{"title":"Pterostilbene","description":"","products":[{"product_id":"prohealth-pterostilbene-pro-250-250-mg-60-capsules-ph577","title":"Pterostilbene Pro 250 - 250 mg, 60 capsules","description":"\u003cdiv class=\"product-benefits-copy\"\u003e\n\u003ch2\u003ePterostilbene is a powerful antioxidant that is similar to, but more bioavailable than resveratrol. Pterostilbene promotes longevity and improves markers associated with heart and brain health.\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eSupports cardiovascular health* \u003c\/li\u003e\n\u003cli\u003ePromotes brain cell health* \u003c\/li\u003e\n\u003cli\u003eActivates sirtuins to support healthy aging \u003c\/li\u003e\n\u003cli\u003eBoosts effectiveness of NMN \u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cspan style=\"color: #0000ff;\"\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0507\/7588\/3936\/files\/PH577_-_COA_Brighton_LOT_23338b_2025-07-17.pdf?v=1753713883\" rel=\"noopener noreferrer\" style=\"color: #0000ff;\" target=\"_blank\"\u003eView Certificate of Analysis \u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003ch3\u003eResearch-Supported Benefits:\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eSupports Longevity.\u003c\/strong\u003e Pterostilbene activates “longevity genes” known as sirtuins. Research shows that activating sirtuins promotes cellular health and extends lifespan of animals. \u003csup\u003e1 2\u003c\/sup\u003e Activating sirtuins aids in DNA repair, promoting cellular stress resistance, regulating autophagy (cellular detoxification) and inflammation. \u003csup\u003e3\u003cbr\u003e\u003cbr\u003e\u003c\/sup\u003e\u003cstrong\u003ePromotes Heart Health.\u003c\/strong\u003e Research shows that pterostilbene promotes heart health in a variety of ways, one of which is reducing oxidative stress of the heart. \u003csup\u003e4\u003c\/sup\u003e Oxidative stress contributes to inflammation and accelerated aging of heart cells. Reducing levels of oxidative stress reduces risk of age-related decline of heart health.\u003cbr\u003e\u003cbr\u003e\u003cstrong\u003eProtects the Aging Brain.\u003c\/strong\u003e Pterostilbene has been shown to reduce neuroinflammation (inflammation of brain cells), reducing oxidative-stress-related damage to brain cells 5. Research shows that neuroinflammation contributes to age-related brain decline symptoms such related to memory and information processing.\u003csup\u003e6\u003cbr\u003e\u003cbr\u003e\u003c\/sup\u003e\u003cstrong\u003eReferences:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e1. Cheng Y, Di S, Fan C, et al. SIRT1 activation by pterostilbene attenuates the skeletal muscle oxidative stress injury and mitochondrial dysfunction induced by ischemia reperfusion injury. Apoptosis. 2016;21(8):905-916. doi:10.1007\/s10495-016-1258-x \u003cbr\u003e\u003cbr\u003e2. Lee SH, Lee JH, Lee HY, Min KJ. Sirtuin signaling in cellular senescence and aging. BMB Rep. 2019;52(1):24-34. doi:10.5483\/BMBRep.2019.52.1.290 doi:10.5483\/BMBRep.2019.52.1.290 \u003cbr\u003e\u003cbr\u003e3. Vazquez BN, Thackray JK, Serrano L. Sirtuins and DNA damage repair: SIRT7 comes to play. Nucleus. 2017;8(2):107-115. doi:10.1080\/19491034.2016.1264552\u003cbr\u003e\u003cbr\u003e4. Kosuru R, Kandula V, Rai U, Prakash S, Xia Z, Singh S. Pterostilbene Decreases Cardiac Oxidative Stress and Inflammation via Activation of AMPK\/Nrf2\/HO-1 Pathway in Fructose-Fed Diabetic Rats. Cardiovasc Drugs Ther. 2018;32(2):147-163. doi:10.1007\/s10557-018-6780-3\u003cbr\u003e\u003cbr\u003e5. Park B, Lee YJ. Pterostilbene Improves Stress-Related Behaviors and Partially Reverses Underlying Neuroinflammatory and Hormonal Changes in Stress-Challenged Mice. J Med Food. 2021;24(3):299-309. doi:10.1089\/jmf.2020.4766\u003cbr\u003e\u003cbr\u003e6. Ahmad MA, Kareem O, Khushtar M, et al. Neuroinflammation: A Potential Risk for Dementia. Int J Mol Sci. 2022;23(2):616. Published 2022 Jan 6. doi:10.3390\/ijms23020616\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"product-how-it-work-copy\"\u003e\n\u003cul\u003e\n\u003cli\u003ePterostilbene has been shown to activate longevity genes known as sirtuins, which play a critical role in regulating cellular aging. \u003c\/li\u003e\n\u003cli\u003eSirtuins require NAD+ for fuel, making pterostilbene and NMN a perfect supplement combination to promote longevity. \u003c\/li\u003e\n\u003cli\u003eBy activating sirtuins, pterostilbene supports DNA stability and promotes DNA repair. \u003c\/li\u003e\n\u003cli\u003ePterostilbene’s antioxidant effects promote heart and brain health by reducing oxidative stress and inflammation. \u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\u003cdiv class=\"product-label-copy\"\u003e\n\u003ctable border=\"0\" cellpadding=\"0\" cellspacing=\"2\" width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003cth align=\"left\" colspan=\"3\" style=\"font-size: 11pt; font-weight: bold;\"\u003eSupplement Facts\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd colspan=\"3\" class=\"smalltext\"\u003eServing Size: 1 Capsule\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd colspan=\"3\" class=\"smalltext\"\u003eServings Per Container: 60\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd colspan=\"2\" class=\"smalltext\" style=\"font-weight: bold;\"\u003eAmount Per Serving\u003c\/td\u003e\n\u003ctd align=\"right\" style=\"white-space: nowrap;\" class=\"smalltext\"\u003e\u003cstrong\u003e%DV\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"smalltext\"\u003ePterostilbene\u003c\/td\u003e\n\u003ctd align=\"right\" class=\"smalltext\" style=\"white-space: nowrap;\"\u003e250 mg\u003c\/td\u003e\n\u003ctd align=\"right\" class=\"smalltext\" style=\"white-space: nowrap;\"\u003e†\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd colspan=\"3\" class=\"smalltext\"\u003e† Daily Value (DV) not established.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\nREV.08.25 \u003cbr\u003e\u003cbr\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eOTHER INGREDIENTS: \u003c\/strong\u003eHypromellose (capsule), rice flour.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSUGGESTED DAILY USE: \u003c\/strong\u003eTake one (1) capsule 1-2 times per day, preferably with food.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAUTION: \u003c\/strong\u003eFor use by healthy adults only. Please consult your physician before use if you are pregnant or nursing, under the age of 18, or are undergoing treatment for a medical condition. Do not exceed the suggested use. \u003cstrong\u003eKEEP OUT OF REACH OF  CHILDREN\u003c\/strong\u003e. Store in a cool and dry place aer opening.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"summary-copy\"\u003e\n\u003cp\u003e\u003cstrong\u003eClinical-Supported Dosing.\u003c\/strong\u003e ProHealth Longevity’s Pterostilbene Pro 250 contains 250 mg of pterostilbene per serving, a clinically effective dose to promote longevity.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eQuality Manufacturing Practices.\u003c\/strong\u003e All of our products are manufactured in an FDA-registered, GMP-certified facility.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eThird-Party Tested in the USA.\u003c\/strong\u003e Every batch is third-party tested in US laboratories to ensure the highest quality, purity and potency. Certificates of Analysis are available.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"ProHealth Wholesale","offers":[{"title":"Default Title","offer_id":45096795078816,"sku":"PH577","price":29.15,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0507\/7588\/3936\/files\/PH577_175ML_FRNT_600x600_REV0825-2.png?v=1780603447"},{"product_id":"prohealth-nicotinamide-riboside-pterostilbene-30-capsules-ph710","title":"Nicotinamide Riboside + Pterostilbene - 30 capsules","description":"\u003cdiv class=\"product-benefits-copy\"\u003e\n\u003cp\u003eNicotinamide riboside (NR), an advanced form of vitamin B3 (niacin), has proven to be one of the most promising supplements to promote longevity and healthy aging. By functioning as an NAD+ precursor, NR has been proven to significantly increase NAD+ levels in the body, thus promoting heart, brain, metabolic, and cellular health. Pterostilbene is a powerful antioxidant compound that has been shown to activate sirtuins (longevity genes), amplifying the longevity-promoting effects of NR.\u003c\/p\u003e\n\u003ch2\u003eNR + Pterostilbene\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eSupports longevity by increasing NAD+ levels and activating sirtuins\u003c\/li\u003e\n\u003cli\u003eEnhances cellular health by promoting DNA repair and reducing oxidative stress\u003c\/li\u003e\n\u003cli\u003ePromotes heart health by supporting healthy blood flow\u003c\/li\u003e\n\u003cli\u003eProtects the brain from age-related functional decline\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cspan style=\"color: #0000ff;\"\u003e\u003ca style=\"color: #0000ff;\" href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0507\/7588\/3936\/files\/PH710_-_COA_Brighton_LOT_26033_2025.09.10_2.pdf?v=1757958063\" target=\"_blank\"\u003eView Certificate of Analysis »\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003ch3\u003eResearch-Supported Benefits:\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003ePromotes Longevity. \u003c\/strong\u003eNicotinamide Riboside promotes longevity by increasing levels of NAD+ in the body. NAD+ levels decline with age, contributing to accelerated cellular aging and health decline. Research shows that increasing NAD+ levels in aged animals extends lifespan. (1) Pterostilbene supports longevity by activating sirtuins, which are commonly referred to as \"longevity genes\". Animal studies show that activating sirtuins extends lifespan and healthspan. (2)\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSupports Cellular Health.\u003c\/strong\u003e By increasing NAD+ levels, NR aids in facilitating DNA repair. (3) DNA damage is associated with decreased longevity and increased risk for age-related health decline, highlighting the importance of the DNA repair process. Due to its antioxidant potential, pterostilbene offers additional protection for cellular health by reducing oxidative damage, a key contributor to cellular aging. (4)\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eEnhances Heart Health. \u003c\/strong\u003eResearch shows that NR enhances heart health by reducing stiffness of the arteries and supporting healthy blood flow. (5) Aortic stiffness contributes to blood pressure dysregulation and increased cardiac risk, making the reduction of aortic stiffness critical to maintaining heart health. Animal studies also show pterostilbene exhibits cardio-protective effects by reducing oxidative stress of heart tissue. (6)\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eProtects Against Cognitive Decline. \u003c\/strong\u003eNAD+ is critical to maintaining mitochondrial health of brain cells. A decline of NAD+ levels research suggests that reduced NAD+ levels contribute to many of the hallmarks of brain aging. By increasing NAD+ levels and aiding in the regulation of inflammatory levels, Nicotinamide Riboside shows promise in supporting healthy brain aging and cognitive function. (7) Pterostilbene further supports healthy brain aging by activating sirt-1 and improving synaptic plasticity, a vital biological process related to memory and learning. (8)\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eReferences:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e1. Fang EF, Lautrup S, Hou Y, et al. NAD+ in Aging: Molecular Mechanisms and Translational Implications. Trends Mol Med. 2017;23(10):899-916. doi:10.1016\/j.molmed.2017.08.001 \u003cbr\u003e\u003cbr\u003e2. Grabowska W, Sikora E, Bielak-Zmijewska A. Sirtuins, a promising target in slowing down the ageing process. Biogerontology. 2017;18(4):447-476. doi:10.1007\/s10522-017-9685-9 \u003cbr\u003e\u003cbr\u003e3. Wilk A, Hayat F, Cunningham R, et al. Extracellular NAD+ enhances PARP-dependent DNA repair capacity independently of CD73 activity. Sci Rep. 2020;10(1):651. Published 2020 Jan 20. doi:10.1038\/s41598-020-57506-9 \u003cbr\u003e\u003cbr\u003e4. Nagarajan S, Mohandas S, Ganesan K, Xu B, Ramkumar KM. New Insights into Dietary Pterostilbene: Sources, Metabolism, and Health Promotion Effects. Molecules. 2022;27(19):6316. Published 2022 Sep 25. doi:10.3390\/molecules27196316 \u003cbr\u003e\u003cbr\u003e5. Martens CR, Denman BA, Mazzo MR, et al. Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults. Nat Commun. 2018;9(1):1286. Published 2018 Mar 29. doi:10.1038\/s41467-018-03421-7 \u003cbr\u003e\u003cbr\u003e6. Kosuru R, Kandula V, Rai U, Prakash S, Xia Z, Singh S. Pterostilbene Decreases Cardiac Oxidative Stress and Inflammation via Activation of AMPK\/Nrf2\/HO-1 Pathway in Fructose-Fed Diabetic Rats. Cardiovasc Drugs Ther. 2018;32(2):147-163. doi:10.1007\/s10557-018-6780-3 \u003cbr\u003e\u003cbr\u003e7. Lee HJ, Yang SJ. Supplementation with Nicotinamide Riboside Reduces Brain Inflammation and Improves Cognitive Function in Diabetic Mice. Int J Mol Sci. 2019;20(17):4196. Published 2019 Aug 27. doi:10.3390\/ijms20174196 \u003cbr\u003e\u003cbr\u003e8. Michán S, Li Y, Chou MM, et al. SIRT1 is essential for normal cognitive function and synaptic plasticity. J Neurosci. 2010;30(29):9695-9707. doi:10.1523\/JNEUROSCI.0027-10.2010 \u003cbr\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"product-how-it-work-copy\"\u003e\n\u003cul\u003e\n\u003cli\u003eNicotinamide Riboside (NR) and pterostilbene represent a powerful 1-2 combo in longevity supplements due to their respective ability to increase NAD+ levels and activate sirtuins.\u003c\/li\u003e\n\u003cli\u003eNAD+ functions as the fuel for sirtuins, which then activate defensive enzymes to fight aging.\u003c\/li\u003e\n\u003cli\u003eNAD+ levels decline with age, with an estimated 50% decline in NAD+ levels by age 50\u003c\/li\u003e\n\u003cli\u003eThis decline in NAD+ production reduces the ability of sirtuins to perform their anti-aging repair effects.\u003c\/li\u003e\n\u003cli\u003eNR and pterostilbene further support healthy aging by improving mitochondrial health, supporting cardiovascular function, and protecting against symptoms of brain aging.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"product-label-copy\"\u003e\n\u003ctable width=\"100%\" cellspacing=\"2\" cellpadding=\"0\" border=\"0\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003cth colspan=\"3\" style=\"font-size: 11pt; font-weight: bold;\" align=\"left\"\u003eSupplement Facts\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd colspan=\"3\" class=\"smalltext\"\u003eServing Size: 1 Capsule\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd colspan=\"3\" class=\"smalltext\"\u003eServings Per Container: 30\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd colspan=\"2\" class=\"smalltext\" style=\"font-weight: bold;\"\u003eAmount Per Serving\u003c\/td\u003e\n\u003ctd style=\"white-space: nowrap;\" class=\"smalltext\" align=\"right\"\u003e\u003cstrong\u003e%DV\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"smalltext\"\u003eNR (as Nicotinamide Riboside \u003cbr\u003e  Hydrogen Malate)\u003c\/td\u003e\n\u003ctd class=\"smalltext\" style=\"white-space: nowrap;\" align=\"right\"\u003e250 mg\u003c\/td\u003e\n\u003ctd class=\"smalltext\" style=\"white-space: nowrap;\" align=\"right\"\u003e†\u003cbr\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"smalltext\"\u003ePterostilbene\u003c\/td\u003e\n\u003ctd class=\"smalltext\" style=\"white-space: nowrap;\" align=\"right\"\u003e40 mg\u003cbr\u003e\n\u003c\/td\u003e\n\u003ctd class=\"smalltext\" style=\"white-space: nowrap;\" align=\"right\"\u003e†\u003cbr\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd colspan=\"3\" class=\"smalltext\"\u003e† Daily Value (DV) not established\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\nREV.07.25\u003cbr\u003e\u003cbr\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eOTHER INGREDIENTS: \u003c\/strong\u003eHypromellose (capsule), rice flour.\u003cstrong\u003e \u003c\/strong\u003e\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSUGGESTED DAILY USE:\u003c\/strong\u003e Take one (1) capsule per day, with or without food, preferably in the morning.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAUTION:\u003c\/strong\u003e For use by healthy adults only. Please consult your physician before use if you are pregnant or nursing, under the age of 18, or are undergoing treatment for a medical condition. Do not exceed the suggested use. \u003cstrong\u003eKEEP OUT OF REACH OF CHILDREN\u003c\/strong\u003e. Store in a cool and dry place after opening.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"summary-copy\"\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eUnique Formulation. \u003c\/strong\u003eProHealth’s NR + Pterostilbene was specifically formulated to reduce symptoms of age-related health decline. By combining these two complimentary ingredients, this formula amplifies the effect of either ingredient if taken alone.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eQuality Manufacturing Practices.\u003c\/strong\u003e All of our products are manufactured in an FDA-registered, GMP-certified facility.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eThird-Party Tested in the USA.\u003c\/strong\u003e Every batch is third-party tested in US laboratories to ensure the highest quality, purity and potency. Certificates of Analysis are available.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e","brand":"ProHealth Wholesale","offers":[{"title":"Default Title","offer_id":52366405468320,"sku":"PH710","price":29.95,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0507\/7588\/3936\/files\/PH710_175MCC_FRNT_600x600_REV1124.png?v=1744215932"}],"url":"https:\/\/wholesale.prohealth.com\/collections\/pterostilbene.oembed","provider":"ProHealth Wholesale","version":"1.0","type":"link"}