and aging. BMB Rep. 2019;52(1):24-34. doi:10.5483\/BMBRep.2019.52.1.290 doi:10.5483\/BMBRep.2019.52.1.290 \u003cbr\u003e\u003cbr\u003e3. Vazquez BN, Thackray JK, Serrano L. Sirtuins and DNA damage repair: SIRT7 comes to play. Nucleus. 2017;8(2):107-115. doi:10.1080\/19491034.2016.1264552\u003cbr\u003e\u003cbr\u003e4. Kosuru R, Kandula V, Rai U, Prakash S, Xia Z, Singh S. Pterostilbene Decreases Cardiac Oxidative Stress and Inflammation via Activation of AMPK\/Nrf2\/HO-1 Pathway in Fructose-Fed Diabetic Rats. Cardiovasc Drugs Ther. 2018;32(2):147-163. doi:10.1007\/s10557-018-6780-3\u003cbr\u003e\u003cbr\u003e5. Park B, Lee YJ. Pterostilbene Improves Stress-Related Behaviors and Partially Reverses Underlying Neuroinflammatory and Hormonal Changes in Stress-Challenged Mice. J Med Food. 2021;24(3):299-309. doi:10.1089\/jmf.2020.4766\u003cbr\u003e\u003cbr\u003e6. Ahmad MA, Kareem O, Khushtar M, et al. Neuroinflammation: A Potential Risk for Dementia. Int J Mol Sci. 2022;23(2):616. Published 2022 Jan 6. doi:10.3390\/ijms23020616\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"product-how-it-work-copy\"\u003e\n\u003cul\u003e\n\u003cli\u003ePterostilbene has been shown to activate longevity genes known as sirtuins, which play a critical role in regulating cellular aging. \u003c\/li\u003e\n\u003cli\u003eSirtuins require NAD+ for fuel, making pterostilbene and NMN a perfect supplement combination to promote longevity. \u003c\/li\u003e\n\u003cli\u003eBy activating sirtuins, pterostilbene supports DNA stability and promotes DNA repair. \u003c\/li\u003e\n\u003cli\u003ePterostilbene’s antioxidant effects promote heart and brain health by reducing oxidative stress and inflammation. \u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\u003cdiv class=\"product-label-copy\"\u003e\n\u003ctable border=\"0\" cellpadding=\"0\" cellspacing=\"2\" width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003cth align=\"left\" colspan=\"3\" style=\"font-size: 11pt; font-weight: bold;\"\u003eSupplement Facts\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd colspan=\"3\" class=\"smalltext\"\u003eServing Size: 1 Capsule\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd colspan=\"3\" class=\"smalltext\"\u003eServings Per Container: 60\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd colspan=\"2\" class=\"smalltext\" style=\"font-weight: bold;\"\u003eAmount Per Serving\u003c\/td\u003e\n\u003ctd align=\"right\" style=\"white-space: nowrap;\" class=\"smalltext\"\u003e\u003cstrong\u003e%DV\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"smalltext\"\u003ePterostilbene\u003c\/td\u003e\n\u003ctd align=\"right\" class=\"smalltext\" style=\"white-space: nowrap;\"\u003e250 mg\u003c\/td\u003e\n\u003ctd align=\"right\" class=\"smalltext\" style=\"white-space: nowrap;\"\u003e†\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd colspan=\"3\" class=\"smalltext\"\u003e† Daily Value (DV) not established.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\nREV.08.25 \u003cbr\u003e\u003cbr\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eOTHER INGREDIENTS: \u003c\/strong\u003eHypromellose (capsule), rice flour.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSUGGESTED DAILY USE: \u003c\/strong\u003eTake one (1) capsule 1-2 times per day, preferably with food.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAUTION: \u003c\/strong\u003eFor use by healthy adults only. Please consult your physician before use if you are pregnant or nursing, under the age of 18, or are undergoing treatment for a medical condition. Do not exceed the suggested use. \u003cstrong\u003eKEEP OUT OF REACH OF  CHILDREN\u003c\/strong\u003e. Store in a cool and dry place aer opening.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"summary-copy\"\u003e\n\u003cp\u003e\u003cstrong\u003eClinical-Supported Dosing.\u003c\/strong\u003e ProHealth Longevity’s Pterostilbene Pro 250 contains 250 mg of pterostilbene per serving, a clinically effective dose to promote longevity.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eQuality Manufacturing Practices.\u003c\/strong\u003e All of our products are manufactured in an FDA-registered, GMP-certified facility.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eThird-Party Tested in the USA.\u003c\/strong\u003e Every batch is third-party tested in US laboratories to ensure the highest quality, purity and potency. Certificates of Analysis are available.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"ProHealth Wholesale","offers":[{"title":"Default Title","offer_id":45096795078816,"sku":"PH577","price":29.15,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0507\/7588\/3936\/files\/PH577_175ML_FRNT_600x600_REV0825-2.png?v=1780603447"},{"product_id":"prohealth-trans-resveratrol-1000-mg-60-capsules-ph528","title":"Trans-Resveratrol Plus - 1000 mg per serving, 60 capsules","description":"\u003cdiv class=\"product-benefits-copy\"\u003e\n\u003ch2\u003eSupports Brain, Cardiovascular and Joint Health\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eSupports brain health and cognitive function\u003c\/li\u003e\n\u003cli\u003eSupports cellular and DNA health\u003c\/li\u003e\n\u003cli\u003eSupports healthy aging\u003c\/li\u003e\n\u003cli\u003eSupports heart and metabolic health\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cspan style=\"color: #0000ff;\"\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0507\/7588\/3936\/files\/PH528-_COA_Brighton_LOT_23192_2024-10-30_1.pdf?v=1733499816\" style=\"color: #0000ff;\" target=\"_blank\"\u003eView Certificate of Analysis »\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003ch3\u003eResearch-Supported Benefits:\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003e Supports Brain Health\u003c\/strong\u003e. Research shows that resveratrol, a molecule found in red grapes and wine, may protect the brain from symptoms of brain aging, including improving memory and delaying cognitive decline. The neuroprotective effects of resveratrol come from its sirtuin-activating, inflammation-regulating, mitochondrial-supporting and antioxidant activity. (1-3)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSupports Cellular and DNA Health\u003c\/strong\u003e. Resveratrol acts as a potent antioxidant, which reduces harmful oxidative stress. It also activates genes called sirtuins. Healthy sirtuin activity helps to fight cellular senescence, support DNA repair, boost mitochondrial function and generate cellular energy through ATP production. (3,4)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSupports Healthy Aging\u003c\/strong\u003e. Resveratrol activates SIRT1, often referred to as the \"longevity gene.\" Healthy older adults tend to have higher levels of SIRT1 activity, and SIRT1 overexpression can increase lifespan in worms and animals. In humans, SIRT1 supports healthy aging and longevity. (5,6)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSupports Joint Health\u003c\/strong\u003e. Due to its role in supporting healthier inflammatory responses and modulating oxidative stress, resveratrol has exhibited joint-protective effects. (7)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSupports Heart Health\u003c\/strong\u003e. Resveratrol is well-known for its link to supporting cardiovascular health. Research has found that resveratrol benefits endothelial function, blood vessel health and blood pressure by boosting SIRT1 activity, reducing oxidative stress and increasing nitric oxide production. (8,9)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSupports Metabolic Health\u003c\/strong\u003e. Resveratrol activates SIRT1, which has been studied for its role in supporting healthier glucose metabolism. People with reduced SIRT1 expression tend to have higher blood sugar, poor glucose control and metabolic disorders. (10)\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eReferences:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e1. Salehi B, Mishra AP, Nigam M, et al. Resveratrol: A Double-Edged Sword in Health Benefits. Biomedicines. 2018;6(3):91. Published 2018 Sep 9. doi:10.3390\/biomedicines6030091 \u003cbr\u003e\u003cbr\u003e2. Bastianetto S, Ménard C, Quirion R. Neuroprotective action of resveratrol. Biochim Biophys Acta. 2015;1852(6):1195-1201. doi:10.1016\/j.bbadis.2014.09.011 \u003cbr\u003e\u003cbr\u003e3. Moraes DS, Moreira DC, Andrade JMO, Santos SHS. Sirtuins, brain and cognition: A review of resveratrol effects. IBRO Rep. 2020;9:46-51. Published 2020 Jun 26. doi:10.1016\/j.ibror.2020.06.004 \u003cbr\u003e\u003cbr\u003e4. Borra MT, Smith BC, Denu JM. Mechanism of human SIRT1 activation by resveratrol. J Biol Chem. 2005;280(17):17187-17195. doi:10.1074\/jbc.M501250200 \u003cbr\u003e\u003cbr\u003e5. Kilic U, Gok O, Erenberk U, et al. A remarkable age-related increase in SIRT1 protein expression against oxidative stress in elderly: SIRT1 gene variants and longevity in human. PLoS One. 2015;10(3):e0117954. Published 2015 Mar 18. \u003cbr\u003e\u003cbr\u003e6. Salminen A, Kaarniranta K. SIRT1: regulation of longevity via autophagy. Cell Signal. 2009;21(9):1356-1360. doi:10.1016\/j.cellsig.2009.02.014 \u003cbr\u003e\u003cbr\u003e7. Nguyen C, Savouret JF, Widerak M, Corvol MT, Rannou F. Resveratrol, Potential Therapeutic Interest in Joint Disorders: A Critical Narrative Review. Nutrients. 2017;9(1):45. Published 2017 Jan 6. doi:10.3390\/nu9010045 \u003cbr\u003e\u003cbr\u003e8. Marques BCAA, Trindade M, Aquino JCF, et al. Beneficial effects of acute trans-resveratrol supplementation in treated hypertensive patients with endothelial dysfunction. Clin Exp Hypertens. 2018;40(3):218-223. doi:10.1080\/10641963.2017.1288741 \u003cbr\u003e\u003cbr\u003e9. Bonnefont-Rousselot D. Resveratrol and Cardiovascular Diseases. Nutrients. 2016;8(5):250. Published 2016 May 2. doi:10.3390\/nu8050250 \u003cbr\u003e\u003cbr\u003e10. Hou CY, Tain YL, Yu HR, Huang LT. The Effects of Resveratrol in the Treatment of Metabolic Syndrome. Int J Mol Sci. 2019;20(3):535. Published 2019 Jan 28. doi:10.3390\/ijms20030535\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"summary-copy\"\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eBest Form of Resveratrol.\u003c\/strong\u003e Other resveratrol supplements are typically composed of 50% trans-resveratrol and 50% cis-resveratrol. ProHealth uses trans-resveratrol because it has a higher biological availability.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNatural Source.\u003c\/strong\u003e ProHealth’s trans-resveratrol is pure and natural for the highest quality.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHigher Dose.\u003c\/strong\u003e Each serving contains 1000 mg pure and natural trans-resveratrol.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eUnique Formulation.\u003c\/strong\u003e Compared to other products, ProHealth Longevity’s Trans-Resveratrol also includes 420 mg of a proprietary blend of quercetin, organic red wine extract, organic decaf green tea extract and BioPerine® to support absorption. These select co-factors and BioPerine® included in this formula can improve absorption and increase C-max blood levels by up to 1544% compared to regular resveratrol supplements.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eQuality Manufacturing Practices.\u003c\/strong\u003e All of our products are manufactured in an FDA-registered, GMP-certified facility.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eThird-Party Tested in the USA.\u003c\/strong\u003e Every batch is third-party tested in US laboratories to ensure the highest quality, purity and potency. Certificates of Analysis are available.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAdditional Certifications.\u003c\/strong\u003e Non-GMO, Vegan and Gluten-Free\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"product-label-copy\"\u003e\n\u003ctable border=\"0\" cellpadding=\"0\" cellspacing=\"2\" width=\"100%\" style=\"height: 174.883px;\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 20.5333px;\"\u003e\n\u003cth align=\"left\" colspan=\"3\" style=\"font-size: 11pt; font-weight: bold; height: 20.5333px;\"\u003eSupplement Facts\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 17.15px;\"\u003e\n\u003ctd colspan=\"3\" class=\"smalltext\" style=\"height: 17.15px;\"\u003eServing Size: 2 Capsules\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 17.15px;\"\u003e\n\u003ctd colspan=\"3\" class=\"smalltext\" style=\"height: 17.15px;\"\u003eServings Per Container: 30\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 17.15px;\"\u003e\n\u003ctd colspan=\"2\" class=\"smalltext\" style=\"font-weight: bold; height: 17.15px;\"\u003eAmount Per Serving\u003c\/td\u003e\n\u003ctd align=\"right\" class=\"smalltext\" style=\"white-space: nowrap; height: 17.15px;\"\u003e\u003cstrong\u003e%DV\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 17.15px;\"\u003e\n\u003ctd class=\"smalltext\" style=\"height: 17.15px;\"\u003ePure  Veri-te® Trans-Resveratrol\u003c\/td\u003e\n\u003ctd align=\"right\" class=\"smalltext\" style=\"white-space: nowrap; height: 17.15px;\"\u003e1000 mg\u003c\/td\u003e\n\u003ctd align=\"right\" class=\"smalltext\" style=\"white-space: nowrap; height: 17.15px;\"\u003e†\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 68.6px;\"\u003e\n\u003ctd class=\"smalltext\" style=\"height: 68.6px;\"\u003e\n\u003cstrong\u003eProprietary Blend\u003c\/strong\u003e\u003cbr\u003eQuercetin Dihydrate (from \u003cem\u003eSophora japonica\u003c\/em\u003e Flower Extract), Red Wine (\u003cem\u003eVitis vinifera\u003c\/em\u003e) Fruit Extract, Green Tea Leaf Extract, BioPerine® Black Pepper Fruit Extract (95% Piperine)®\u003c\/td\u003e\n\u003ctd align=\"right\" class=\"smalltext\" style=\"white-space: nowrap; height: 68.6px;\"\u003e420 mg\u003c\/td\u003e\n\u003ctd align=\"right\" class=\"smalltext\" style=\"white-space: nowrap; height: 68.6px;\"\u003e†\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 17.15px;\"\u003e\n\u003ctd colspan=\"3\" class=\"smalltext\" style=\"height: 17.15px;\"\u003e† Daily Value (DV) not established\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\nREV.08.25\u003cbr\u003eVeri-te® is a registered trademark of the Lallemand group. BioPerine® is a registered trademark of Sabinsa, Co.\u003cbr\u003e\u003cbr\u003e** Herbal products such as this are likely to have minor color variation from batch to batch because of the geographical and seasonal variations of the raw material.\u003cbr\u003e\u003cbr\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eOTHER INGREDIENTS: \u003c\/strong\u003eHypromellose (capsule), rice flour.\u003cstrong\u003e\u003c\/strong\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSUGGESTED DAILY USE: \u003c\/strong\u003eTake two (2) capsules per day, with food, preferably in the morning.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAUTION: \u003c\/strong\u003eFor use by healthy adults only. Please consult your physician before use if you are pregnant or nursing, under the age of 18, or are undergoing treatment for a medical condition. Do not exceed the suggested use. KEEP OUT OF REACH OF CHILDREN. Store in a cool and dry place after opening.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNOTE:\u003c\/strong\u003e Store in a cool, dry place, away from direct sunlight. Do not use if tamper-evident packaging is broken. \u003cstrong\u003eKEEP OUT OF REACH OF CHILDREN.\u003c\/strong\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e","brand":"ProHealth Wholesale","offers":[{"title":"Default Title","offer_id":45096814117024,"sku":"PH528","price":31.08,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0507\/7588\/3936\/files\/PH528_175CC_FRNT_600x600-REV0825-1.png?v=1770653310"},{"product_id":"prohealth-nmn-pro-complete-capsules-120-capsules-ph633","title":"ProHealth Longevity NMN Pro™ Complete Capsules - 120 Capsules","description":"\u003cdiv class=\"product-benefits-copy\"\u003e\n\u003ch2\u003eA Perfectly Balanced Combination of NMN, Trans-Resveratrol and TMG\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eNMN supplementation has been found to support various parameters of health, including physical endurance and muscle strength, neurological function, heart health, blood sugar management, body weight, and gene expression.\u003c\/li\u003e\n\u003cli\u003eNicotinamide mononucleotide (NMN) is a derivative of the B-vitamin niacin that dramatically improves health and longevity by serving as a precursor to NAD+.\u003c\/li\u003e\n\u003cli\u003eNMN Pro Complete is the first and only perfectly balanced combination of NMN, Trans-Resveratrol, and TMG on the market. Instead of having to take three separate supplements each day, you can now get the ideal balance of all three in a convenient capsule serving.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cspan style=\"color: #0000ff;\"\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0507\/7588\/3936\/files\/PH633_-_COA_Brighton_LOT_26445_2026.08.11_2.pdf?v=1792087544\" style=\"color: #0000ff;\" target=\"_blank\"\u003eView Certificate of Analysis »\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSupports Longevity.\u003c\/strong\u003e Studies have shown that boosting NAD+ synthesis in the body extends the lifespan of yeast, worms and flies. (1)\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eBlood Sugar Regulation.\u003c\/strong\u003e As we age, we have more trouble processing glucose, leading to higher blood sugar—a known contributor to several metabolic-related disorders. Supplemental NMN has been shown to improve several markers of skeletal muscle glucose metabolism that are commonly dysregulated in people with metabolic disorders. (2)\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSupports Metabolism and Healthy Weight.\u003c\/strong\u003e Although excessive body weight can develop at any age, adults over age 40 are particularly susceptible to age-related weight gain as metabolism slows down and body composition is altered to favor fat over lean muscle. As obese individuals have reductions in both NAD+ levels and ATP (energy) production, replenishing NAD+ through NMN can help to reverse this while improving metabolic pathways to maintain a healthy weight. (3,4,5)\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSupports Healthy Cognition:\u003c\/strong\u003e Declining cognitive function with age is related to a reduced NAD+ levels that impair mitochondrial function. Replenishing NAD+ stores through NMN may be able to prevent this dysfunction. (6,7,8,9)\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSupports Healthy Skin:\u003c\/strong\u003e In our 30s and 40s, the appearance of our skin can start to show signs of age. Several studies have examined how boosting NAD+ levels in the skin prevents premature skin aging or supports a healthier external appearance. (10,11)\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eReferences:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e1. Fang EF, Kassahun H, Croteau DL, et al. NAD+ Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair. Cell Metab. 2016;24(4):566-581. doi:10.1016\/j.cmet.2016.09.004 \u003cbr\u003e\u003cbr\u003e2. Yoshino M, Yoshino J, Kayser BD, et al. Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women. Science. 2021;372(6547):1224-1229. doi:10.1126\/science.abe9985 \u003cbr\u003e\u003cbr\u003e3. Kim M, Seol J, Sato T, Fukamizu Y, Sakurai T, Okura T. Effect of 12-Week Intake of Nicotinamide Mononucleotide on Sleep Quality, Fatigue, and Physical Performance in Older Japanese Adults: A Randomized, Double-Blind Placebo-Controlled Study. Nutrients. 2022;14(4):755. Published 2022 Feb 11. doi:10.3390\/nu14040755 \u003cbr\u003e\u003cbr\u003e4. Liao B, Zhao Y, Wang D, Zhang X, Hao X, Hu M. Nicotinamide mononucleotide supplementation enhances aerobic capacity in amateur runners: a randomized, double-blind study. J Int Soc Sports Nutr. 2021;18(1):54. Published 2021 Jul 8. doi:10.1186\/s12970-021-00442- \u003cbr\u003e\u003cbr\u003e5. Yoshino J, Mills KF, Yoon MJ, Imai S. Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice. Cell Metab. 2011;14(4):528-536. doi:10.1016\/j.cmet.2011.08.014 \u003cbr\u003e\u003cbr\u003e6. Mills KF, Yoshida S, Stein LR, et al. Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice. Cell Metab. 2016;24(6):795-806. doi:10.1016\/j.cmet.2016.09.013 \u003cbr\u003e\u003cbr\u003e7. Tarantini S, Valcarcel-Ares MN, Toth P, et al. Nicotinamide mononucleotide (NMN) supplementation rescues cerebromicrovascular endothelial function and neurovascular coupling responses and improves cognitive function in aged mice. Redox Biol. 2019;24:101192. doi:10.1016\/j.redox.2019.101192 \u003cbr\u003e\u003cbr\u003e8. Kiss T, Nyúl-Tóth Á, Balasubramanian P, et al. Nicotinamide mononucleotide (NMN) supplementation promotes neurovascular rejuvenation in aged mice: transcriptional footprint of SIRT1 activation, mitochondrial protection, anti-inflammatory, and anti-apoptotic effects. Geroscience. 2020;42(2):527-546. doi:10.1007\/s11357-020-00165-5 \u003cbr\u003e\u003cbr\u003e9. Wang X, Hu X, Yang Y, Takata T, Sakurai T. Nicotinamide mononucleotide protects against β-amyloid oligomer-induced cognitive impairment and neuronal death. Brain Res. 2016;1643:1-9. doi:10.1016\/j.brainres.2016.04.060 \u003cbr\u003e\u003cbr\u003e10. Katayoshi T, Nakajo T, Tsuji-Naito K. Restoring NAD+ by NAMPT is essential for the SIRT1\/p53-mediated survival of UVA- and UVB-irradiated epidermal keratinocytes. J Photochem Photobiol B. 2021;221:112238. doi:10.1016\/j.jphotobiol.2021.112238 \u003cbr\u003e\u003cbr\u003e11. Feng Z, Qin Y, Huo F, et al. NMN recruits GSH to enhance GPX4-mediated ferroptosis defense in UV irradiation induced skin injury. Biochim Biophys Acta Mol Basis Dis. 2022;1868(1):166287. doi:10.1016\/j.bbadis.2021.166287\u003c\/p\u003e\n\u003cdiv class=\"product-how-it-work-copy\"\u003e\n\u003cul\u003e\n\u003cli\u003eNicotinamide mononucleotide (NMN) is a derivative of the B-vitamin niacin that dramatically improves health and longevity by serving as a precursor to NAD+, a compound that plays a crucial role in energy production, metabolism and gene expression in the body. When we boost NMN levels in the body, we can enhance the biosynthesis of NAD+ and alleviate symptoms associated with depletion of this crucial nutrient. NMN supplementation has been found to improve various parameters of health, including physical endurance and muscle strength, brain health, heart health, body weight and gene expression.\u003c\/li\u003e\n\u003cli\u003eNMN and trans-resveratrol work synergistically, which is why longevity experts recommend taking them together for the greatest effectiveness. This dynamic duo has been likened to the operation of a car, with NMN as the fuel and trans-resveratrol as the accelerator pedal.\u003c\/li\u003e\n\u003cli\u003eRegular resveratrol is composed of 50% trans-resveratrol and 50% cis-resveratrol. Because research suggests that only the trans form has valuable biological activity, NMN Pro Complete contains pure, natural, pharmaceutical grade trans-resveratrol to maximize its effectiveness.\u003c\/li\u003e\n\u003cli\u003eTMG, also known as betaine anhydrous, is an amino acid that supports the body's methylation processes. These processes are known to decline with age and may also be affected by common gene mutations. Also, NMN supplementation may require the use of methyl groups to help facilitate the conversion of NAD+ in your cells, thereby activating sirtuin genes and promoting longevity.*\u003c\/li\u003e\n\u003cli\u003eMany top anti-aging experts suggest that safeguarding against methyl depletion may be a wise proactive step to augment your NMN intake. TMG, the choice of many of those experts, is an excellent way to help support your body's ability to maintain an adequate methyl pool.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"product-label-copy\"\u003e\n\u003ctable width=\"100%\" cellspacing=\"2\" cellpadding=\"0\" border=\"0\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003cth colspan=\"3\" style=\"font-size: 11pt; font-weight: bold;\" align=\"left\"\u003eSupplement Facts\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd colspan=\"3\" class=\"smalltext\"\u003eServing Size: 4 Capsules\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd colspan=\"3\" class=\"smalltext\"\u003eServings Per Container: 30\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd colspan=\"2\" class=\"smalltext\" style=\"font-weight: bold;\"\u003eAmount Per Serving\u003c\/td\u003e\n\u003ctd style=\"white-space: nowrap;\" class=\"smalltext\" align=\"right\"\u003e\u003cstrong\u003e%DV\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"smalltext\"\u003eUthever® β-Nicotinamide Mononucleotide (NMN)\u003cbr\u003e\n\u003c\/td\u003e\n\u003ctd class=\"smalltext\" style=\"white-space: nowrap;\" align=\"right\"\u003e1000 mg\u003c\/td\u003e\n\u003ctd class=\"smalltext\" style=\"white-space: nowrap;\" align=\"right\"\u003e†\u003cbr\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"smalltext\"\u003eVeri-te® Pure trans-Resveratrol)\u003c\/td\u003e\n\u003ctd class=\"smalltext\" style=\"white-space: nowrap;\" align=\"right\"\u003e1000 mg\u003c\/td\u003e\n\u003ctd class=\"smalltext\" style=\"white-space: nowrap;\" align=\"right\"\u003e†\u003cbr\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"smalltext\"\u003eTrimethylglycine (TMG)\u003c\/td\u003e\n\u003ctd class=\"smalltext\" style=\"white-space: nowrap;\" align=\"right\"\u003e500 mg\u003c\/td\u003e\n\u003ctd class=\"smalltext\" style=\"white-space: nowrap;\" align=\"right\"\u003e†\u003cbr\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd colspan=\"3\" class=\"smalltext\"\u003e† Daily Value (DV) not established\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\nREV.09.25\u003cbr\u003e\u003cbr\u003eUthever® is a registered trademark of Effepharm (Shanghai) Co., Ltd. Veri-te® is a registered trademark of the Lallemand group.\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eOTHER INGREDIENTS:\u003c\/strong\u003e Hypromellose (capsule), microcrystalline cellulose.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSUGGESTED DAILY USE:\u003c\/strong\u003e Take four (4) capsules per day, with or without food, preferably in the morning.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAUTION:\u003c\/strong\u003e For use by healthy adults only. Please consult your physician before use if you are pregnant or nursing, under the age of 18, or are undergoing treatment for a medical condition. Do not exceed the suggested use. \u003cstrong\u003eKEEP OUT OF REACH OF CHILDREN.\u003c\/strong\u003e Store in a cool and dry place after opening.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"summary-copy\"\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eOnly Clincially-Proven NMN.\u003c\/strong\u003e ProHealth’s NMN is the only clinically-proven NMN to boost NAD+ levels in a peer-reviewed, double-blind, placebo-controlled, published, clinical study. Results of the study indicated a 38% increase in NAD+ levels and 12-year reversal in biological age.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eUnique Trio of Longevity-Supporting Ingredients at High Doses.\u003c\/strong\u003eNMN Pro Complete is the first and only perfectly balanced combination of NMN, Trans-Resveratrol and TMG on the market. Instead of having to take three separate supplements each day, you can now get the ideal balance of all three in one convenient serving.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNew Capsule Form.\u003c\/strong\u003e For people who don’t want to take powdered supplements, capsules are an easy, convenient, and portable way to get your NMN.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSolvent-Free.\u003c\/strong\u003e Compared to other NMN products, ours is made without any chemical solvents.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eQuality Manufacturing Practices.\u003c\/strong\u003e All of our products are manufactured in an FDA-registered, GMP-certified facility.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eThird-Party Tested in the USA.\u003c\/strong\u003e Every batch is third-party tested in US laboratories to ensure the highest quality, purity and potency. Certificates of Analysis are available.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cstrong\u003eBe Aware of Fake NMN:\u003c\/strong\u003e Fraudulent companies are always attempting to out-price competitors by using NMN fake ingredients to gain market share, which is not fair to you, the consumer, or the reputable companies, like ProHealth that spends time and resources to ensure a safe and pure NMN product.\u003c\/div\u003e\n\u003c\/div\u003e","brand":"ProHealth Wholesale","offers":[{"title":"Default Title","offer_id":45844902281376,"sku":"PH633","price":85.95,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0507\/7588\/3936\/files\/PH633_FRNT_250CC_600x600_Rev1024.png?v=1738610512"},{"product_id":"prohealth-l-ergothinoneine-25-mg-30-capsules-ph646","title":"L-Ergothinoneine - 25 mg per serving, 30 capsules","description":"\u003cdiv class=\"product-benefits-copy\"\u003e\n\u003ch2\u003eErgothioneine is a powerful amino acid that helps fight the signs of aging and supports numerous aspects of health.\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eSupports longevity by aiding in telomere length maintenence \u003csup\u003e1 \u003c\/sup\u003e\n\u003c\/li\u003e\n\u003cli\u003eCombats oxidative stress in the brain to support cognition \u003csup\u003e2\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003cli\u003eProtects the heart and is associated with reduced cardiovascular mortality \u003csup\u003e3\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cspan style=\"color: #0000ff;\"\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0507\/7588\/3936\/files\/PH518-COA-2025-11-11_Shopify.jpg?v=1763394604\" rel=\"noopener noreferrer\" style=\"color: #0000ff;\" target=\"_blank\"\u003eView Certificate of Analysis \u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003ch3\u003eResearch-Supported Benefits:\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eSupports Longevity. \u003c\/strong\u003eResearch shows that ergothioneine supports longevity by protecting against accelerated telomere shortening. (1) Longer telomeres are a powerful predictor of increased lifespan and healthspan. (4)\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMaintains Cellular Health.\u003c\/strong\u003e Ergothioneine has been shown to reduce levels of oxidative stress. High levels of oxidative stress may contribute to DNA damage, a decline in ATP (cellular energy) production and elevated inflammatory markers. (5)\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePromotes Heart Health. \u003c\/strong\u003eBy reducing oxidative stress, ergothioneine exhibits powerful cardioprotective properties. Oxidative stress is associated with accelerated aging of heart cells, studies show ergothioneine reduces cardiac-related mortality risk. (6)\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eEnhances Brain Health. \u003c\/strong\u003eLow levels of ergothioneine are correlated with neurodegeneration and cognitive impairment. (7) Animal studies have found that administration of ergothioneine improves markers of memory and mood. (8)\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eImproves Performance. \u003c\/strong\u003eResearch suggests ergothioneine may improve markers associated with fitness and muscle health. One study found that administration ergothioneine to mice increased time to exhaustion during aerobic activity and enhanced protein synthesis post-exercise. (9)\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eReferences:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e1. Samuel P, Tsapekos M, de Pedro N, Liu AG, Casey Lippmeier J, Chen S. Ergothioneine Mitigates Telomere Shortening under Oxidative Stress Conditions. J Diet Suppl. 2022;19(2):212-225. doi:10.1080\/19390211.2020.1854919 \u003cbr\u003e\u003cbr\u003e2. Wijesinghe P, Whitmore CA, Campbell M, et al. Ergothioneine, a dietary antioxidant improves amyloid beta clearance in the neuroretina of a mouse model of Alzheimer's disease. Front Neurosci. 2023;17:1107436. Published 2023 Mar 14. doi:10.3389\/fnins.2023.1107436 \u003cbr\u003e\u003cbr\u003e3. Dare A, Elrashedy AA, Channa ML, Nadar A. Cardioprotective Effects and in-silico Antioxidant Mechanism of L-Ergothioneine in Experimental Type-2 Diabetic Rats. Cardiovasc Hematol Agents Med Chem. 2022;20(2):133-147. doi:10.2174\/1871525719666210809122541 \u003cbr\u003e\u003cbr\u003e4. Heidinger BJ, Blount JD, Boner W, Griffiths K, Metcalfe NB, Monaghan P. Telomere length in early life predicts lifespan. Proc Natl Acad Sci U S A. 2012;109(5):1743-1748. doi:10.1073\/pnas.1113306109 \u003cbr\u003e\u003cbr\u003e5. Fu TT, Shen L. Ergothioneine as a Natural Antioxidant Against Oxidative Stress-Related Diseases. Front Pharmacol. 2022;13:850813. Published 2022 Mar 18. doi:10.3389\/fphar.2022.850813 \u003cbr\u003e\u003cbr\u003e6. Smith E, Ottosson F, Hellstrand S, et al. Ergothioneine is associated with reduced mortality and decreased risk of cardiovascular disease. Heart. 2020;106(9):691-697. doi:10.1136\/heartjnl-2019-315485 \u003cbr\u003e\u003cbr\u003e7. Wu LY, Kan CN, Cheah IK, et al. Low Plasma Ergothioneine Predicts Cognitive and Functional Decline in an Elderly Cohort Attending Memory Clinics. Antioxidants (Basel). 2022;11(9):1717. Published 2022 Aug 30. doi:10.3390\/antiox11091717 \u003cbr\u003e\u003cbr\u003e8. Ishimoto T, Kato Y. Ergothioneine in the brain. FEBS Lett. 2022;596(10):1290-1298. doi:10.1002\/1873-3468.14271 \u003cbr\u003e\u003cbr\u003e9. Fovet T, Guilhot C, Delobel P, Chopard A, Py G, Brioche T. Ergothioneine Improves Aerobic Performance Without Any Negative Effect on Early Muscle Recovery Signaling in Response to Acute Exercise. Front Physiol. 2022;13:834597. Published 2022 Feb 9. doi:10.3389\/fphys.2022.834597 \u003cbr\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"product-how-it-work-copy\"\u003e\n\u003cul\u003e\n\u003cli\u003eErgothioneine is an amino acid that your body is unable to make on its own but can be obtained from eating foods such as certain types of mushrooms and organ meat.\u003c\/li\u003e\n\u003cli\u003eAs you age, levels of ergothioneine decline in the body, potentially contributing to a decline in cellular, brain, heart, and muscle health.\u003c\/li\u003e\n\u003cli\u003eErgothioneine is absorbed in the small intestine and transported throughout the body via a specific transporter known as the Organic Cation Transporter 1 (OCTN1). This transporter is highly selective for ergothioneine, allowing it to enter cells efficiently.\u003c\/li\u003e\n\u003cli\u003eOnce inside the cells, ergothioneine primarily exerts its effects as a potent antioxidant. It works by donating electrons to neutralize harmful free radicals and reactive oxygen species (ROS) that are generated during normal cellular metabolism and in response to environmental stressors.\u003c\/li\u003e\n\u003cli\u003eAdministration of ergothioneine in animal studies has been shown to reduce oxidative stress, mediate inflammatory markers, and promote cellular, brain, and heart health.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"product-label-copy\"\u003e\n\u003ctable width=\"100%\" cellspacing=\"2\" cellpadding=\"0\" border=\"0\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003cth colspan=\"3\" style=\"font-size: 11pt; font-weight: bold;\" align=\"left\"\u003eSupplement Facts\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd colspan=\"3\" class=\"smalltext\"\u003eServing Size: 1 Capsule\u003cbr\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd colspan=\"3\" class=\"smalltext\"\u003eServings Per Container: 30\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd colspan=\"2\" class=\"smalltext\" style=\"font-weight: bold;\"\u003eAmount Per Serving\u003c\/td\u003e\n\u003ctd style=\"white-space: nowrap;\" class=\"smalltext\" align=\"right\"\u003e\u003cstrong\u003e%DV\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"smalltext\"\u003eL-Ergothioneine\u003c\/td\u003e\n\u003ctd class=\"smalltext\" style=\"white-space: nowrap;\" align=\"right\"\u003e25 mg\u003c\/td\u003e\n\u003ctd class=\"smalltext\" style=\"white-space: nowrap;\" align=\"right\"\u003e†\u003cbr\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd colspan=\"3\" class=\"smalltext\"\u003e† Daily Value (DV) not established\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\nREV.08.25\u003cbr\u003e\u003cbr\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eOTHER INGREDIENTS: \u003c\/strong\u003eHypromellose (capsule), rice flour.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSUGGESTED DAILY USE:\u003c\/strong\u003e Take (1) capsule per day, with or without food.\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAUTION:\u003c\/strong\u003e For use by healthy adults only. Please consult your physician before use if you are pregnant or nursing, under the age of 18, or are undergoing treatment for a medical condition. Do not exceed the suggested use. \u003cstrong\u003eKEEP OUT OF REACH OF CHILDREN\u003c\/strong\u003e. Store in a cool and dry place after opening.\u003cbr\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"summary-copy\"\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eUnique Formulation. \u003c\/strong\u003eCompared to the majority of products on the market with lower doses, ProHealth's Ergothioneine contains a clinically effective dose of 25 mg of ergothioneine per serving.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eQuality Manufacturing Practices.\u003c\/strong\u003e All of our products are manufactured in an FDA-registered, GMP-certified facility.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eThird-Party Tested in the USA.\u003c\/strong\u003e Every batch is third-party tested in US laboratories to ensure the highest quality, purity and potency. Certificates of Analysis are available.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e","brand":"ProHealth Wholesale","offers":[{"title":"Default Title","offer_id":47740044279968,"sku":"PH646","price":39.95,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0507\/7588\/3936\/files\/PH646_175ML_FRNT_600x600_0825-1.png?v=1780596740"},{"product_id":"prohealth-astaxanthin-12-mg-30-capsules-ph645","title":"Astaxanthin - 12 mg, 30 capsules","description":"\u003cdetails\u003e\n\u003ch2\u003eBenefits:\u003c\/h2\u003e\n\u003cp\u003eAstaxanthin is a powerful antioxidant found in microalgae (and the fish that eat the algae) that has potential to reduce oxidative stress, enhance heart health, and support healthy brain aging.\u003c\/p\u003e\n\u003cbr\u003e\n\u003cul\u003e\n\u003cli\u003eActs as an antoixidant to reduce oxidative stress\u003c\/li\u003e\n\u003cli\u003eEnhances heart function by supporting healthy blood flow\u003c\/li\u003e\n\u003cli\u003ePromotes more youthful brain function due to its ability to cross the blood brain barrier and and protect brain cells from damage\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cspan style=\"color: #0000ff;\"\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0507\/7588\/3936\/files\/PH645_-_COA_Qalitex_LOT_2506092_2025-09-22.pdf?v=1759357941\" style=\"color: #0000ff;\" target=\"_blank\"\u003eView Certificate of Analysis \u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cbr\u003e\n\u003ch3\u003eResearch-Supported Benefits:\u003c\/h3\u003e\n\u003cbr\u003e\n\u003cp\u003e\u003cstrong\u003eSupports Cellular Health. \u003c\/strong\u003eStudies suggest astaxanthin supports cellular health by reducing oxidative stress, which contributes to accelerated cellular aging. Astaxanthin’s antioxidant properties protect cells from oxidative damage, improving mitochondrial function. (1)\u003c\/p\u003e\n\u003cbr\u003e\n\u003cp\u003e\u003cstrong\u003eProtects Against Brain Aging.\u003c\/strong\u003e Research shows astaxanthin exhibits neuroprotective effects, reducing symptoms associated with brain aging. The neuroprotective effects of astaxanthin may be attributed to astaxanthin’s ability to increase BDNF (brain-derived neurotrophic factor), a critical protein that plays a role in memory and learning. (2)\u003c\/p\u003e\n\u003cbr\u003e\n\u003cp\u003e\u003cstrong\u003eEnhances Heart Health. \u003c\/strong\u003eAnimal studies suggest that astaxanthin has cardioprotective properties, reducing cardiac dysfunction associated with elevated blood pressure. (3) Additional research shows that by activating SIRT1, astaxanthin may protect against cardiac damage resulting from a high-fat diet. (4)\u003c\/p\u003e\n\u003cbr\u003e\n\u003cp\u003e\u003cstrong\u003ePromotes Joint Health. \u003c\/strong\u003eAstaxanthin supports joint health by inhibiting inflammatory-related processes within cartilage cells and reducing degradation of cartilage. (5)\u003c\/p\u003e\n\u003cbr\u003e\n\u003cp\u003e\u003cstrong\u003ePromotes Eye Health. \u003c\/strong\u003eBy improving ocular circulation and protecting against eye-damage associated with computer work, astaxanthin’s powerful antioxidant properties support visual function. (6)\u003c\/p\u003e\n\u003cbr\u003e\n\u003cp\u003e\u003cstrong\u003eReferences:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e1. Kim SH, Kim H. Inhibitory Effect of Astaxanthin on Oxidative Stress-Induced Mitochondrial Dysfunction-A Mini-Review. Nutrients. 2018;10(9):1137. Published 2018 Aug 21. doi:10.3390\/nu10091137 \u003cbr\u003e\u003cbr\u003e2. Liu N, Zeng L, Zhang YM, Pan W, Lai H. Astaxanthin alleviates pathological brain aging through the upregulation of hippocampal synaptic proteins. Neural Regen Res. 2021;16(6):1062-1067. doi:10.4103\/1673-5374.300460 \u003cbr\u003e\u003cbr\u003e3. Khodir SA, Sweed E, Gadallah M, Shabaan A. Astaxanthin attenuates cardiovascular dysfunction associated with deoxycorticosterone acetate-salt-induced hypertension in rats. Clin Exp Hypertens. 2022;44(4):382-395. doi:10.1080\/10641963.2022.2055764 \u003cbr\u003e\u003cbr\u003e4. Shatoor AS, Al Humayed S. Astaxanthin Ameliorates high-fat diet-induced cardiac damage and fibrosis by upregulating and activating SIRT1. Saudi J Biol Sci. 2021;28(12):7012-7021. doi:10.1016\/j.sjbs.2021.07.079 \u003cbr\u003e\u003cbr\u003e5. Sun K, Luo J, Jing X, et al. Astaxanthin protects against osteoarthritis via Nrf2: a guardian of cartilage homeostasis. Aging (Albany NY). 2019;11(22):10513-10531. doi:10.18632\/aging.102474 \u003cbr\u003e\u003cbr\u003e6. Sun K, Luo J, Jing X, et al. Astaxanthin protects against osteoarthritis via Nrf2: a guardian of cartilage homeostasis. Aging (Albany NY). 2019;11(22):10513-10531. doi:10.18632\/aging.102474\u003c\/p\u003e\n\u003c\/details\u003e\u003cfooter\u003e\n\u003cul\u003e\n\u003cli\u003eAstaxanthin is a carotenoid antioxidant that is primarily obtained through dietary sources such as microalgae and certain seafood like salmon and krill.\u003c\/li\u003e\n\u003cli\u003eAstaxanthin functions as an antioxidant to reduce levels of oxidative stress, a key contributor to cellular aging and declining healthspan.\u003c\/li\u003e\n\u003cli\u003eOxidative stress contributes to elevated inflammatory markers, cognitive decline, joint deterioration, vision decline, and increased risk of cardiovascular issues.\u003c\/li\u003e\n\u003cli\u003eStudies show that reducing oxidative stress with astaxanthin improves joint, brain, heart, and eye health.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/footer\u003e\u003cmain\u003e\n\u003ctable width=\"100%\" cellspacing=\"2\" cellpadding=\"0\" border=\"0\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003cth colspan=\"3\" style=\"font-size: 11pt; font-weight: bold;\" align=\"left\"\u003eSupplement Facts\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd colspan=\"3\" class=\"smalltext\"\u003eServing Size: 1 Capsule\u003cbr\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd colspan=\"3\" class=\"smalltext\"\u003eServings Per Container: 30\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd colspan=\"2\" class=\"smalltext\" style=\"font-weight: bold;\"\u003eAmount Per Serving\u003c\/td\u003e\n\u003ctd style=\"white-space: nowrap;\" class=\"smalltext\" align=\"right\"\u003e\u003cstrong\u003e%DV\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"smalltext\"\u003eAstaxanthin (\u003cem\u003eHaematococcus pluvialis \u003c\/em\u003emicroalgae extract)\u003c\/td\u003e\n\u003ctd class=\"smalltext\" style=\"white-space: nowrap;\" align=\"right\"\u003e12 mg\u003c\/td\u003e\n\u003ctd class=\"smalltext\" style=\"white-space: nowrap;\" align=\"right\"\u003e†\u003cbr\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd colspan=\"3\" class=\"smalltext\"\u003e† Daily Value (DV) not established\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003eREV.06.25\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eOTHER INGREDIENTS: \u003c\/strong\u003eHypromellose (capsule), microcrystalline cellulose, brown rice flour\u003cstrong\u003e.\u003c\/strong\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSUGGESTED DAILY USE:\u003c\/strong\u003e Take one (1) capsule per day, preferably with a meal.\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNOTE:\u003c\/strong\u003e Please consult your physician before use if you are pregnant or nursing, under the age of 18, or are undergoing treatment for a medical condition. Do not exceed the suggested use. \u003cstrong\u003eKEEP OUT OF REACH OF CHILDREN\u003c\/strong\u003e. Store in a cool and dry place.\u003cbr\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/main\u003e\n\u003cdiv class=\"summary\"\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eUnique Formulation. \u003c\/strong\u003eProHealth’s Astaxanthin is sourced from a type of algae known as haematococcus pluvialis, which synthesizes astaxanthin as a protective mechanism when it's exposed to environmental stress, such as UV radiation or nutrient depletion.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eEffective Dosing: \u003c\/strong\u003eProHealth's Astaxanthin contains a clinically effective dose of 12 mg of astaxanthin per serving, a dose that has proven to be safe and effective in human trials.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eQuality Manufacturing Practices.\u003c\/strong\u003e All of our products are manufactured in an FDA-registered, GMP-certified facility.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eThird-Party Tested in the USA.\u003c\/strong\u003e Every batch is third-party tested in US laboratories to ensure the highest quality, purity and potency. Certificates of Analysis are available.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e","brand":"ProHealth Wholesale","offers":[{"title":"Default Title","offer_id":49221443190944,"sku":"PH645","price":15.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0507\/7588\/3936\/files\/PH645_175ML_FRNT_600x600_e9bcb90f-5839-4c10-bfc3-08a9f1231641.png?v=1771890451"},{"product_id":"prohealth-sirtuin-6-activator-60-capsules-ph664","title":"Sirtuin 6 Activator - 60 capsules","description":"\u003cdiv class=\"product-benefits-copy\"\u003e\n\u003cp\u003e\u003cstrong style=\"font-size: 1.1em;\"\u003eSirtuin 6 Activator: Inspired by the Blue Zones \u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eActivates sirtuin 6 (SIRT6)\u003csup\u003e1,4,6,7*\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003cli\u003eProvides “Blue Zone” bioactives*\u003csup\u003e5,6 \u003c\/sup\u003e\n\u003c\/li\u003e\n\u003cli\u003eSupports multiple longevity pathways*\u003csup\u003e5 \u003c\/sup\u003e\n\u003c\/li\u003e\n\u003cli\u003eNeutralizes free radicals*\u003csup\u003e5,12\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003cli\u003eSupports a healthy immune system \u0026amp; inflammatory response* \u003csup\u003e8,5,9-11\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cspan style=\"color: #0000ff;\"\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0507\/7588\/3936\/files\/PH664_-_COA_Qalitex_LOT_A24L017_2025-02-11.pdf?v=1743025431\" rel=\"noopener noreferrer\" style=\"color: #0000ff;\" target=\"_blank\"\u003eView Certificate of Analysis \u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eNot all fucoidan is created equal. After three years of extensive research and testing, we've finally sourced an authentic \u003cem\u003eFucus vesiculosus\u003c\/em\u003e—a special type of seaweed renowned for its powerful fucoidan content and abundant marine polyphenols. This premium seaweed extract sets a new benchmark in longevity science.* \u003csup\u003e2,5,8,13,21,22,25\u003c\/sup\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong style=\"font-size: 1.1em;\"\u003eWhat Makes Ours Better?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eFucoidan-Rich Seaweed:\u003c\/strong\u003e We deliver pure, concentrated seaweed—not synthetic compounds or low-quality extracts—packed with fucoidan, a potent SIRT6 activator.*\u003csup\u003e21,22\u003c\/sup\u003e \u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLongevity Boost:\u003c\/strong\u003e Each serving provides a full 400mg dose of fucoidan, the scientifically-backed compound for healthy aging.*\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFull Spectrum Support:\u003c\/strong\u003e Our formula blends whole-plant seaweed powder with high-potency extracts, offering a more complete range of bioactive compounds to amplify fucoidan’s anti-aging potential.*\u003csup\u003e12,15\u003c\/sup\u003e\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMaximized Bioactivity:\u003c\/strong\u003e Unlike many seaweed extracts that lose potency through harsh processing, our fucoidan is gently extracted using a specialized water-based method, preserving its full molecular structure for optimal effectiveness.*\u003csup\u003e5\u003c\/sup\u003e\u003cbr\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong style=\"font-size: 1.1em;\"\u003eWhy Choose ProHealth?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eDoctor-Formulated:\u003c\/strong\u003e Developed by our in-house science team in collaboration with leading wellness experts to address the root causes of aging.*\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTriple Lab Tested:\u003c\/strong\u003e Subjected to three rounds of independent third-party lab testing to ensure unmatched potency and purity.\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFull Transparency:\u003c\/strong\u003e In an industry full of misleading claims, we publish our third-party lab results—so you always know exactly what’s in every bottle.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eManufactured in the USA:\u003c\/strong\u003e Made in FDA-regulated, GMP-certified facilities, adhering to the highest quality and safety standards.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003e100-Day Risk-Free Guarantee:\u003c\/strong\u003e We’re confident you’ll love our product. If you’re not satisfied, contact our Santa Barbara, CA office for a full refund within 100 days—no hassle, no questions asked.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong style=\"font-size: 1.1em;\"\u003eNot all fucoidan is created equal. \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eFor centuries, Japan—home to one of the world’s longest-living populations—has relied on seaweed as a dietary staple, prized for its powerful antioxidants and cellular-protective compounds. Research consistently links regular seaweed consumption to enhanced health and longevity, reinforcing its vital role in healthy aging.*\u003csup\u003e15\u003c\/sup\u003e\u003c\/p\u003e\nBuilding on this tradition, \u003cstrong\u003eSirtuin 6 Activator\u003c\/strong\u003e delivers fucoidan, one of seaweed’s most potent bioactive compounds. Naturally found in the cell walls of brown seaweed, fucoidan is clinically recognized for its ability to activate SIRT6, a key enzyme that supports healthy aging at the cellular level.*\u003csup\u003e1\u003c\/sup\u003e\n\u003cp\u003eBy activating SIRT6, this fucoidan-rich formula goes beyond simple antioxidant support to revitalize cellular health at its core. Research shows that increased SIRT6 activity can aid in DNA repair, boost genomic stability, and support a healthy systemic inflammatory response—processes linked to longevity in Blue Zone populations.*\u003csup\u003e5,8,9,12,14,16\u003c\/sup\u003e\u003c\/p\u003e\nEmerging studies further suggest that higher SIRT6 activity correlates with longer lifespans in multiple animal species. Scientists are now exploring its potential for brain aging, heart health, and overall longevity, with human trials underway to further uncover its impact on healthy aging.*\u003csup\u003e20,26-28\u003c\/sup\u003e\n\u003cp\u003e\u003cstrong style=\"font-size: 1.1em;\"\u003e\u003cbr\u003eSirtuin 6 Activator: Inspired by the Blue Zones \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eAging is associated with cellular changes, including DNA damage, inflammation, and metabolic shifts, all of which have been studied in relation to SIRT6’s biological functions. Research suggests that SIRT6 plays a role in key cellular processes that support overall health.*\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eSupports DNA Repair\u003c\/strong\u003e – SIRT6 stabilizes the genome by repairing double-strand breaks and maintaining telomere integrity, reducing genetic instability, a major hallmark of aging.*\u003csup\u003e6\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eInfluences Metabolic Balance\u003c\/strong\u003e – SIRT6 shifts cells away from inefficient sugar metabolism and toward fat oxidation, mimicking the anti-aging effects of caloric restriction.*\u003csup\u003e17\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eClears Senescent Cells\u003c\/strong\u003e – Fucoidan acts as a potential senolytic, helping the body remove dysfunctional cells that drive aging.*\u003csup\u003e4,13,19\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eProtects Mitochondria\u003c\/strong\u003e – SIRT6 supports healthy cellular energy production, safeguarding from oxidative stress so cells can generate energy efficiently.*\u003csup\u003e5\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong style=\"font-size: 1.1em;\"\u003eNeutralizes Free Radicals* \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eOxidative stress occurs when free radicals accumulate and damage cells, proteins, and DNA—a primary driver of aging. ProHealth Sirtuin 6 Activator combats oxidative damage through multiple pathways:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eDirectly Scavenges Free Radicals\u003c\/strong\u003e – Fucoidan’s unique sulfated polysaccharide structure binds to and neutralizes reactive oxygen species (ROS) before they can harm cells.*\u003csup\u003e12\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eProvides Antioxidant Support\u003c\/strong\u003e – This formula combines fucoidan with polyphloroglucinols, marine polyphenols that strengthen cellular defenses against oxidative damage.*\u003csup\u003e5\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eEnhances Cellular Antioxidant Pathways\u003c\/strong\u003e – By enhancing glutathione and superoxide dismutase (SOD) levels, SIRT6 supports the body’s natural ability to maintain oxidative homeostasis.*\u003csup\u003e12\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong style=\"font-size: 1.1em;\"\u003eSupports a Healthy Immune System \u0026amp; Inflammatory Response* \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eHealthy immune system and inflammatory responses are essential for long-term health and longevity. Research suggests that fucoidan and SIRT6 may help support immune function and inflammation balance through multiple pathways:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eSupports Immune Cell Activity\u003c\/strong\u003e – Fucoidan supports the activity of macrophages, natural killer (NK) cells, and lymphocytes, helping to maintain a robust immune system and clear damaged cells.*\u003csup\u003e5,8,10\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHelps Maintain a Healthy Inflammatory Response\u003c\/strong\u003e – SIRT6 influences cytokine activity and inflammatory response mechanisms, helping to support healthy inflammation for optimal aging.* \u003csup\u003e5,8,9\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eEnhances Gut-Immune Function\u003c\/strong\u003e – Fucoidan supports a healthy gut microbiome, which is closely linked to immune and inflammatory balance.*\u003csup\u003e11\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eOrder now and join the 200,000+ people who trust ProHealth Sirtuin 6 Activator for their cellular health!\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong style=\"font-size: 1.1em;\"\u003eIngredients:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eBrown Seaweed\u003c\/strong\u003e \u003cem\u003e(Fucus vesiculosus)\u003c\/em\u003e: A rich source of fucoidan, a bioactive polysaccharide recognized for supporting cellular health and activating SIRT6, the longevity enzyme.*\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eReferences:\u003c\/strong\u003e\u003c\/p\u003e\n\u003col\u003e\n\u003cli\u003eRahnasto-Rilla M et al. \u003cem\u003eMar Drugs.\u003c\/em\u003e 2017;15(6):190.\u003c\/li\u003e\n\u003cli\u003eKawaguchi T et al. \u003cem\u003eInt J Oncol\u003c\/em\u003e. 2015;46(5):2216-2222.\u003c\/li\u003e\n\u003cli\u003eYu W et al. Mol Nutr Food Res. 2017;61(10):1700136.\u003c\/li\u003e\n\u003cli\u003eCao L et al. \u003cem\u003eMar Drugs\u003c\/em\u003e. 2020;18(11):564.\u003c\/li\u003e\n\u003cli\u003eLi B et al. \u003cem\u003eMolecules\u003c\/em\u003e. 2008;13(8):1671-1695.\u003c\/li\u003e\n\u003cli\u003eLópez-Otín C et al. \u003cem\u003eCell\u003c\/em\u003e. 2023;186(2):243-278.\u003c\/li\u003e\n\u003cli\u003eIso H and Kubota Y. \u003cem\u003eAsian Pac J Cancer Prev\u003c\/em\u003e. 2007;8 Suppl:35-80.\u003c\/li\u003e\n\u003cli\u003eJayawardena TU et al. \u003cem\u003eMar Drugs\u003c\/em\u003e. 2022;20(12):755.\u003c\/li\u003e\n\u003cli\u003eApostolova E et al. \u003cem\u003ePolymers\u003c\/em\u003e. 2020;12(10):2338.\u003c\/li\u003e\n\u003cli\u003eBogolitsyn K et al. \u003cem\u003ePlant Foods Hum Nutr\u003c\/em\u003e. 2024;79(2):511-517.\u003c\/li\u003e\n\u003cli\u003eLuthuli S et al. \u003cem\u003eMar Drugs\u003c\/em\u003e. 2019;17(9):487.\u003c\/li\u003e\n\u003cli\u003eCatarino MD et al. \u003cem\u003eMar Drugs\u003c\/em\u003e. 2018;16(8):249.\u003c\/li\u003e\n\u003cli\u003eZhang L et al. \u003cem\u003eInnov Aging\u003c\/em\u003e. 2022;6(Suppl 1):130.\u003c\/li\u003e\n\u003cli\u003eMyers S et al. \u003cem\u003eBiol Targets Ther\u003c\/em\u003e. 2011;45.\u003c\/li\u003e\n\u003cli\u003eMyers S. \u003cem\u003eBiol Targets Ther\u003c\/em\u003e. 2010;33.\u003c\/li\u003e\n\u003cli\u003eLi X et al. \u003cem\u003eFront Cell Dev Biol\u003c\/em\u003e. 2021;9:641315.\u003c\/li\u003e\n\u003cli\u003eZhang N et al. \u003cem\u003eCell Cycle.\u003c\/em\u003e 2016;15(7):1009-1018.\u003c\/li\u003e\n\u003cli\u003eChilton WL et al. \u003cem\u003ePLoS ONE\u003c\/em\u003e. 2014;9(4):e92088.\u003c\/li\u003e\n\u003cli\u003eAkter R et al. \u003cem\u003eInt J Mol Sci\u003c\/em\u003e. 2021;22(8):4180.\u003c\/li\u003e\n\u003cli\u003eZhang L et al. \u003cem\u003eInnov Aging\u003c\/em\u003e. 2022;6(Suppl 1):130.\u003c\/li\u003e\n\u003cli\u003eGorbunova V. \u003cem\u003eInnov Aging\u003c\/em\u003e. 2019;3(Suppl 1):S8.\u003c\/li\u003e\n\u003cli\u003eKawamura A et al. \u003cem\u003eMar Drugs\u003c\/em\u003e. 2021;19(8):452.\u003c\/li\u003e\n\u003cli\u003eWillcox DC et al. \u003cem\u003eAnn NY Acad Sci\u003c\/em\u003e. 2009;1173:126-138.\u003c\/li\u003e\n\u003cli\u003eBuettner D. \u003cem\u003eNatl Geogr Books\u003c\/em\u003e. 2015.\u003c\/li\u003e\n\u003cli\u003eKorotkov A et al. \u003cem\u003eTrends Cell Biol\u003c\/em\u003e. 2021;31(12):994-1006.\u003c\/li\u003e\n\u003cli\u003eZhang L et al. \u003cem\u003eOxid Med Cell Longev\u003c\/em\u003e. 2019;2019:8918914.\u003c\/li\u003e\n\u003cli\u003eYang J et al. \u003cem\u003eInt J Biol Macromol.\u003c\/em\u003e 2024;277(Pt 3):134397.\u003c\/li\u003e\n\u003cli\u003eWang K et al. \u003cem\u003eTher Adv Chronic Dis\u003c\/em\u003e. 2022;13:20406223221076891.\u003c\/li\u003e\n\u003c\/ol\u003e\n\n\u003c\/div\u003e\n\u003cdiv class=\"product-label-copy\"\u003e\n\u003ctable width=\"100%\" cellspacing=\"2\" cellpadding=\"0\" border=\"0\" style=\"height: 243.333px;\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 29.9667px;\"\u003e\n\u003cth style=\"font-size: 11pt; font-weight: bold; height: 29.9667px;\" colspan=\"3\" align=\"left\"\u003eSupplement Facts\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 29.0333px;\"\u003e\n\u003ctd class=\"smalltext\" colspan=\"3\" style=\"height: 29.0333px;\"\u003eServing Size: 1 Capsule\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 29.0333px;\"\u003e\n\u003ctd class=\"smalltext\" colspan=\"3\" style=\"height: 29.0333px;\"\u003eServings Per Container: 60\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 29.0333px;\"\u003e\n\u003ctd style=\"font-weight: bold; height: 29.0333px;\" class=\"smalltext\" colspan=\"2\"\u003eAmount Per Serving\u003c\/td\u003e\n\u003ctd style=\"white-space: nowrap; height: 29.0333px;\" class=\"smalltext\" align=\"right\"\u003e\u003cstrong\u003e%DV\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 48.6333px;\"\u003e\n\u003ctd class=\"smalltext\" style=\"height: 48.6333px;\"\u003eFucoidan (from Bladderwrack [\u003cem\u003eFucus vesiculosus\u003c\/em\u003e] Whole Plant Extract and Brown Seaweed [\u003cem\u003eUndaria pinnatifida\u003c\/em\u003e] Whole Plant Extract)\u003c\/td\u003e\n\u003ctd style=\"white-space: nowrap; height: 48.6333px;\" class=\"smalltext\" align=\"right\"\u003e400 mg\u003c\/td\u003e\n\u003ctd style=\"white-space: nowrap; height: 48.6333px;\" class=\"smalltext\" align=\"right\"\u003e†\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 48.6333px;\"\u003e\n\u003ctd class=\"smalltext\" style=\"height: 48.6333px;\"\u003eBladderwrack (\u003cem\u003eFucus vesiculosus\u003c\/em\u003e) Whole Plant Powder\u003c\/td\u003e\n\u003ctd style=\"white-space: nowrap; height: 48.6333px;\" class=\"smalltext\" align=\"right\"\u003e100 mg\u003c\/td\u003e\n\u003ctd style=\"white-space: nowrap; height: 48.6333px;\" class=\"smalltext\" align=\"right\"\u003e†\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 29px;\"\u003e\n\u003ctd class=\"smalltext\" colspan=\"3\" style=\"height: 29px;\"\u003e† Daily Value (DV) not established\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\nREV.10.24\u003cbr\u003e\u003cbr\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eOTHER INGREDIENTS: \u003c\/strong\u003eVegetable cellulose (capsule), microcrystalline cellulose, bamboo silica.\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eMay contain\u003c\/strong\u003e traces of fish and\/or shellfish residue.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSUGGESTED DAILY USE: \u003c\/strong\u003eTake one (1) capsule daily, or as directed by your healthcare professional.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAUTION: \u003c\/strong\u003eFor use by healthy adults only. Please consult your physician before use if you are pregnant or nursing, under the age of 18, or are undergoing treatment for a medical condition. Do not exceed the suggested use. \u003cstrong\u003eKEEP OUT OF REACH OF CHILDREN.\u003c\/strong\u003e Store in a cool and dry place after opening.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e","brand":"ProHealth Wholesale","offers":[{"title":"Default Title","offer_id":52292644536480,"sku":"PH664","price":79.95,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0507\/7588\/3936\/files\/PH664_100CC_FRNT_600x600-Rev1024.png?v=1740437705"},{"product_id":"prohealth-nicotinamide-riboside-pterostilbene-30-capsules-ph710","title":"Nicotinamide Riboside + Pterostilbene - 30 capsules","description":"\u003cdiv class=\"product-benefits-copy\"\u003e\n\u003cp\u003eNicotinamide riboside (NR), an advanced form of vitamin B3 (niacin), has proven to be one of the most promising supplements to promote longevity and healthy aging. By functioning as an NAD+ precursor, NR has been proven to significantly increase NAD+ levels in the body, thus promoting heart, brain, metabolic, and cellular health. Pterostilbene is a powerful antioxidant compound that has been shown to activate sirtuins (longevity genes), amplifying the longevity-promoting effects of NR.\u003c\/p\u003e\n\u003ch2\u003eNR + Pterostilbene\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eSupports longevity by increasing NAD+ levels and activating sirtuins\u003c\/li\u003e\n\u003cli\u003eEnhances cellular health by promoting DNA repair and reducing oxidative stress\u003c\/li\u003e\n\u003cli\u003ePromotes heart health by supporting healthy blood flow\u003c\/li\u003e\n\u003cli\u003eProtects the brain from age-related functional decline\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cspan style=\"color: #0000ff;\"\u003e\u003ca style=\"color: #0000ff;\" href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0507\/7588\/3936\/files\/PH710_-_COA_Brighton_LOT_26033_2025.09.10_2.pdf?v=1757958063\" target=\"_blank\"\u003eView Certificate of Analysis »\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003ch3\u003eResearch-Supported Benefits:\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003ePromotes Longevity. \u003c\/strong\u003eNicotinamide Riboside promotes longevity by increasing levels of NAD+ in the body. NAD+ levels decline with age, contributing to accelerated cellular aging and health decline. Research shows that increasing NAD+ levels in aged animals extends lifespan. (1) Pterostilbene supports longevity by activating sirtuins, which are commonly referred to as \"longevity genes\". Animal studies show that activating sirtuins extends lifespan and healthspan. (2)\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSupports Cellular Health.\u003c\/strong\u003e By increasing NAD+ levels, NR aids in facilitating DNA repair. (3) DNA damage is associated with decreased longevity and increased risk for age-related health decline, highlighting the importance of the DNA repair process. Due to its antioxidant potential, pterostilbene offers additional protection for cellular health by reducing oxidative damage, a key contributor to cellular aging. (4)\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eEnhances Heart Health. \u003c\/strong\u003eResearch shows that NR enhances heart health by reducing stiffness of the arteries and supporting healthy blood flow. (5) Aortic stiffness contributes to blood pressure dysregulation and increased cardiac risk, making the reduction of aortic stiffness critical to maintaining heart health. Animal studies also show pterostilbene exhibits cardio-protective effects by reducing oxidative stress of heart tissue. (6)\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eProtects Against Cognitive Decline. \u003c\/strong\u003eNAD+ is critical to maintaining mitochondrial health of brain cells. A decline of NAD+ levels research suggests that reduced NAD+ levels contribute to many of the hallmarks of brain aging. By increasing NAD+ levels and aiding in the regulation of inflammatory levels, Nicotinamide Riboside shows promise in supporting healthy brain aging and cognitive function. (7) Pterostilbene further supports healthy brain aging by activating sirt-1 and improving synaptic plasticity, a vital biological process related to memory and learning. (8)\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eReferences:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e1. Fang EF, Lautrup S, Hou Y, et al. NAD+ in Aging: Molecular Mechanisms and Translational Implications. Trends Mol Med. 2017;23(10):899-916. doi:10.1016\/j.molmed.2017.08.001 \u003cbr\u003e\u003cbr\u003e2. Grabowska W, Sikora E, Bielak-Zmijewska A. Sirtuins, a promising target in slowing down the ageing process. Biogerontology. 2017;18(4):447-476. doi:10.1007\/s10522-017-9685-9 \u003cbr\u003e\u003cbr\u003e3. Wilk A, Hayat F, Cunningham R, et al. Extracellular NAD+ enhances PARP-dependent DNA repair capacity independently of CD73 activity. Sci Rep. 2020;10(1):651. Published 2020 Jan 20. doi:10.1038\/s41598-020-57506-9 \u003cbr\u003e\u003cbr\u003e4. Nagarajan S, Mohandas S, Ganesan K, Xu B, Ramkumar KM. New Insights into Dietary Pterostilbene: Sources, Metabolism, and Health Promotion Effects. Molecules. 2022;27(19):6316. Published 2022 Sep 25. doi:10.3390\/molecules27196316 \u003cbr\u003e\u003cbr\u003e5. Martens CR, Denman BA, Mazzo MR, et al. Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults. Nat Commun. 2018;9(1):1286. Published 2018 Mar 29. doi:10.1038\/s41467-018-03421-7 \u003cbr\u003e\u003cbr\u003e6. Kosuru R, Kandula V, Rai U, Prakash S, Xia Z, Singh S. Pterostilbene Decreases Cardiac Oxidative Stress and Inflammation via Activation of AMPK\/Nrf2\/HO-1 Pathway in Fructose-Fed Diabetic Rats. Cardiovasc Drugs Ther. 2018;32(2):147-163. doi:10.1007\/s10557-018-6780-3 \u003cbr\u003e\u003cbr\u003e7. Lee HJ, Yang SJ. Supplementation with Nicotinamide Riboside Reduces Brain Inflammation and Improves Cognitive Function in Diabetic Mice. Int J Mol Sci. 2019;20(17):4196. Published 2019 Aug 27. doi:10.3390\/ijms20174196 \u003cbr\u003e\u003cbr\u003e8. Michán S, Li Y, Chou MM, et al. SIRT1 is essential for normal cognitive function and synaptic plasticity. J Neurosci. 2010;30(29):9695-9707. doi:10.1523\/JNEUROSCI.0027-10.2010 \u003cbr\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"product-how-it-work-copy\"\u003e\n\u003cul\u003e\n\u003cli\u003eNicotinamide Riboside (NR) and pterostilbene represent a powerful 1-2 combo in longevity supplements due to their respective ability to increase NAD+ levels and activate sirtuins.\u003c\/li\u003e\n\u003cli\u003eNAD+ functions as the fuel for sirtuins, which then activate defensive enzymes to fight aging.\u003c\/li\u003e\n\u003cli\u003eNAD+ levels decline with age, with an estimated 50% decline in NAD+ levels by age 50\u003c\/li\u003e\n\u003cli\u003eThis decline in NAD+ production reduces the ability of sirtuins to perform their anti-aging repair effects.\u003c\/li\u003e\n\u003cli\u003eNR and pterostilbene further support healthy aging by improving mitochondrial health, supporting cardiovascular function, and protecting against symptoms of brain aging.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"product-label-copy\"\u003e\n\u003ctable width=\"100%\" cellspacing=\"2\" cellpadding=\"0\" border=\"0\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003cth colspan=\"3\" style=\"font-size: 11pt; font-weight: bold;\" align=\"left\"\u003eSupplement Facts\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd colspan=\"3\" class=\"smalltext\"\u003eServing Size: 1 Capsule\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd colspan=\"3\" class=\"smalltext\"\u003eServings Per Container: 30\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd colspan=\"2\" class=\"smalltext\" style=\"font-weight: bold;\"\u003eAmount Per Serving\u003c\/td\u003e\n\u003ctd style=\"white-space: nowrap;\" class=\"smalltext\" align=\"right\"\u003e\u003cstrong\u003e%DV\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"smalltext\"\u003eNR (as Nicotinamide Riboside \u003cbr\u003e  Hydrogen Malate)\u003c\/td\u003e\n\u003ctd class=\"smalltext\" style=\"white-space: nowrap;\" align=\"right\"\u003e250 mg\u003c\/td\u003e\n\u003ctd class=\"smalltext\" style=\"white-space: nowrap;\" align=\"right\"\u003e†\u003cbr\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"smalltext\"\u003ePterostilbene\u003c\/td\u003e\n\u003ctd class=\"smalltext\" style=\"white-space: nowrap;\" align=\"right\"\u003e40 mg\u003cbr\u003e\n\u003c\/td\u003e\n\u003ctd class=\"smalltext\" style=\"white-space: nowrap;\" align=\"right\"\u003e†\u003cbr\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd colspan=\"3\" class=\"smalltext\"\u003e† Daily Value (DV) not established\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\nREV.07.25\u003cbr\u003e\u003cbr\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eOTHER INGREDIENTS: \u003c\/strong\u003eHypromellose (capsule), rice flour.\u003cstrong\u003e \u003c\/strong\u003e\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSUGGESTED DAILY USE:\u003c\/strong\u003e Take one (1) capsule per day, with or without food, preferably in the morning.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAUTION:\u003c\/strong\u003e For use by healthy adults only. Please consult your physician before use if you are pregnant or nursing, under the age of 18, or are undergoing treatment for a medical condition. Do not exceed the suggested use. \u003cstrong\u003eKEEP OUT OF REACH OF CHILDREN\u003c\/strong\u003e. Store in a cool and dry place after opening.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"summary-copy\"\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eUnique Formulation. \u003c\/strong\u003eProHealth’s NR + Pterostilbene was specifically formulated to reduce symptoms of age-related health decline. By combining these two complimentary ingredients, this formula amplifies the effect of either ingredient if taken alone.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eQuality Manufacturing Practices.\u003c\/strong\u003e All of our products are manufactured in an FDA-registered, GMP-certified facility.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eThird-Party Tested in the USA.\u003c\/strong\u003e Every batch is third-party tested in US laboratories to ensure the highest quality, purity and potency. Certificates of Analysis are available.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e","brand":"ProHealth Wholesale","offers":[{"title":"Default Title","offer_id":52366405468320,"sku":"PH710","price":29.95,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0507\/7588\/3936\/files\/PH710_175MCC_FRNT_600x600_REV1124.png?v=1744215932"},{"product_id":"prohealth-full-spectrum-urolithin-a-60-capsules-ph694","title":"Full Spectrum Urolithin A - 60 capsules","description":"\u003cdiv class=\"product-benefits-copy\"\u003e\n\u003cp\u003e\u003cstrong style=\"font-size: 1.1em;\"\u003eUrolithin A: The Gold Standard Longevity Molecule \u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eBoost Urolithin A levels*\u003csup\u003e1-2\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003cli\u003eDiminish oxidative stress*\u003csup\u003e3-5\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003cli\u003eEnhance cellular health*\u003csup\u003e1,6-7\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003cli\u003eSupport youthful aging and longevity*\u003csup\u003e1,3,7-11\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cspan style=\"color: #0000ff;\"\u003e\u003ca style=\"color: #0000ff;\" rel=\"noopener noreferrer\" href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0507\/7588\/3936\/files\/PH694_-_COA_Brighton_LOT_A26H041_2026.10.21_2.pdf?v=1792681465\" target=\"_blank\"\u003eView Certificate of Analysis \u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eOur full spectrum formula delivers a clinically supported dose of Urolithin A, paired with its natural precursors in polyphenol-rich extracts from pomegranate and red muscadine grapes. Urolithin A directly supports levels of this key longevity molecule, while the fruits enhance gut metabolism to further amplify Urolithin A production—providing a powerful “double boost” to unlock its full potential.* \u003csup\u003e1-3,12-13\u003c\/sup\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong style=\"font-size: 1.1em;\"\u003eWhat Makes Ours Better?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eFull Spectrum Blend:\u003c\/strong\u003e Combines pure Urolithin A with powerful fruit extracts that help boost Urolithin A production in your body.*\u003csup\u003e1-2\u003c\/sup\u003e \u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBio-Identical Support:\u003c\/strong\u003e Urolithin A is a naturally occurring “postbiotic” produced by your gut during the digestion of polyphenols (ellagic acid and ellagitannins) found in foods.*\u003csup\u003e10\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eGut-Boosting Polyphenols:\u003c\/strong\u003e These prebiotic-like compounds nourish your gut microbiome, promoting the growth of Urolithin A-producing bacteria.*\u003csup\u003e12-13\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBridge the Microbiome Gap:\u003c\/strong\u003e Not everyone has the gut bacteria needed to produce Urolithin A, but our unique full-spectrum formula ensures that you—along with everyone else—can benefit from its powerful effects.*\u003csup\u003e8-9\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong style=\"font-size: 1.1em;\"\u003eWhy Choose ProHealth?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eDoctor-Formulated:\u003c\/strong\u003e Developed by our in-house science team in collaboration with leading wellness experts to address the root causes of aging.*\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTriple Lab Tested:\u003c\/strong\u003e Rigorously tested three times by independent third-party labs to guarantee unmatched potency and purity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFull Transparency:\u003c\/strong\u003e In an industry full of misleading claims, we publish our third-party lab results—so you always know exactly what’s in every bottle.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eManufactured in the USA:\u003c\/strong\u003e Since 1988, we’ve proudly produced our supplements in FDA-regulated, GMP-certified facilities, ensuring the highest quality and safety standards.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003e100-Day Risk-Free Guarantee:\u003c\/strong\u003e We stand behind our products. If you’re not completely satisfied, contact our Santa Barbara, CA office for a full refund—no hassle, no questions asked.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eUrolithin A is a bioavailable metabolite produced in the colon when gut microbiota metabolizes polyphenols (ellagitannins and ellagic acid) from a healthy diet. As we age, our ability to convert these polyphenols into Urolithin A declines, influenced by factors like gut microbiome composition, diet, health, and genetics. A significant portion of the population struggles to efficiently convert polyphenols into Urolithin A.\u003csup\u003e2,8-10\u003c\/sup\u003e\u003cbr\u003e\u003cbr\u003eSupplemental Urolithin A bypasses these challenges, providing benefits regardless of age, microbiome, or genetics. It enters the bloodstream and reaches tissues and cells that need it most, activating key pathways for healthy aging.*\u003csup\u003e2,9\u003c\/sup\u003e \u003cbr\u003e\u003cbr\u003eWhile supplemental Urolithin A provides direct systemic support, diet-derived precursors primarily benefit the gut microbiome. Research shows that dietary polyphenols can promote intestinal wellness by supporting Urolithin A-producing bacteria, leading to increased Urolithin A production. To optimize these effects, we’ve incorporated concentrated polyphenol extracts into our full-spectrum formula.*\u003csup\u003e12-13\u003cbr\u003e\u003cbr\u003e\u003c\/sup\u003e\u003cstrong style=\"font-size: 1.1em;\"\u003eTarget Core Longevity Pathways* \u003cbr\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eWhether sourced from supplementation or naturally produced in the gut, Urolithin A efficiently enters the bloodstream and reaches cells throughout the body, where it influences multiple metabolic pathways linked to longevity:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eAMPK:\u003c\/strong\u003e Fuels energy production and metabolism.*\u003csup\u003e3\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003emTOR:\u003c\/strong\u003e Supports cell repair and regeneration.*\u003csup\u003e1,3,10\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSIRT1:\u003c\/strong\u003e Protects DNA and combats cellular senescence.*\u003csup\u003e1-2,14\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNF-kB:\u003c\/strong\u003e Impacts inflammation, a key factor in aging.*\u003csup\u003e1,3,8-10\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eUrolithin A has quickly become one of the most exciting longevity molecules, targeting aging at its cellular core while activating multiple longevity pathways. Clinically validated, it stands as one of the most promising compounds for extending healthspan and preserving vitality throughout the aging process.*\u003c\/p\u003e\n\u003cp\u003e\u003cstrong style=\"font-size: 1.1em;\"\u003eFeel the Difference with ProHealth Full Spectrum Urolithin A \u003cbr\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eElevate your longevity with a dual boost of Urolithin A and its natural precursors. Expertly formulated by doctors, this advanced formula is designed to maximize the benefits of Urolithin A, delivering full-spectrum support for your health, vitality, and longevity.*\u003csup\u003e1-3,12,13\u003c\/sup\u003e\u003cstrong\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eOrder now and join the 200,000+ people who trust ProHealth Full Spectrum Urolithin A for their cellular health!\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong style=\"font-size: 1.1em;\"\u003eIngredients:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eUrolithin A:\u003c\/strong\u003e A powerful gut-derived compound produced by the microbiome when it metabolizes ellagic acid from foods like pomegranates, berries, and walnuts.*\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePomegranate Extract:\u003c\/strong\u003e A potent superfruit and key precursor to Urolithin A, standardized to 30% punicalagins, the primary polyphenolic compound responsible for pomegranate’s health benefits.*\u003csup\u003e15-16\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eRed Muscadine Grape Extract:\u003c\/strong\u003e A nutrient-dense fruit known for its abundance of polyphenolic compounds such as resveratrol and ellagic acid.*\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eReferences:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003csup\u003e1 \u003c\/sup\u003eLiu Y et al. \u003cem\u003eNutrients\u003c\/em\u003e. 2024;16(19):3305. \u003cbr\u003e\u003csup\u003e2 \u003c\/sup\u003eGarcía-Villalba R et al. \u003cem\u003eMol Aspects Med.\u003c\/em\u003e 2023;89:101109.\u003cbr\u003e\u003csup\u003e3 \u003c\/sup\u003eZhao H et al. \u003cem\u003eNutrients.\u003c\/em\u003e 2023;15(20):4441.\u003cbr\u003e\u003csup\u003e4 \u003c\/sup\u003eZhao et al. \u003cem\u003eJ Int Soc Sports Nutr.\u003c\/em\u003e 2024;21(1):2419388.\u003cbr\u003e\u003csup\u003e5 \u003c\/sup\u003eVerdú D et al. \u003cem\u003eAntioxidants (Basel)\u003c\/em\u003e. 2023;12(11):1991. \u003cbr\u003e\u003csup\u003e6 \u003c\/sup\u003eAndreux PA et al. \u003cem\u003eNat Metab.\u003c\/em\u003e 2019;1(6):595-603.  \u003cbr\u003e\u003csup\u003e7 \u003c\/sup\u003eGarcía-Villalba R et al. \u003cem\u003eMol Aspects Med.\u003c\/em\u003e 2023;89:101109. \u003cbr\u003e\u003csup\u003e8 \u003c\/sup\u003eD’Amico D et al. \u003cem\u003eTrends Mol Med\u003c\/em\u003e. 2021;27(7):687-699. \u003cbr\u003e\u003csup\u003e9 \u003c\/sup\u003eKuerec AH et al. \u003cem\u003eAgeing Res Rev.\u003c\/em\u003e 2024;100:102406.\u003cbr\u003e\u003csup\u003e10 \u003c\/sup\u003eShetty SS et al. Beni-Suef Univ J Basic Appl Sci. 2024;13(1):31.\u003cbr\u003e\u003csup\u003e11 \u003c\/sup\u003eKubota D et al. \u003cem\u003eNutrients.\u003c\/em\u003e 2024;16(19):3369.  \u003cbr\u003e\u003csup\u003e12 \u003c\/sup\u003eChen P et al. \u003cem\u003eJ Integr Neurosci.\u003c\/em\u003e 2023;22(5):113. \u003cbr\u003e\u003csup\u003e13 \u003c\/sup\u003eAlves-Santos AM et al. \u003cem\u003eJ Funct Foods.\u003c\/em\u003e 2020;74:104169.\u003cbr\u003e\u003csup\u003e14 \u003c\/sup\u003eShi PZ et al. World J Stem Cells. 2021;13(12):1928-1946\u003cbr\u003e\u003csup\u003e15 \u003c\/sup\u003eStockton A. \u003cem\u003eEC Nutrition.\u003c\/em\u003e 2015;2(4):396-411. \u003cbr\u003e\u003csup\u003e16 \u003c\/sup\u003eStockton A et al. \u003cem\u003eJ Nutr Sci.\u003c\/em\u003e 2017;6:e39.\u003c\/p\u003e\n\u003cstrong\u003e\u003cstrong\u003e\u003c\/strong\u003e \u003c\/strong\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"product-label-copy\"\u003e\n\u003ctable width=\"100%\" cellspacing=\"2\" cellpadding=\"0\" border=\"0\" style=\"height: 243.333px;\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 29.9667px;\"\u003e\n\u003cth style=\"font-size: 11pt; font-weight: bold; height: 29.9667px;\" colspan=\"3\" align=\"left\"\u003eSupplement Facts\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 29.0333px;\"\u003e\n\u003ctd class=\"smalltext\" colspan=\"3\" style=\"height: 29.0333px;\"\u003eServing Size: 2 Capsules\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 29.0333px;\"\u003e\n\u003ctd class=\"smalltext\" colspan=\"3\" style=\"height: 29.0333px;\"\u003eServings Per Container: 30\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 29.0333px;\"\u003e\n\u003ctd style=\"font-weight: bold; height: 29.0333px;\" class=\"smalltext\" colspan=\"2\"\u003eAmount Per Serving\u003c\/td\u003e\n\u003ctd style=\"white-space: nowrap; height: 29.0333px;\" class=\"smalltext\" align=\"right\"\u003e\u003cstrong\u003e%DV\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 48.6333px;\"\u003e\n\u003ctd class=\"smalltext\" style=\"height: 48.6333px;\"\u003eStanYouth® Urolithin A\u003c\/td\u003e\n\u003ctd style=\"white-space: nowrap; height: 48.6333px;\" class=\"smalltext\" align=\"right\"\u003e500 mg\u003c\/td\u003e\n\u003ctd style=\"white-space: nowrap; height: 48.6333px;\" class=\"smalltext\" align=\"right\"\u003e†\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 48.6333px;\"\u003e\n\u003ctd class=\"smalltext\" style=\"height: 48.6333px;\"\u003ePomanox® Pomegranate Fruit\u003cbr\u003e  Extract (30% punicalagins)\u003c\/td\u003e\n\u003ctd style=\"white-space: nowrap; height: 48.6333px;\" class=\"smalltext\" align=\"right\"\u003e250 mg\u003c\/td\u003e\n\u003ctd style=\"white-space: nowrap; height: 48.6333px;\" class=\"smalltext\" align=\"right\"\u003e†\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 48.6333px;\"\u003e\n\u003ctd class=\"smalltext\" style=\"height: 48.6333px;\"\u003eMuscadine Grape Skin and\u003cbr\u003e  Seed Extract\u003c\/td\u003e\n\u003ctd style=\"white-space: nowrap; height: 48.6333px;\" class=\"smalltext\" align=\"right\"\u003e100 mg\u003c\/td\u003e\n\u003ctd style=\"white-space: nowrap; height: 48.6333px;\" class=\"smalltext\" align=\"right\"\u003e†\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 29px;\"\u003e\n\u003ctd class=\"smalltext\" colspan=\"3\" style=\"height: 29px;\"\u003e† Daily Value (DV) not established\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\nREV.11.25\u003cbr\u003e\u003cbr\u003eStanYouth® is a registered trademark of Bonerge Lifescience Corp. Pomanox® is a registered trademark of Euromed S.A.\u003cbr\u003e\u003cbr\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eOTHER INGREDIENTS: \u003c\/strong\u003eMicrocrystalline cellulose, hypromellose (capsule), bamboo extract.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSUGGESTED DAILY USE: \u003c\/strong\u003eTake two (2) capsules per day, preferably with food.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAUTION: \u003c\/strong\u003eFor use by healthy adults only. Please consult your physician before use if you are pregnant or nursing, under the age of 18, or are undergoing treatment for a medical condition. Do not exceed the suggested use. \u003cstrong\u003eKEEP OUT OF REACH OF CHILDREN.\u003c\/strong\u003e Store in a cool and dry place after opening.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e","brand":"ProHealth Wholesale","offers":[{"title":"Default Title","offer_id":52380263415968,"sku":"PH694","price":79.95,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0507\/7588\/3936\/files\/PH694_175CC_FRNT_600x600_REV-0125.png?v=1743542451"},{"product_id":"prohealth-sirtuin-1-activator-60-capsules-ph665","title":"Sirtuin 1 Activator - 60 capsules","description":"\u003cdiv class=\"product-benefits-copy\"\u003e\n\u003cp\u003e\u003cstrong style=\"font-size: 1.1em;\"\u003eSwitch On the Longevity Gene\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eActivates and supports SIRT1*\u003csup\u003e1-7\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003cli\u003ePromotes healthy aging at the cellular level*\u003csup\u003e2,3,8-11\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003cli\u003eStrengthens the body’s antioxidant network*\u003csup\u003e12\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003cli\u003eHelps maintain metabolic and inflammatory health*\u003csup\u003e13\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003cli\u003eBoosts mitochondrial biogenesis and energy output*\u003csup\u003e1,3\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cspan style=\"color: #0000ff;\"\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0507\/7588\/3936\/files\/PH665_-_COA_Brighton_LOT_26058_2025-11-11_2.pdf?v=1764179037\" rel=\"noopener noreferrer\" style=\"color: #0000ff;\" target=\"_blank\"\u003eView Certificate of Analysis\u003c\/a\u003e\u003cbr\u003e\u003cbr\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong style=\"font-size: 1.1em;\"\u003eThe Science of SIRT1 \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cbr\u003eInside every cell is a guardian protein called sirtuin 1 (SIRT1), short for Silent Information Regulator. It helps decide which parts of your DNA stay quiet and which stay active, helping cells adapt to stress, maintain energy efficiency, and resist the effects of aging.\u003cbr\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003eCommonly known as the \"longevity switch,\" SIRT1 is involved in DNA repair, the removal of damaged cellular components, and the optimization of energy use. As we age, SIRT1 activity naturally declines due to factors such as oxidative stress, poor diet, disrupted sleep, and environmental challenges. This reduction is linked to diminished cellular resilience and many of the classic signs of aging.\u003cbr\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003eThe good news is that certain food compounds can help support SIRT1 function. Plant-derived polyphenols such as resveratrol (from red grapes) and pterostilbene (from blueberries) are among the best-studied for their ability to activate SIRT1 and promote healthy cellular aging. These compounds mimic calorie restriction at the molecular level, helping to reactivate SIRT1 and restore youthful gene expression patterns. By boosting SIRT1 activity, they help shift cells into a protective, repair-focused state, supporting the body’s natural defenses as we age.*\u003csup\u003e1-7\u003cbr\u003e\u003cbr\u003e\u003c\/sup\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong style=\"font-size: 1.1em;\"\u003eWhy Resveratrol + Pterostilbene Work Better Togethe\u003cbr\u003e\u003cbr\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eResveratrol is well-known for supporting SIRT1, but the body clears it fast. The liver converts most of it into inactive metabolites within minutes. Blood levels fall quickly, so only a limited amount reaches cells. The effect on SIRT1 is meaningful, yet short-lived.*\u003csup\u003e1-3,5-7\u003cbr\u003e\u003cbr\u003e\u003c\/sup\u003e\u003c\/p\u003e\n\u003cp\u003ePterostilbene shifts the profile. It is a close relative of resveratrol with two methyl groups that improve its performance.\u003cbr\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eUp to 4× higher oral bioavailability*\u003c\/li\u003e\n\u003cli\u003eGreater lipophilicity for superior cellular penetration*\u003c\/li\u003e\n\u003cli\u003eSignificantly longer half-life in the body (up to 7× longer than resveratrol)*\u003csup\u003e4,14-16\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eWhen used together in a balanced ratio, the two ingredients work in sequence. Resveratrol supports a fast SIRT1 response. Pterostilbene keeps that response active for a longer period due to its greater stability. This provides steadier sirtuin pathway support than resveratrol alone.*\u003csup\u003e1-7,14-16\u003cbr\u003e\u003cbr\u003e\u003c\/sup\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong style=\"font-size: 1.1em;\"\u003eWhat Makes Ours Better?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003e4:1 Polyphenol Complex:\u003c\/strong\u003e Balanced to reflect bioavailability differences between resveratrol and pterostilbene.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eClinically Studied Forms:\u003c\/strong\u003e Includes the active trans form of resveratrol and pterostilbene for consistency and purity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLongevity Pathway Support:\u003c\/strong\u003e Engages SIRT1, AMPK and PGC-1α pathways linked to mitochondrial function and cellular upkeep.*\u003csup\u003e1-7\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMinimalist Formula:\u003c\/strong\u003e Uses only active polyphenols for a straightforward, clean profile.*\u003cbr\u003e\u003cbr\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong style=\"font-size: 1.1em;\"\u003eThe ProHealth Difference\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eDoctor-Formulated:\u003c\/strong\u003e Developed by our in-house science team in collaboration with leading wellness experts.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTriple Lab Tested:\u003c\/strong\u003e Verified three times by independent labs for purity and potency.\u003c\/li\u003e\n\u003cli\u003e \u003cstrong\u003eFull Transparency:\u003c\/strong\u003e Third-party test results published online for complete confidence.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eUSA Manufactured:\u003c\/strong\u003e Proudly manufactured in the USA in FDA-registered, GMP-certified facilities since 1988.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003e100-Day Risk-Free Guarantee:\u003c\/strong\u003e If you’re not fully satisfied, we’ll refund your purchase in full.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong style=\"font-size: 1.1em;\"\u003eA Word from our Chief Science Officer\u003cbr\u003e\u003cbr\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\"Resveratrol brought SIRT1 into the spotlight, but bioavailability has always limited its potential. By combining it with pterostilbene, we’re matching kinetics with biology — ensuring both rapid activation and sustained support of this key longevity pathway.\"\u003cbr\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong style=\"font-size: 1.1em;\"\u003eIngredient Info\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eTrans-Resveratrol:\u003c\/strong\u003e The active, naturally occurring form of resveratrol that supports key cellular pathways involved in healthy aging.*\u003cbr\u003e\u003cstrong\u003eTrans-Pterostilbene:\u003c\/strong\u003e A lipophilic stilbene that engages the SIRT1 pathway and complements resveratrol for steady cellular support.*\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eReferences:\u003c\/strong\u003e\u003c\/p\u003e\n\u003col\u003e\n\u003cli\u003eDella Vedova L et al. \u003cem\u003ePharmaceuticals (Basel)\u003c\/em\u003e. 2025;18(2):138.\u003c\/li\u003e\n\u003cli\u003eZhou DD et al. \u003cem\u003eSubcell Biochem\u003c\/em\u003e. 2024;107:183-203.\u003c\/li\u003e\n\u003cli\u003eLi YR et al. \u003cem\u003eBiofactors\u003c\/em\u003e. 2018;44(1):69-82.\u003c\/li\u003e\n\u003cli\u003eWood JG et al. \u003cem\u003eNature\u003c\/em\u003e. 2004;430(7000):686-689.\u003c\/li\u003e\n\u003cli\u003eKuršvietienė L et al. \u003cem\u003eMedicina\u003c\/em\u003e. 2016;52(3),148-155.\u003c\/li\u003e\n\u003cli\u003eLakshminarasimhan M et al. \u003cem\u003eAging (Albany NY)\u003c\/em\u003e. 2013;5(3),151.\u003c\/li\u003e\n\u003cli\u003eBorra MT et al. \u003cem\u003eJ Biol Chem\u003c\/em\u003e. 2005;280(17),17187-17195.\u003c\/li\u003e\n\u003cli\u003eThaung Zaw JJ et al. \u003cem\u003eClin Nutr\u003c\/em\u003e. 2021;40(3):820-829.\u003c\/li\u003e\n\u003cli\u003eThaung Zaw JJ et al. \u003cem\u003eMenopause.\u003c\/em\u003e 2021;28(1):40-49.\u003c\/li\u003e\n\u003cli\u003eWong RH et al. \u003cem\u003eJ Bone Miner Res\u003c\/em\u003e. 2020;35(11):2121-2131.\u003c\/li\u003e\n\u003cli\u003eThaung Zaw JJ et al. \u003cem\u003eNutrients\u003c\/em\u003e. 2020;12(3):828.\u003c\/li\u003e\n\u003cli\u003eChan EWC et al. \u003cem\u003eJ Appl Pharm Sci.\u003c\/em\u003e 2019;9(7):124-129.\u003c\/li\u003e\n\u003cli\u003eDella Vedova L et a. \u003cem\u003ePharmaceuticals (Basel)\u003c\/em\u003e. 2025;18(2):138.\u003c\/li\u003e\n\u003cli\u003eWang P, Sang S. \u003cem\u003eBiofactors.\u003c\/em\u003e 2018;44(1):16-25.\u003c\/li\u003e\n\u003cli\u003eRiche DM et al.  \u003cem\u003eJ Toxicol\u003c\/em\u003e. 2013;2013:463595.\u003c\/li\u003e\n\u003cli\u003eKapetanovic IM et al. \u003cem\u003eCancer Chemother Pharmacol.\u003c\/em\u003e 2011;68(3):593-601.\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"product-label-copy\"\u003e\n\u003ctable border=\"0\" cellpadding=\"0\" cellspacing=\"2\" width=\"100%\" style=\"height: 275.333px;\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 20.5333px;\"\u003e\n\u003cth align=\"left\" style=\"font-size: 11pt; font-weight: bold; height: 20.5333px;\" colspan=\"3\"\u003eSupplement Facts\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.6px;\"\u003e\n\u003ctd class=\"smalltext\" colspan=\"3\" style=\"height: 19.6px;\"\u003eServing Size: 1 Capsule\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.6px;\"\u003e\n\u003ctd class=\"smalltext\" colspan=\"3\" style=\"height: 19.6px;\"\u003eServings Per Container: 60\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.6px;\"\u003e\n\u003ctd style=\"font-weight: bold; height: 19.6px;\" class=\"smalltext\" colspan=\"2\"\u003eAmount Per Serving\u003c\/td\u003e\n\u003ctd align=\"right\" class=\"smalltext\" style=\"white-space: nowrap; height: 19.6px;\"\u003e\u003cstrong\u003e%DV\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.6px;\"\u003e\n\u003ctd class=\"smalltext\" style=\"height: 19.6px;\"\u003eVeri-te® Trans-Resveratrol\u003c\/td\u003e\n\u003ctd align=\"right\" style=\"white-space: nowrap; height: 19.6px;\" class=\"smalltext\"\u003e200 mg\u003c\/td\u003e\n\u003ctd align=\"right\" style=\"white-space: nowrap; height: 19.6px;\" class=\"smalltext\"\u003e†\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.6px;\"\u003e\n\u003ctd class=\"smalltext\" style=\"height: 19.6px;\"\u003eTrans-Pterostilbene\u003c\/td\u003e\n\u003ctd align=\"right\" style=\"white-space: nowrap; height: 19.6px;\" class=\"smalltext\"\u003e50 mg\u003c\/td\u003e\n\u003ctd align=\"right\" style=\"white-space: nowrap; height: 19.6px;\" class=\"smalltext\"\u003e†\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 39.2px;\"\u003e\n\u003ctd class=\"smalltext\" colspan=\"3\" style=\"height: 39.2px;\"\u003e† Percent Daily Values (DV) not established\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cbr\u003e\n\u003cp\u003eREV.10.25\u003c\/p\u003e\nVeri-te® is a registered trademark of the Lallemand group.\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eOTHER INGREDIENTS: \u003c\/strong\u003eRice flour, hypromellose (capsule).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSUGGESTED DAILY USE: \u003c\/strong\u003eTake one (1) capsule per day with food.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAUTION: \u003c\/strong\u003eFor use by healthy adults only. Please consult your physician before use if you are pregnant or nursing, under the age of 18, or are undergoing treatment for a medical condition. Do not exceed the suggested use. \u003cstrong\u003eKEEP OUT OF REACH OF CHILDREN\u003c\/strong\u003e. Store in a cool and dry place after opening.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e","brand":"ProHealth Wholesale","offers":[{"title":"Default Title","offer_id":53047126982816,"sku":"PH665","price":39.95,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0507\/7588\/3936\/files\/PH665_175CC_FRNT_600x600-REV-1025.png?v=1763681455"}],"url":"https:\/\/wholesale.prohealth.com\/collections\/sirtuin-activation.oembed","provider":"ProHealth Wholesale","version":"1.0","type":"link"}